Skip to main content

Myocardial Perfusion Scintigraphy in Acute Chest Pain: Current Status and Limitations

  • Chapter
Integrating Cardiology for Nuclear Medicine Physicians
  • 1769 Accesses

Abstract

Patients with acute chest pain or symptoms suggestive of myocardial ischemia account for a large number of emergency department (ED) visits, approximately 7 million every year in the USA. Over 5 million of these patients are admitted to the hospital [1]. However, only a minority of these patients have symptoms truly due to ischemic heart disease. The remainder does not require admission to the hospital and may cause a tremendous strain on limited economic resources. When the symptoms are classic and accompanied by diagnostic electrocardiographic changes, the diagnosis of acute coronary syndrome is straightforward. However, in patients with non-diagnostic ECG changes and classic or non-classic symptoms, appropriate decision making becomes more difficult. This dilemma has led to the exploration of newer diagnostic methods to appropriately risk-stratify patients in a cost-effective and time-sensitive manner.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kontos MC, Wackers FJ (2004) Acute rest myocardial perfusion imaging for chest pain. J Nucl Cardiol 11(4):470–481.

    Article  PubMed  Google Scholar 

  2. Carr EA Jr, Beierwaltes WH, Wegst AV, Bartlett JD Jr (1962) Myocardial scanning with rubidium-86. J Nucl Med 3:76–82.

    PubMed  Google Scholar 

  3. Carrea JR, Gleason G, Shaw J, Krontz B (1964) The direct diagnosis of myocardial infarction by photoscanning after administration of cesium-131. Am Heart J 68:627–636.

    Article  PubMed  CAS  Google Scholar 

  4. Romhilt DW, Adolph RJ, Sodd VJ et al. (1973) Cesium-129 myocardial scintigraphy to detect myocardial infarction. Circulation 48(6):1242–1251.

    PubMed  CAS  Google Scholar 

  5. Wackers FJ, Lie KI, Liem KL et al. (1978) Thallium-201 scintigraphy in unstable angina pectoris. Circulation 57(4):738–742.

    PubMed  CAS  Google Scholar 

  6. van der Wieken LR, Kan G, Belfer AJ et al. (1983) Thallium-201 scanning to decide CCU admission in patients with non-diagnostic electrocardiograms. Int J Cardiol 4(3):285–299.

    Article  PubMed  Google Scholar 

  7. Mace SE (1989) Thallium myocardial scanning in the emergency department evaluation of chest pain. Am J Emerg Med 7(3):321–328.

    Article  PubMed  CAS  Google Scholar 

  8. Henneman PL, Mena IG, Rothstein RJ, Garrett KB, Pleyto AS, French WJ (1992) Evaluation of patients with chest pain and nondiagnostic ECG using thallium-201 myocardial planar imaging and technetium-99m first-pass radionuclide angiography in the emergency department. Ann Emerg Med 21(5):545–550.

    Article  PubMed  CAS  Google Scholar 

  9. Okada RD, Glover D, Gaffney T, Williams S (1988) Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation 77(2):491–498.

    PubMed  CAS  Google Scholar 

  10. Bilodeau L, Theroux P, Gregoire J, Gagnon D, Arsenault A (1991) Technetium-99m sestamibi tomography in patients with spontaneous chest pain: correlations with clinical, electrocardiographic and angiographic findings. J Am Coll Cardiol 18(7):1684–1691.

    PubMed  CAS  Google Scholar 

  11. Varetto T, Cantalupi D, Altieri A, Orlandi C (1993) Emergency room technetium-99m sestamibi imaging to rule out acute myocardial ischemic events in patients with nondiagnostic electrocardiograms. J Am Coll Cardiol 22(7):1804–1808.

    PubMed  CAS  Google Scholar 

  12. Hilton TC, Thompson RC, Williams HJ, Saylors R, Fulmer H, Stowers SA (1994) Technetium-99m sestamibi myocardial perfusion imaging in the emergency room evaluation of chest pain. J Am Coll Cardiol 23(5):1016–1022.

    PubMed  CAS  Google Scholar 

  13. Tatum JL, Jesse RL, Kontos MC et al. (1997) Comprehensive strategy for the evaluation and triage of the chest pain patient. Ann Emerg Med 29(1):116–125.

    Article  PubMed  CAS  Google Scholar 

  14. Kontos MC, Jesse RL, Schmidt KL, Ornato JP, Tatum JL (1997) Value of acute rest sestamibi perfusion imaging for evaluation of patients admitted to the emergency department with chest pain. J Am Coll Cardiol 30(4):976–982.

    Article  PubMed  CAS  Google Scholar 

  15. Heller GV, Stowers SA, Hendel RC et al. (1998) Clinical value of acute rest technetium-99m tetrofosmin tomographic myocardial perfusion imaging in patients with acute chest pain and nondiagnostic electrocardiograms. J Am Coll Cardiol 31(5):1011–1017.

    Article  PubMed  CAS  Google Scholar 

  16. Kontos MC, Jesse RL, Anderson FP, Schmidt KL, Ornato JP, Tatum JL (1999) Comparison of myocardial perfusion imaging and cardiac troponin I in patients admitted to the emergency department with chest pain. Circulation 99(16):2073–2078.

    PubMed  CAS  Google Scholar 

  17. Verani MS, Jeroudi MO, Mahmarian JJ et al. (1988) Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol 12(6):1573–1581.

    PubMed  CAS  Google Scholar 

  18. Kontos MC, Kurdziel K, McQueen R et al. (2002) Comparison of 2-dimensional echocardiography and myocardial perfusion imaging for diagnosing myocardial infarction in emergency department patients. Am Heart J 143(4):659–667.

    Article  PubMed  Google Scholar 

  19. Kontos MC, Fratkin MJ, Jesse RL, Anderson FP, Ornato JP, Tatum JL (2004) Sensitivity of acute rest myocardial perfusion imaging for identifying patients with myocardial infarction based on a troponin definition. J Nucl Cardiol 11(1):12–19.

    Article  PubMed  Google Scholar 

  20. Lee KL, Woodlief LH, Topol EJ et al. (1995) Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41,021 patients. GUSTO-I Investigators. Circulation 91(6):1659–1668.

    PubMed  CAS  Google Scholar 

  21. Fioretti P, Sclavo M, Brower RW, Simoons ML, Hugenholtz PG (1985) Prognosis of patients with different peak serum creatine kinase levels after first myocardial infarction. Eur Heart J 6(6):473–478.

    PubMed  CAS  Google Scholar 

  22. White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ (1987) Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 76(1):44–51.

    PubMed  CAS  Google Scholar 

  23. Sabia P, Afrookteh A, Touchstone DA, Keller MW, Esquivel L, Kaul S (1991) Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction. A prospective study using two-dimensional echocardiography. Circulation 84(3 Suppl):I85–I92.

    PubMed  CAS  Google Scholar 

  24. Miller TD, Christian TF, Hopfenspirger MR, Hodge DO, Gersh BJ, Gibbons RJ (1995) Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. Circulation 92(3):334–341.

    PubMed  CAS  Google Scholar 

  25. Miller TD, Hodge DO, Sutton JM et al. (1998) Usefulness of technetium-99m sestamibi infarct size in predicting posthospital mortality following acute myocardial infarction. Am J Cardiol 81(12):1491–1493.

    Article  PubMed  CAS  Google Scholar 

  26. Christian TF, Behrenbeck T, Gersh BJ, Gibbons RJ (1991) Relation of left ventricular volume and function over one year after acute myocardial infarction to infarct size determined by technetium-99m sestamibi. Am J Cardiol 68(1):21–26.

    Article  PubMed  CAS  Google Scholar 

  27. Christian TF, Behrenbeck T, Pellikka PA, Huber KC, Chesebro JH, Gibbons RJ (1990) Mismatch of left ventricular function and infarct size demonstrated by technetium-99m isonitrile imaging after reperfusion therapy for acute myocardial infarction: identification of myocardial stunning and hyperkinesia. J Am Coll Cardiol 16(7):1632–1638.

    Article  PubMed  CAS  Google Scholar 

  28. Behrenbeck T, Pellikka PA, Huber KC, Bresnahan JF, Gersh BJ, Gibbons RJ (1991) Primary angioplasty in myocardial infarction: assessment of improved myocardial perfusion with technetium-99m isonitrile. J Am Coll Cardiol 17(2):365–372.

    PubMed  CAS  Google Scholar 

  29. Weissman IA, Dickinson CZ, Dworkin HJ, O’Neill WW, Juni JE (1996) Cost-effectiveness of myocardial perfusion imaging with SPECT in the emergency department evaluation of patients with unexplained chest pain. Radiology 199(2):353–357.

    PubMed  CAS  Google Scholar 

  30. Radensky PW, Hilton TC, Fulmer H, McLaughlin BA, Stowers SA (1997) Potential cost effectiveness of initial myocardial perfusion imaging for assessment of emergency department patients with chest pain. Am J Cardiol 79(5):595–599.

    Article  PubMed  CAS  Google Scholar 

  31. Stowers SA, Eisenstein EL, Th Wackers FJ et al. (2000) An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: results from a randomized trial. Ann Emerg Med 35(1):17–25.

    Article  PubMed  CAS  Google Scholar 

  32. Kontos MC, Schmidt KL, McCue M et al. (2003) A comprehensive strategy for the evaluation and triage of the chest pain patient: a cost comparison study. J Nucl Cardiol 10(3):284–290.

    Article  PubMed  Google Scholar 

  33. Udelson JE, Beshansky JR, Ballin DS et al. (2002) Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia: a randomized controlled trial. J Am Med Assoc 288(21):2693–2700.

    Article  Google Scholar 

  34. Chikamori T, Fujita H, Nanasato M, Toba M, Nishimura T (2005) Prognostic value of I-123 15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid myocardial imaging in patients with known or suspected coronary artery disease. J Nucl Cardiol 12(2):172–178.

    Article  PubMed  Google Scholar 

  35. Tamaki N (2005) Role of BMIPP imaging for risk stratification in patients with coronary artery disease. J Nucl Cardiol 12(2):148–150.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Velappan, P., Movahed, A. (2009). Myocardial Perfusion Scintigraphy in Acute Chest Pain: Current Status and Limitations. In: Movahed, A., Gnanasegaran, G., Buscombe, J., Hall, M. (eds) Integrating Cardiology for Nuclear Medicine Physicians. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78674-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-78674-0_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78673-3

  • Online ISBN: 978-3-540-78674-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics