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Immunologische Konsequenzen, Rheuma, Infektionen

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Entry Inhibitoren

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Auszug

Die Blockade des Chemokinrezeptors 5 (CCR5) durch kleinmolekulare CCR5-Inhibitoren wie Maraviroc hat neue Möglichkeiten für die Therapie von CCR5-tropen HI-Viren eröffnet. Da Chemokinrezeptoren eine wichtige Rolle in der Immunantwort spielen, stellt sich natürlich die Frage, welche Folgen eine pharmakologische Blockade von CCR5 für die Abwehr von Infektionen und die Entstehung von entzündlichen Erkrankungen haben kann. Ein gutes Verständnis der Rolle des Chemokin-Chemokinrezeptor-Systems ist daher entscheidend für die Abschätzung der Konsequenzen einer pharmakologischen Intervention.

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  1. Medizinische Klinik III, Universitätsklinikum Erlangen, Krankenhausstr. 12, 91054, Erlangen

    Thomas Harrer

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  1. Thomas Harrer
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  1. MVZ Karlsplatz, Stachus 8, 80335, München

    Hans Jäger

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© 2008 Springer Medizin Verlag Heidelberg

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Harrer, T. (2008). Immunologische Konsequenzen, Rheuma, Infektionen. In: Jäger, H. (eds) Entry Inhibitoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78358-9_14

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  • DOI: https://doi.org/10.1007/978-3-540-78358-9_14

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