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Tumour and Tumour-like Conditions Associated with Paget’s Disease of Bone

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Book cover Imaging of Bone Tumors and Tumor-Like Lesions

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Key Points

• Fewer than 5% of patients with Paget’s disease will undergo malignant transformation to a sarcoma.

• The risk of a patient developing a sarcoma is greater the more extensive the Paget’s disease and the longer the patient has been affected.

• Paget’s sarcoma may appear photopenic (“cold”) on bone scintigraphy against a background of increased activity from the surrounding pagetic bone.

• Not all malignancies arising in Paget’s disease are a sarcoma. Metastases, myeloma and lymphoma should be considered in the differential diagnosis.

• There is a rare recognised association between Paget’s disease and giant cell tumour of bone typically involving the skull and facial bones.

• The preservation of the normal hyperintense signal of marrow fat on T1-weighted MR images is typical of uncomplicated Paget’s disease in all its stages. The loss of this hyperintense signal is seen when complications arise, including tumour, occult fractures, etc.

• The worldwide prevalence of Paget’s disease in the population appears to be decreasing.

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Authors and Affiliations

  1. Department of Radiology, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    A. Mark Davies

  2. Service de Radiologie B, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75679, Paris Cedex, France

    Etienne Pluot

  3. Department of Radiology, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    Steven L. J. James

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  1. A. Mark Davies
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Editors and Affiliations

  1. MRI Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    A. Mark Davies

  2. Section of Musculoskeletal Radiology, Imaging Institute, Diagnostic Radiology/A21, School of Medicine of Case Western Reserve University, Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Murali Sundaram

  3. Imaging Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    Steven L. J. James

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Davies, A., Pluot, E., James, S. (2009). Tumour and Tumour-like Conditions Associated with Paget’s Disease of Bone. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_29

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