Percutaneous Absorption and Principles of Corneotherapy/Skin Care
Those substances with a molecular weight larger than 500 Da can hardly penetrate through the skin covered by just a 10- mm thick SC as skin barrier.
The SC barrier function depends on the presence of its unique intercellular lipids that are tightly bound to maturated corneocytes, whose formation is disturbed in diseased skin.
The SC barrier function is not uniform and greatly differs among various body locations with extremely poor barrier function in the face and genital skin.
The bypass pathway penetration through hair follicles and sweat ducts may allow quick but only small amount of penetration of externally applied substances.
Excessive SC hydration induced by occlusion causes swelling of the corneocytes to lead to several to more than tenfold increase in percutaneous absorption of applied drugs.
Normal SC binds water to keep the skin surface smooth and soft in contrast to pathologic SC with deficient water-binding capacity that produces a scaly or cracked skin surface.
Corneotherapy consisting of daily applications of a highly moisturizing agent not only induces long-lasting increase in skin surface hydration but also repairs mild SC barrier dysfunction such as noted in atopic xerosis.
KeywordsAtopic Dermatitis Stratum Corneum Allergic Contact Dermatitis Atopic Dermatitis Patient Percutaneous Absorption
Transepidermal water loss.
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