Abstract
In 1925, Herrmann Blumgart used radioactive indicators in human beings for evaluation of cardiac function. Prinzmetal and colleagues were the first to publish firstpass radionuclide angiography (RNA) results in normal subjects and those with valvular and congenital heart disease, using intravenous injection of Na-24 [1]. With the advent of computers in the 1970s, images were evaluated quantitatively and compared for dynamic changes that occur within a cardiac cycle. In 1971, Strauss and colleagues introduced the concept of using electrocardiography (ECG) to trigger image frame acquisition [2].
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References
Corday PE, Bergman HC, Schwartz L, Spritzler RJ (1948) Radiocardiography a new method for studying the blood flow through the chambers of the heart in human beings. Science 108:340–341.
Strauss HW, Zaret BL, Hurley PJ, Natarajan TK, Pitt B (1971) A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization, Am J Cardiol 28:575–580.
Secker-Walker RH, Resnick L, Kunz H, Parker JA, Hill RL, Potchen EJ (1973) Measurement of left ventricular ejection fraction. J Nucl Med. 4:798–802.
Nishimura T, Hamada S, Hayashida K, Uehara T, Katabuchi T, Hayashi M (1989) Cardiac blood-pool scintigraphy using technetium-99m DTPA-HSA: comparison with in vivo technetium-99m RBC labeling. J Nucl Med 30:1713–1717.
Pavel DG, Zimmer M, Patterson VN (1977) In vivo labeling of red blood cells with 99mTc: a new approach to blood pool visualization. J Nucl Med 18:305–308.
Hamilton RG, Alderson PO (1977) A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with [99mTc] pertechnetate. J Nucl Med 18:1010–1013.
Callahan RJ, Froelich JW, McKusick KA, Leppo J, Strauss HW (1982) A modified method for the in vivo labeling of red blood cells with Tc-99m: concise communication. J Nucl Med 23:315–318.
Hegge FN, Hamilton GW, Larson SM, Ritchie JL, Richards P (1978) Cardiac chamber imaging: a comparison of red blood cells labeled with Tc-99m in vitro and in vivo. J Nucl Med 19:129–134.
Tamaki N, Mukai T, Ishii Y et al. (1983) Multiaxial tomography of heart chambers by gated blood-pool emission computed tomography using a rotating gamma camera. Radiology 147:547–554.
Barat JL, Brendel AJ, Colle JP et al. (1984) Quantitative analysis of left-ventricular function using gated single photon emission tomography, J Nucl Med 25:1167–1174.
Corbett JR, Jansen DE, Lewis SE et al. (1985) Tomographic gated blood pool radionuclide ventriculography analysis of wall motion and left ventricular volumes in patients with coronary artery disease, J Am Coll Cardiol 6:349–358.
Casset-Senon D, Babuty D, Alison D et al. (2000) Delayed contraction area responsible for sustained ventricular tachycardia in an arrhythmogenic right ventricular cardiomyopathy demonstration by Fourier analysis of SPECT equilibrium radionuclide angiography. J Nucl Cardiol 7:539–542.
Henkin RE (1984) Interventional equilibrium in blood pool studies. Crit Rev Diagn Imaging. 20:261–282.
Winzelberg GG, Boucher CA et al. (1981) Right ventricular function in aortic and mitral valve disease. Chest 79:520–528.
Sandler H, Dodge HT (1968) The use of single plane angiocardiograms for the calculation of left ventricular volume in man. Am Heart J 75:325–334.
Levy WC, Cerqueira MD, Matsuoka DT, Harp GD, Sheehan FH, Stratton JR (1992) Four radionuclide methods for left ventricular volume determination: comparison of a manual and an automated technique. J Nucl Med 33:763–770.
Williams KA (2005) A historical perspective on measurement of ventricular function with scintigraphic techniques: Part II – Ventricular function with gated techniques for blood pool and perfusion imaging. J Nucl Cardiol 22:208–215.
Agarwala S, Kumar R, Bhatnagar V, Bajpai M, Gupta DK, Mitra DK (2000) High incidence of adriamycin cardiotoxicity in children even at low cumulative doses: role of radionuclide cardiac angiography. J Pediatr Surg 35:1786–1789.
Palmeri ST, Bonow RO, Myers CE et al. (1986) Prospective evaluation of doxorubicin cardiotoxicity by rest and exercise radionuclide angiography. Am J Cardiol 58:607–613.
Schwartz RG, McKenzie WB, Alexander J et al. (1987) Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy. Seven-year experience using serial radionuclide angiocardiography. Am J Med 82:1109–1118.
Isner JM, Roberts WC (1978) Right ventricular infarction complicating left ventricular infarction secondary to coronary heart disease. Frequency, location, associated findings and significance from analysis of 236 necropsy patients with acute or healed myocardial infarction. Am J Cardiol 42:885–894.
Meizlish JL, Berger HJ, Plankey M, Errico D, Levy W, Zaret BL (1984) Functional left ventricular aneurysm formation after acute anterior transmural myocardial infarction: incidence, natural history, and prognostic implications. N Engl J Med 311:1001–1006.
The Multicenter Postinfarction Research Group (1983) Risk stratification and survival after myocardial infarction. N Engl J Med 309:331–336.
Ahnve S, Gilpin E, Henning H, Curtis G, Collins D, Ross J Jr (1986) Limitations and advantages of the ejection fraction for defining high risk after acute myocardial infarction. Am J Cardiol 58:872–878.
de Chillou C, Sadoul N, Bizeau O et al. (1997) Prognostic value of thrombolysis, coronary artery patency, signal-averaged electrocardiography, left ventricular ejection fraction, and Holter electrocardiographic monitoring for life-threatening ventricular arrhythmias after a first acute myocardial infarction. Am J Cardiol 80:852–858.
Harris PJ, Harrell FE Jr, Lee KL, Rosati RA (1980) Nonfatal myocardial infarction in medically treated patients with coronary artery disease. Am J Cardiol 46:937–942.
Coronary Artery Surgery Study (CASS): a randomized trial of coronary bypass surgery: survival data (1983) Circulation 68:939–950.
Ritchie JL, Hallstrom AP, Troubaugh GB, Caldwell JH, Cobb LA (1985) Out-of-hospital sudden coronary death: rest and exercise radionuclide left ventricular function in survivors. Am J Cardiol 55:645–651.
Lee KL, Pryor DB, Pieper KS et al. (1990) Prognostic value of radionuclide angiography in medically treated patients with coronary artery disease. A comparison with clinical and catheterization variables. Circulation 82:1705–1717.
Shaw LJ, Heinle SK, Borges-Neto S, Kesler K, Coleman RE, Jones RH (1998) Prognosis by measurements of left ventricular function during exercise. Duke Noninvasive Research Working Group. J Nucl Med 39:140–146.
Taliercio CP, Clements IP, Zinsmeister AR, Gibbons RJ (1988) Prognostic value and limitations of exercise radionuclide angiography in medically treated coronary artery disease. Mayo Clin Proc 63:573–582.
Jones RH, Floyd RD, Austin EH et al. (1983) The role of radionuclide angiocardiography in the preoperative prediction of pain relief and prolonged survival following coronary artery bypass grafting. Ann Surg 197:743–754.
Mast ST, Shaw LK, Ravizzini GC et al. (2001) Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variables. J Nucl Med 42:871–877.
Takeuchi M, Fujitani K, Kurogane K et al. (1985) Effects of diltiazem and nitroglycerin on left ventricular diastolic properties in patients with coronary artery disease. Jpn Heart J 26:509–520.
Barilla F, Gheorghiade M, Alam M, Khaja F, Goldstein S (1991) Low-dose dobutamine in patients with acute myocardial infarction identifies viable but not contractile myocardium and predicts the magnitude of improvement in wall motion abnormalities in response to coronary revascularisation. Am Heart J 122:1522–1531.
Bonow RO, Dilsizian V, Cuocolo A, Bacharach SL (1991) Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction: comparison of thallium scintigraphy with reinjection and PET imaging with 18F-Fluorodeoxyglucose. Circulation 83:26–37.
Firth BG, Dehmer GJ, Markham RV, Willerson JT, Hillis LD (1982) Assessment of vasodilator therapy in patients with severe congestive heart failure: limitations of measurements of left ventricular ejection fraction and volumes. Am J Cardiol 50:954–959.
Soufer R, Wohlgelernter D, Vita NA et al. (1985) Intact systolic left ventricular function in clinical congestive heart failure. Am J Cardiol 55:1032–1036.
Bonow RO, Vitale DF, Maron BJ, Bacharach SL, Frederick TM, Green MV (1987) Regional left ventricular asynchrony and impaired global left ventricular filling in hypertrophic cardiomyopathy: effect of Verapamil. J Am Coll Cardiol 9:1108–1116.
Fouad FM, Slominski JM, Tarazi RC (1984) Left ventricular diastolic function in hypertension: relation to left ventricular mass and systolic function. J Am Coll Cardiol 3:1500–1506.
Iskandrian AS, Helfeld H, Lemlek J, Lee J, Iskandrian B, Heo J (1992) Differentiation between primary dilated cardiomyopathy and ischemic cardiomyopathy based on right ventricular performance. Am Heart J 123:768–773.
Schoolmeester WL, Simpson AG, Sauerbrunn BJ, Fletcher RD (1981) Radionuclide angiographic assessment of left ventricular function during exercise in patients with a severely reduced ejection fraction. Am J Cardiol 47:804–809.
Bonow RO, Rosing DR, Bacharach SL et al. (1981) Effects of Verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 64:787–796.
Schwartz RG, McKenzie WB, Alexander J et al. (1987) Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy: seven-year experience using serial radionuclide angiocardiography. Am J Med 82:1109–1118.
Mitani I, Jain D, Joska TM, Burtness B, Zaret BL (2003) Doxorubicin cardiotoxicity: prevention of congestive heart failure with serial cardiac function monitoring with equilibrium radionuclide angiocardiography in the current era. J Nucl Cardiol 10:132–139.
Alexander J, Dainiak N, Berger HJ et al. (1979) Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography. N Engl J Med 300:278–283.
Nousiainen T, Jantunen E, Vanninen E, Hartikainen J (2002) Early decline in left ventricular ejection fraction predicts doxorubicin cardiotoxicity in lymphoma patients. Br J Cancer 86:1697–1700.
Kriss JP, Enright LP, Hayden WG, Wexler L, Shumway NE (1972) Radioisotopic angiocardiography: findings in congenital heart disease. J Nucl Med 13:31–40.
Gal R, Port SC (1987) Radionuclide angiography in congenitally corrected transposition of the great vessels in an adult. J Nucl Med 28:116–118.
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Kumar, R. (2009). Multiple Gated Equilibrium Blood Pool Imaging (MUGA). In: Movahed, A., Gnanasegaran, G., Buscombe, J., Hall, M. (eds) Integrating Cardiology for Nuclear Medicine Physicians. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78674-0_29
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DOI: https://doi.org/10.1007/978-3-540-78674-0_29
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