Inference on Missing Values in Genetic Networks Using High-Throughput Data

  • Zdena Koukolíková-Nicola
  • Pietro Liò
  • Franco Bagnoli
Conference paper

DOI: 10.1007/978-3-540-78757-0_10

Part of the Lecture Notes in Computer Science book series (LNCS, volume 4973)
Cite this paper as:
Koukolíková-Nicola Z., Liò P., Bagnoli F. (2008) Inference on Missing Values in Genetic Networks Using High-Throughput Data. In: Marchiori E., Moore J.H. (eds) Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. EvoBIO 2008. Lecture Notes in Computer Science, vol 4973. Springer, Berlin, Heidelberg


High-throughput techniques investigating for example protein-protein or protein-ligand interactions produce vast quantity of data, which can conveniently be represented in form of matrices and can as a whole be regarded as knowledge networks. Such large networks can inherently contain more information on the system under study than is explicit from the data itself. Two different algorithms have previously been developed for economical and social problems to extract such hidden information. Based on three different examples from the field of proteomics and genetic networks, we demonstrate the great potential of applying these algorithms to a variety of biological problems.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Zdena Koukolíková-Nicola
    • 1
  • Pietro Liò
    • 2
  • Franco Bagnoli
    • 3
  1. 1.Fachhochschule NordwestschweizHochschule für TechnikWindischSwitzerland
  2. 2.The Computer LaboratoryUniversity of CambridgeCambridgeUK
  3. 3.Department of Energy, University of Florence, Via S. Marta, 3 50139 Firenze. Also CSDC and INFN, sez. Firenze 

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