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Abbreviations
- APC:
-
Antigen presenting cells.
- CHS:
-
Contact hypersensitivity.
- IL:
-
Interleukin.
- LC:
-
Langerhans cells.
- TLR:
-
Toll-like recpetors.
- TNF:
-
Tumor necrosis factor.
References
Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675–680
Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252
Bennett CL, van Rijn E, Jung S, Inaba K, Steinman RM, Kapsenberg ML, Clausen BE (2005) Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569–576
Delves PJ, Roitt IM (2000) The immune system. First of two parts. N Engl J Med 343:37–49
Gläser R, Harder J, Lange H, Bartels J, Christophers E, Schröder JM (2005) Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol 6:57–64
Grabbe S, Schwarz T (1998) Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensi-tivity. Immunol Today 19:37–44
Grabbe S, Steinert M, Mahnke K et al (1996) Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 98:1158–1164
Guermonprez P, Amigorena S (2005) Pathways for antigen cross presentation. Springer Semin Immunopathol 26:257–271
Harder J, Schröder JM (2005) Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol 77:476–486
Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ (2005) Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23:611–620
Kissenpfennig A, Henri S, Dubois B, Laplace-Builhé C, Perrin P, Romani N, Tripp CH, Douillard P, Leserman L, Kaiserlian D, Saeland S, Davoust J, Malissen B (2005) Dynamics and function of langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643–654
Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S (2006) Epidermal RANKL control regulatory T cell numbers via dendritic cells. Nat. Med 12:1372–1379
Medzhitov R, Janeway C Jr (2000) Innate immunity. N Engl J Med 343:338–344
Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG (2002) Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3:1135–1141
Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151–1160
Parkin J, Cohen B (2001) An overview of the immune system. Lancet 357:1777–1789
Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF (2005) Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309:1380–1384
Robert C, Kupper TS (1999) Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 341:1817–1828
Steinbrink K, Sorg C, Macher E (1996) Low zone tolerance to contact allergens in mice: a functional role for CD8+ T helper type 2 cells. J Exp Med 183:759–768
Stingl G, Maurer D, Hauser C, Wolff K (1999) The epidermis: an immunologic microenvironment. In: Freedberg IM, Eisen AZ, Wolff K et al (eds) Fitzpatrick's dermatology in general medicine vol 1. McGraw-Hill, New York, pp 343–370
Stingl G, Maurer D (1997) IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells. Int Arch Allergy Immunol 113:24–29
Streilein JW (1983) Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol 80 (Suppl):12s–16s
Toews GB, Bergstresser PR, Streilein JW (1980) Epidermal Langerhans cell density determines whether contact hyper-sensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445–453
Valladeau J, Ravel O, Dezutter-Dambuyant C et al (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12:71–81
Wang B, Rieger A, Kilgus O et al (1992) Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI. J Exp Med 175:1353–1365
Watts C (1997) Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol 15:821–850
Watts C (2001) Antigen processing in the endocytic compartment. Curr Opin Immunol 13:26–31
Acknowledgments
Many important aspects and references could not be included due to space restrictions. We apologize to the respective authors. This work was supported by the Deutsche Forschungsgemeinschaft (DFG, SFB 617/A21; SCHW1177/1-1/1-2; SFB 293/B8; BE1580/7-1), Interdisciplinary Clinical Research Center (IZKF) Münster, and the Medical Faculty (IMF), University of Münster, Germany
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Schwarz, T., Beissert, S. (2010). Immune Mechanisms. In: Krieg, T., Bickers, D.R., Miyachi, Y. (eds) Therapy of Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78814-0_2
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