Is Fever Beneficial?
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#x203A; Fever has a long evolutionary history, which by itself supports the hypothesis that fever is an adaptive host response to infection.
› There is considerable evidence that fever promotes host defense against infection.
› Complications and mortality associated with high fever >40°C are closely related to the severity of the underlying disease, not to the level of fever.
› Fever is effectively controlled by the hypothalamic centre and therefore does not climb up relentlessly. Temperatures >42°C are often caused by hyperthermia, not by fever.
› If the febrile child is comfortable, there is little reason to support the practice of routine use of antipyretic medication.
› Parental education is critical in the management of the febrile child.
› Antipyretics do not prevent febrile seizures.
› There is a conflict between research evidence supporting a positive role of fever and the demands of current practice that fever be abolished.
KeywordsFebrile Seizure Sodium Salicylate Febrile Episode Febrile Convulsion Febrile Child
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- 1.Kluger MJ, Kozak W, Mayfield KP. Fever and Immunity, in Psychoneuroimmunology, Third Edition, Vol. 1, Academic Press, San Diego. 2001, pp. 687–702Google Scholar
- 4.Yerushalmi A, Lwoff A. Traitment du coryza infectieux et des rhinitis persistantes allergiques par la thermotherapie. Comp Rendus Seances. Acad Sci (Ser D) 1980; 291: 957–9Google Scholar
- 11.Heron I, Berg K, Cantel K. Regulatory effect of interferon on T cell in vitro. J Immunol 1976; 17: 1370–3Google Scholar
- 16.Graham NH, Burrell CJ, Douglas RM, et al. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding and clinical status in rhinovirus-infected vol unteers. Infect Dis 1990; 162: 1277–82Google Scholar
- 19.Muschenheim C, Duerschrer DR, Hardy JD, et al. Hypothermia in experimental infections. Infect Dis 1943; 72: 187–96Google Scholar
- 20.Husseini RH, Sweet C, Collie MH, et al. Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence. Infect Dis 1982; 145: 520–4Google Scholar
- 23.Custovic A. The hygiene hypothesis revisited: pros and cons. Asthma and immunology 60th anniversary meeting, Denver, Colorado, March 7–12, 2003Google Scholar
- 28.Rosman N P. Febrile Convulsions, in Fever: Basic Mechanisms and Management, Second Edition, edited by P.A. Mackowiak. Lippincot, Philadelphia. 1997, pp. 267–77Google Scholar
- 32.Van Stuijvenberg M, Derksen-Lubsen G, Steyerberg E W, et al. Randomized, controlled trial of ibuprofen syrup administered during febrile illnesses to prevent febrile recurrences. Pedi atrics 1998; 102: 1–7Google Scholar
- 34.Meremikwu M, Oyo-Ita A. Paracetamol for treating fever in children. Cochrane Database Syst Rev 2002; 4Google Scholar