Abstract
Congenital or acquired anatomical abnormalities of the penis may interfere with cohabitation and normal deposition of semen. These congenital anatomical variations especially include abnormal position of the urethral meatus (hypospadias/epispadias), but also, penile deviations due to induratio penis plastica (IPP; Peyronie's disease) which represents the most common clinical problem.
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References
Altinkilic B, Hauck EW, Weidner W (2004) Evaluation of penile perfusion by color-coded duplex sonography in the management of erectile dysfunction. World J Urol 22:361–364
American Urological Association (AUA) (2005) Management of erectile dysfunction. Website http://www.auanet.org/ guidelines
Bannowsky A, Schulze H, van der Horst C, Hautmann S, Juenemann KP (2008) Recovery of erectile function after nerve-sparing radical prostatectomy: improvement with nightly low-dose sildenafil. BJU 101:1279–1283
Behre HM (2004) Testosterone and erection. In: Nieschlag E, Behre HM (eds) Testosterone — action, deficiency and substitution, 3rd edn. Cambridge University Press, Cambridge, pp 333–346
Bella AJ, Perelman MA, Brant WO, Lue TF (2007) Peyronie's disease (CME). J Sex Med 4:1527–1538
Biagiotti G, Cavallini G (2001) Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report. BJU Int 88:63–67
Blount MA, Beasley A, Zoraghi R, Sekhar KR, Bessay EP, Francis SH, Corbin JD (2004) Binding of tritiated sildenafil, tadalafil or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol 66:144–152
Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U (2000) Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’. Int J Impot Res 12:305–311
Briganti A, Salonia A, Gallina A, Chun FKH, Karakiewicz PI, Graefen M, Huland H, Rigatti P, Montorsi F (2007) Management of erectile dysfunction after radical prostatectomy in 2007. World J Urol 25:143–148
Brock G, Tu LM, Linet OI (2001) Return of spontaneous erections during long term intracavernosal alprostadil (Caverject) treatment. Urology 57:536–541
Burnett AL (2004) Novel nitric oxide signaling mechanisms regulate the erectile response. Int J Impot Res 16(1): S15–S19
Carson CC, Rajfer J, Eardley I, Carrier S, Denne JS, Walker DJ, Shen W, Cordell WH (2004) The efficacy and safety of tada-lafil: an update. BJU Int 93:1276–1281
Colpi GM, Fanciullacci F, Aydos K, Grugnetti C (1991) Effectiveness mechanism of chlomipramine by neurophysi-ological tests in subjects with true premature ejaculation. Andrologia 23:45–47
Cookson MS, Nadig PW (1993) Long-term results with vacuum constriction device. J Urol 149:290–294
Davis–Joseph B, Tiefer L, Melman A (1995) Accuracy of the initial history and physical examination to establish the etiology of erectile dysfunction. Urology 45:498–502
Del Popolo G, Li Marzi V, Mondaini N (2002) Time/duration effectiveness of sildenafil versus tadalafil in the treatment of erectile dysfunction in male spinal-cord injured patients. Spinal Cord 42:643–648
Denil J, Ohl DA, McGuire EJ, Jonas U (1992) Treatment of ane– jaculation with electroejaculation. Acta Urol Belg 60:15–25
Derouet H, Zehl U (1990) Die Behandlung der erektilen Dys-funktion mittels Vakuumsaugpumpen (EHS). Urologe A 32:312–315
Dettmers C, Ahlen H van, Faust H, Fatepour D, Tackmann W (1994) Evaluation of erectile dysfunction with the sympathetic skin response in comparison to bulbocavernosus reflex and somatosensory evoked potentials of the pudendal nerve. Electromyogr clin Neurophysiol 34:437–444
Droggin D, Shabsigh R, Anastasiadis G (2005) Antibiotic coating reduces penile prosthesis infection. J Sex Med 2:565–568
Ernst E, Pittler MH (1998) Yohimbine for erectile dysfunction: a systematic review and meta—analysis of randomized clinical trials. J Urol 159:433–436
Fabbri A, Jannini EA, Gnessi L, Moretti C, Ulisse S, Franzese A, Lazzari R, Fraioli F, Frajese G, Isidori A (1989) Endorphins in male impotence: evidence for naltrexone stimulation of erectile activity in patient therapy. Psychoneu-roendocrinology 14:103–111
FDA (2007) FDA proposes new warnings about suicidal thinking, behavior in young adults who take andidepressant medications. FDA news: http//69.20.19.211/bbs/topics/NEWS/2007
Feldmann HA, Goldstein I, Hatzichriston DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psycho-social correlates: results of the Massachusetts Male Aging Study. J Urol 151:54–61
Goldstein I, Lue TF, Padma-Nathan H for the Sildenafil Study Group (1998) Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338:1397–1404
Golijanin D, Singer E, Davis R, Bhatt S, Seftel A, Dogra V (2007) Doppler evaluation of erectile dysfunction. Int J Impot Res 19:37–48
Gorkin L, Hvidsten K, Sobel RE, Siegel R (2006) Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy. Int J Clin Pract 60:500–503
Greenstein A, Plymate SR, Katz PG (1995) Visually stimulated erection in castrated men. J Urol 153:650–652
Grein U, Noll F, Schreiter F (1989) Behandlung der erektilen Dysfunktion mit Penisprothesen. Urologe A 28:266–270
Hartmann U, Langer D (1993) Combination of psychosexual therapy and intrapenile injections in the treatment of erectile dysfunctions: rationale and predictors of outcome. J Sex Educ Ther 19:1–12
Hatzichristou DG, Suenz de Tejada I, Kupferman S, Namburi S, Pescatore ES, Udelson D, Goldstein I (1995) In vivo assessment of trabecular smooth muscle tone, its application in pharmaco–cavernosometry and analysis of intracavernous pressure determinents. J Urol 153:1126–1135
Hauck EW, Diemer T, Weidner W (2006) Induratio penis plas-tica. Urologe 45:243–259
Hauri D (1984) Therapiemöglichkeiten bei der vaskulär bed-ingten erektilen Impotenz. Akt Urol 15:350–354
Heaton JPW, Morales A, Adams MA, Johnston B, El-Radhidy R (1995) Recovery of erectile function by the oral administration of apomorphine. Urology 45:200–206
Hellstrom WJG (2007) Current safety and tolerability issues in men with erectile dysfunction receiving PDE-5 inhibitors. Int J Clin Pract 61:1547–1554
Jackson G, Montorsi P, Cheitlin M (2006a) Cardiovascular safety of sidenafil citrate (Viagra): an updated perspective. Urology 68:47–60
Jackson G, Rosen RC, Kloner RA, Kostis JB (2006b) The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. J Sex Med 3:28–36
Jardin A, Wagner G, Khoury S, Giuliano F, Padma-Nathan H, Rosen R (eds) (2000) Erectile dysfunction. Health Publication Ltd., Plymouth, UK, pp 711–726
Kamischke A, Nieschlag E (1999) Treatment of retrograde ejaculation and anejaculation. Hum Reprod Update 5:448–474
Kaneko S, Bradley WA (1987) Penile electrodiagnosis: penile peripheral innervation. Urology 30:210–213
Kelami A (1985) Congenital penile deviation and straightening of the penis using the Nesbit–Kelami technique. Urol Int 40:267–268
Kim ED, McVary KT (1995a) Long–term follow up of treatment of Peyronie's disease with plaque incision, carbon dioxide laser plaque ablation and placement of a deep dorsal vein patch graft. J Urol 153:1843–1846
Kim ED, McVary KT (1995b) Long–term results with penile vein ligation for venogenic impotence. J Urol 153:655–658
Kim SC, Seo KK (1998) Efficacy and safety of fluoxetine, sertra-line and clomipramine in patients with premature ejaculation: a double blind, placebo controlled study. J Urol 159:425–427
Kloner R (1999) Safety of sildenafil citrate in men with erectile dysfunction taking multiple antihypertensive agents. Am J Hypertens 12:37
Kloner R, Jackson G, Hutter AM, Mittleman MA, Chan M, Warner M, Costigan TM, Vail GM (2006) Cardiovascular safety update of tadalafil: retrospective analysis of data from placebo-controlled and open-label clinical trials of tadalafil with as needed, three times-per-week or once-a-day dosing. Am J Cardiol 97:1778–1784
Kloner RA, Speakman M (2002) Erectile dysfunction and atherosclerosis. Curr Atheroscler Rep 5:397–401
Klotz T, Bauer RJ, Rohde G (2002) Effect of renal impairment on the single-dose pharmacokinetics of vardenafil 20 mg, a selective PDE-5 inhibitor, for the treatment of erectile dysfunction. Pharmacotherapy 22:418
Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL, Carson III C, Cheitlin M, Debusk R, Fonseca V, Ganz P, Goldstein I, Guay A, Hatzichristou D, Hollander JE, Hutter A, Katz S, Kloner RA, Mittleman M, Montorsi F, Montorsi P, Nehra A, Sadovsky R, Shabsigh R (2005) Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol 96:313–321
Lavoisier P, Proulx J, Courtois F, De CF (1989) Bulbocavernosus reflex: its validity as a diagnostic test of neurogenic impotence. J Urol 141:311–314
Lawrence S, Madakasira S (1992) Evaluation and treatment of premature ejaculation: a critical review. Int J Psychiatry Med 22:77–97
Lemourt OM, Filgueiras LE, Rodriguez BA, Gonzalez OE, Bordonado R (1998) Clinical evaluation of the use of propoleum in Peyronie's disease. Arch Esp Urol 51:171–176
Lue TF, Tanagho EA (1987) Physiology of erection and pharmacological management of impotence. J Urol 137:829–836
Masters WH, Johnson VE (1970) Human sexual inadequacy. Little, Brown, Boston, MA
McMahon CG, Abdo C, Incrocci L, Perelman M, Rowland D, Waldinger M, Xin ZC (2004) Disorders of orgasm and ejaculation in men. J Sex Med 1:58–65
Mittleman MA, Maclure M, Glasser DB (2005) Evaluation of acute rsik for myocardial infarction in men treated with sildenafil citrate. Am J Cardiol 96:443–446
Moldings GJ, van Ahlen H, Göthert M (1992) Modulation of noradrenaline release in human corpus cavernosum by pre-synaptic protaglandin receptors. Int J Impotence Res 4:19–25
Montorsi F, Guazzoni G, Strambi LF (1997) Recovery of spontaneous erectile function after nerve-sparing retropubic radical prostatectomywith and without early intracavernous injections of alprostadil: results of a prospective, randomised trial. J Urol 158:1408–1410
Montorsi F, Brock G, Lee J, Shapiro J, van Poppel H, Graefen M, Stief C (2008) Effect of nightly versus on-demand vard-enafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol 54:924–931
Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A, Rigatti P, Montorsi F (2005) The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 96:19M–23M.
Morales A, Condra M, Reid K (1990) The role of nocturnal penile tumescence monitoring in the diagnosis of impotence: a review. J Urol 143:441–446
Mulhull J, Montorsi F (2006) Evaluating preference trials of oral phosphodiesterase 5 inhibitors for erectile dysfunction. Eur Urol 49:30–37
Mulhull J, Land S, Parker M, Waters WB, Flanigan RC (2005) The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2:532–545
Mulhull JP, Simmons J (2007) Assessment of comparative treatment satisfaction with sildenafil citrate and penile injection therapy in patients responding to both. BJU Int 100:1313–1316
Nathalie A, Olianas R, Fisch M (2008) Penile implantation in Europe: successes and complications with 253 implants in Italy and Germany. J Sex Med 5:1503–1512
Nesbit RM (1954) The surgical treatment of of congenital chordee without hypospadias. J Urol 72:1178–1180
Oates CP, Pickard RS, Powell PH, Murthy LNS, Whittingham TAW (1995) The use of duplex ultrasound in the assessment of arterial supply to the penis in vasculogenic impotence. J Urol 153:354–357
Padma-Nathan H (2006) Sildenafil Citrate (Viagra) treatment for erectile dysfunction: an updated profile of response and effectiveness. Int J Impot Res 18:423–431
Padma-Nathan H, Hellstrom WJ, Kaiser FE, Labasky RF, Lue TF, Nolten WE, Norwood PC, Peterson CA, Shabsigh R, Tam PY (1997) Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med 336:1–7
Patterson B, Bedding A, Hayley J, Payne C, Mitschell M (2002) Dose normalised pharmacokinetics of tadalafil administered as a single dose to healthy volunteers. Eur Urol Suppl. 1:152, Abstract 600
Pickering TG, Shepherd AM, Puddey I (2004) Sildenafil citrate for erectile dysfunction in men receiving multiple antihyper-tensive agents: a randomized controlled trial. Am J Hypertens 14:70–73
Porst H (1990) Diagnostic use and side effects of vasoactive drugs — a report on over 2,100 patients with erectile failure. Int J Impotence Res 2(2):222–223
Porst H, van Ahlen H (1989) Drug-induced priapism — a report of experiences in 101 cases. Urologe 28:84–87
Porst H, Weller S (1989) Vasoaktive Substanzen bei erektiler Dysfunktion (ED) — Ergebnisse einer Umfrage und Litera-turübersicht. Urologe B 29:10–14
Porst H, Ahlen H van, Köster O, Schlolaut KH (1988a) Vergleich von Papaverin-induzierter Doppler-Sonographie und Angiog-raphie in der Diagnostik der erektilen Dysfunktion. Urologe A 27:8–13
Porst H, Tackmann W, Ahlen H van (1988b) Neurophysiological investigations in potent and impotent men. Assessment of bulbocavernosus reflex latencies and somatosensory evoked potentials. Br J Urol 61:445–450
Porst H, Rajfer J, Casabé A, Feldman R, Ralph D, Vieiralves LF, Esler A, Wolka AM, Klise SR (2008) Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction. J Sex Med 5:2160–2169
Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S (2006) Efficacy and tol-erability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double blind, randomised controlled trials. Lancet 368:929–937
Rajfer J, Aliotta PJ, Steidle CP, Fitch III WP, Zhao Y, Yu A (2007) Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double–blind, placebo-controlled study in the US. Int J Impot Res 19:95–103
Ralph D, Eardley I, Kell P, Dean J, Hackett G, Collins O, Edwards D (2007) Improvement in erectile function on vard-enafil treatment correlates with treatment satisfaction in both patients and their partners. BJU Int 100:130–136
Rhee E, Osborn A, Witt M (1995) The correlation of cavernous systolic occlusion pressure with peak velocity flow using color duplex doppler ultrasound. J Urol 153:358–360
Robert A, Kloner RA, Mohan P, Norenberg C (2002) Cardiovascular safety of vardenafil, a potent, highly selective PDE-5 inhibitor in patients with erectile dysfunction: an analysis of five placebo-controlled clinical trials. Pharmacol Ther 22:1371–1375
Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M (2004) Men's Attitudes to Life Events and Sexuality (MALES) Study. I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 20:607–617
Rosen RC, Fisher WA, Beneke M, Homering M, Evers T (2007) The COUPLES-project: a pooled analysis of patient and partner treatment satisfaction scale (TSS) outcomes following vardenafil treatment. BJU Int 99:849–859
Rosenberg MT (2007) Diagnosis and managment of erectile dysfunction in the primary care setting. Int J Clin Pract 61:1198–1208
Rubio-Aurioles E, Porst H, Eardley I, Goldstein I (2006) Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomised, double-blind, pooled crossover study. J Sex Med 3:1037–1049
Safarinejad MR (2004) Therapeutic effects of colchicines in the management of Peyronie's disease: a randomized double-blind, placebo-controlled study. Int J Impot Res 16:238–243
Safarinejad MR (2007) Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo controlled, fixed dose, randomised study. J Clin Psychopharmacol 27:444–450
Safarinejad MR, Hosseini SY, Kolahi AA (2007) Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. J Urol 178:1398–1403
Sairam K, Kulinskaya E, Boustead GB, Hanbury DC, McNicholas TA (2001) Prevalence of undiagnosed diabetes mellitus in male erectile dysfunction. BJU Int 88:68–71
Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA (2008) Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med 5:188–193
Scott FB, Bradley WE, Timm GW (1973) Management of erectile impotence: use of implantable inflatable prosthesis. Urology 2:80–82
Seftel A (2004) Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic and efficacy pro-files. Clin Cardiol 27:14–19
Small MP, Carrion HH (1975) A new penile prosthesis for treating impotence. Contemp Surg 7:29–33
Sohn M, Sikora RR, Bohndorf KK, Wein B, Zabelberg U, Jakse G (1992) Objective follow-up after penile revascularisation. Int J Impot Res 4:73–84
Stanley EA, Rowland DL (2008) Identifying constructs and criteria for the diagnosis of premature ejaculation: implication for making errors of classification. BJU Int 102:708–712
Stief CG (1993) Diagnostik und Therapie der erektilen Dysfunktion. Internist 34:767–774
Teloken C, Rhoden EL, Grazziotin TM, Ros CT, Sogari PR, Souto CA (1999) Tamoxifen versus placebo in the treatment of Peyronie's disease. J Urol 162:2003–2005
Valiquette L, Montorsi F, Auerbach S (2008) Vardenafil demonstrates first-dose success and reliability of penetration and maintenance of erection in men with erectile dysfunction – RELY-II. Can Urol Assoc J 2:187–195
van Ahlen H, Peskar BA, Sticht G, Hertfelder HJ (1994) Pharmacokinetics of vasoactive substances administered into the human corpus cavernosum. J Urol 151:1227–1230
van Ahlen H, Piechota HJ, Kias HJ, Brennemann W, Klingmüller D (1995) Opiate antagonists in erectile dysfunction: a possible new treatment option. Eur Urol 28:246–250
van Ahlen H, Wahle K, Kupper W, Yassin A, Reblin T, Neureither M (2005) Safety and efficacy of vardenafil, a selective phos-phodiesterase 5 inhibitor in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives. J Sex Med 2:856–864
Virag R, Zwang G, Dermange H, Legman M (1981) Vasculogenic impotence: a review of 92 cases with 54 surgical operations. Vasc Surg 15:9–15
Vogt HJ, Brandl P, Kockott G, Schmitz JR, Wiegand MH, Schadrack J (1997) Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonor-ganic erectile dysfunction. Int J Impot Res 9:155–161
Wegner HEH, Andresen R, Knispel HH, Banzer D, Miller K (1995) Evaluation of penile arteries with color-coded duplex sonography: prevalence and possible therapeutic implications of connections between dorsal and cavernous arteries in impotent men. J Urol 153:1469–1471
Weidner W, Hauck EW, Schnitker J (2005) Peyronie's disease study group of andrological group of German urologists. Eur Urol 47:530–535
Wilson SK, Delk J, Neeb A, Cleves M (2006) Long term survival of inflatable penile prostheses: single surgical group experience with 2,384 first time implants spanning two decades. J Urol 174:1304
Zumbé J, Porst H, Sommer F, Grohmann W, Beneke M, Ulbrich E (2008) Comparable efficacy of once-daily versus on–demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE Study. Eur Urol 54:204–212
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Ahlen, H.v., Kliesch, S. (2010). Disorders of Erection, Cohabitation, and Ejaculation. In: Nieschlag, E., Behre, H.M., Nieschlag, S. (eds) Andrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78355-8_16
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