Key Points
• There are several unrelated types of bone cyst. Simple (unicameral) bone cysts (SBCs) are most commonly found in the proximal humerus and proximal femur in children, and also occur in the calcaneum in adults.
• They tend to present with pathological fracture, which may lead to healing of the lesion. Aneurysmal bone cysts (ABC) are often markedly expansile lesions, which may grow rapidly.
• They occur in the appendicular, axial and craniofacial skeleton, typically in children and adolescents and contain multiple blood-filled cysts. A proportion occurs in association with other bone lesions (secondary ABC). SBC and primary
• ABC have long been considered non-neoplastic, but cytogenetic abnormalities found in primary ABCs have suggested that they do represent neoplasms.
• Intraosseous ganglia and geodes are lesions which generally occur in subarticular bone, showing similar imaging and pathological features.
• The distinction is based on the presence of arthropathy, but they probably represent manifestations of the same process.
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References
Adamsbaum C, Kalifa G, Seringe R et al. (1993) Direct Ethibloc injection in benign bone cysts: preliminary report of 4 patients. Skeletal Radiol 22:317–320
Alyas F, Saifuddin A (2008) Fluid-fluid levels in bone neoplasms: variation of T1-weighted signal intensity of the superior to inferior layers: diagnostic significance on magnetic resonance imaging. Eur Radiol (Epub ahead of print)
Alyas F, Tirabosco R, Cannon S et al. (2008) “Fallen fragment sign” in Langerhans’ cell histiocytosis. Clin Radiol 63:92–96
Andresen K, Sundaram M, Unni K (2004) Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol 33:373–379
Bahk W, Kang Y, Rhee S et al. (2007) Cystic fibrous dysplasia in the long bone. Orthopedics 30:871–873
Baig R, Eady J (2006) Unicameral (simple) bone cysts. South Med J 99:966–976
Bhagia S, Grimer R, Davies AM et al. (1997) Ewing’s sarcoma presenting as a solitary bone cyst. Skeletal Radiol 26:722–724
Biesecker J, Marcove R, Huvos A et al. (1970) Aneurysmal bone cysts. A clinicopathologic study of 66 cases. Cancer 26:615–625
Boriani S, De Iure F, Campanacci L et al. (2001) Aneurysmal bone cyst of the mobile spine. Report on 41 cases. Spine 26:27–35
Boseker E, Bickel W, Dahlin D (1968) A clinicopathologic study of simple unicameral bone cysts. Surg Gynecol Obstet 127:550–560
Broder H (1968) Possible precursor of unicameral bone cysts. J Bone Joint Surg [Am] 50-A:503–507
Burnstein M, De Smet A, Hafez G et al. (1990) Case report 611. Skeletal Radiol 19:294–297
Campanacci M, Capanna R, Picci P (1986) Unicameral and aneurysmal bone cysts. Clin Orthop Relat Res 204:25–36
Capanna R, Dal Monte A, Gitelis S et al. (1982) The natural history of unicameral bone cyst after steroid injection. Clin Orthop Relat Res 166:204–211
Capanna R, Albisinni U, Picci P et al. (1985a) Aneurysmal bone cyst of the spine. J Bone Joint Surg [Am] 67-A:527–531
Capanna R, Bettelli G, Biagini P et al. (1985b) Aneurysmal bone cysts of long bones. Ital J Orthop Traumatol 11:409–417
Chang JH, Chang JW, Park Y et al. (2003) Simple bone cyst occurring in calvarium. Acta Neurochir (Wien) 145:927–928
Chigera M, Takehi Y, Nagase M et al. (1987) A case of multiple simple bone cysts with special reference to their etiology and treatment. Arch Orthop Trauma Surg 106:390–393
Cho H, Oh J, Kim H et al. (2007) Unicameral bone cysts. A comparison of injection of steroid and grafting with autologous bone marrow. J Bone Joint Surg [Br] 89-B:222–226
Cohen J (1960) Simple bone cysts:studies of cyst fluid in six cases with a theory of pathogenesis. J Bone Joint Surg [Am] 42-A:609–616
Coskun B, Akpek S, Dogulu F et al. (2004) Simple bone cyst in spinous process of the C4 vertebra. Am J Neuroradiol 25:1291–1293
Crane A, Scarano J (1949) Synovial cysts (ganglia) of bone. Report of 2 cases. J Bone Joint Surg [Am] 49-A:355–361
Dabezies E, D’Ambrosia R, Chuinard R et al. (1982) Aneurysmal bone cyst after fracture. A report of three cases. J Bone Joint Surg [Am] 64A:617–621
Dabska M, Buraczewski J (1969) Aneurysmal bone cyst. Pathology, clinical course and radiologic appearances. Cancer 23:371–389
Dal Cin P, Kozakewich H, Goumnerova L et al. (2000) Variant translocations involving 16q22 and 17p13 in solid variant and extraosseous forms of aneurysmal bone cyst. Genes Chromosomes Cancer 28:233–234
Davids J, Graner K, Mubarak S (1993) Post-fracture lipid inclusion cyst. A case report. J Bone Joint Surg [Am] 75-A:1528–1532
Davies AM, Evans N, Mangham D et al. (2001) MR imaging of brown tumour with fluid-fluid levels: a report of three cases. Eur Radiol 11:1445–1449
De Sanctis N, Andreacchio A (2000) Elastic stable intramedullary nailing is the best treatment of unicameral bone cysts of the long bones in children? Prospective long-term follow-up study. J Pediatr Orthop 26:520–525
De Smet A, Travers H, Neff J (1982) Case report 207. Skeletal Radiol 8:314–318
Donahue F, Turkel D, Mnaymneh W et al. (1996) Intraosseous ganglion cyst associated with neuropathy. Skeletal Radiol 25:675–678
Durr H, Lienemann A, Stabler A et al. (1997) MRI of posttraumatic cyst-like lesions of bone after a greenstick fracture. Eur Radiol 7:1218–1220
Eggers G, Evans E, Blumel J et al. (1963) Cystic change in the iliac acetabulum. J Bone Joint Surg [Am] 45-A:669–722
Feldman F, Johnston A (1973) Intraosseous ganglion. Am J Roentgenol 118:328–343
Fisher A, Totty W, Kyriakos M (1994) Case report. MR appearance of cystic fibrous dysplasia. J Comput Assist Tomogr 18:315–318
Garceau G, Gregory C (1954) Solitary unicameral bone cyst. J Bone Joint Surg [Am] 36-A:267–280
Gebhart M, Blaimont P (1996) Contribution to the vascular origin of the unicameral bone cyst. Acta Orthop Belg 62:137–143
Goldman R, Friedman N (1969) Ganglia (“synovial” cysts) arising in unusual locations. Clin Orthop Relat Res 63:184–189
Goto T, Nemoto T, Okuma T et al. (2007) Mirror-image solitary bone cyst of the humerus in a pair of mirror-image monozygotic twins. Arch Orthop Trauma Surg (Epub ahead of print)
Green J, Bellemore M, Marsden F (1997) Embolization in the treatment of aneurysmal bone cysts. J Pediatr Orthop 17:440–443
Grey A, Mangham D, Davies AM et al. (1997) Fluid-fluid level in an intraosseous ganglion. Skeletal Radiol 26:667–670
Gupta A, Crawford A (1996) Solitary bone cysts with epiphyseal involvement: confirmation with magnetic resonance imaging: a case report and review of the literature. J Bone Joint Surg [Am] 78-A:911–915
Hammoud S, Frassica F, McCarthy E (2006) Ewing’s sarcoma presenting as a solitary cyst. Skeletal Radiol 35:533–535
Hashemi-Nejad A, Cole W (1997) Incomplete healing of simple bone cysts after steroid injections. J Bone Joint Surg [Br] 79-B:727–730
Hay M, Paterson D, Taylor T (1978) Aneurysmal bone cysts of the spine. J Bone Joint Surg [Br] 60-B:406–411
Helwig U, Lang S, Baczynski M et al. (1994) The intraosseous ganglion. A clinical–pathological report on 42 cases. Arch Orthop Trauma Surg 114:14–17
Hudson T (1984) Fluid levels in aneurysmal bone cysts: a CT feature. Am J Roentgenol 141:1001–1004
Ilaslan H, Sundaram M, Unni K (2003) Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. Am J Roentgenol 180:1681–1687
James A, Coley B, Higinbotham N (1948) Solitary unicameral bone cyst. Arch Surg 57:137–147
Kaelin A, MacEwen G (1989) Unicameral bone cysts. Natural history and the risk of fracture. Int Orthop 13:275–282
Kambolis C, Bullough P, Jaffe H (1973) Ganglionic cystic defects of bone. J Bone Joint Surg [Am] 55-A:496–505
Killian J, Wilkinson L, White S et al. (1998) Treatment of unicameral bone cyst with demineralised bone matrix. J Pediatr Orthop 18:621–624
Komiya S, Minamitani K, Sasaguri Y et al. (1993) Simple bone cyst treatment by trepanation and studies on bone resorptive factors in cyst fluid with a theory of its pathogenesis. Clin Orthop Relat Res 287:204–211
Komiya S, Tsuzuki K, Mangham D et al. (1994) Oxygen scavengers in simple bone cysts. Clin Orthop Relat Res 308:199–206
Kyriakos M, Hardy D (1991) Malignant transformation of aneurysmal bone cyst, with an analysis of the literature. Cancer 68:1770–1780
Leithner A, Windhager R, Lang S et al. (1999) Aneurysmal bone cyst. A population based epidemiologic study and literature review. Clin Orthop Relat Res 363:176–179
Levy W, Miller A, Bonakdapour A et al. (1975) Aneurysmal bone cyst secondary to other osseous lesions: report of 57 cases. Am J Clin Pathol 63:1–8
Lichtenstein L (1950) Aneurysmal bone cyst. A pathological entity commonly mistaken for giant-cell tumor and occasionally for hemangioma and osteogenic sarcoma. Cancer 3:279–289
Lokiec F, Ezra E, Khermosh O et al. (1996) Simple bone cysts treated by percutaneous autologous marrow grafting: a preliminary report. J Bone Joint Surg [Br] 78-B:934–937
Magee T, Rowedder A, Degnan G (1995) Intraosseous ganglia of the wrist. Radiology 195:517–520
Mahnken A, Nolte-Ernsting C, Wildberger J et al. (2003) Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol 13:1118–1124
Maiya S, Davies AM, Evans N et al. (2002) Surface aneurysmal bone cysts: a pictorial review. Eur Radiol 12:99–108
Malghem J, Maldague B (1986) Transient fatty cortical defects following fractures in children. Skeletal Radiol 15:369–371
Margau R, Babyn P, Cole W et al. (2000) MR imaging of simple bone cysts in children: not so simple. Pediatr Radiol 30:551–557
Martinez V, Sissons H (1988) Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer 61:2291–2304
May D, McCabe K, Kuivila T (1997) Intraosseous ganglion in a 6-year-old boy. Skeletal Radiol 26:67–9
Menges V, Prager P, Cserhati M et al. (1977) Das intraossäre Ganglion. Z Orthop 115:67–75
Mirra J (1989a) Simple bone cyst. In: Mirra J, Picci P, Gold R (eds) Bone tumors. Clinical, radiologic and pathologic correlations. Lea and Febiger, Philadelphia pp 1235–1267
Mirra J (1989b) Aneurysmal bone cyst. In: Mirra J, Picci P, Gold R (eds) Bone tumors. Clinical, radiologic and pathologic correlations. Lea and Febiger, Philadelphia, pp 1267–1309
Mirra J, Bernard G, Bullough P et al. (1978) Cementum-like bone production in solitary bone cysts (so-called “cementoma” of long bones). Report of three cases. Electron microscopic observations supporting a synovial origin to the simple bone cyst. Clin Orthop Relat Res 135:295–307
Mohit A, Eskridge J, Ellenbogen R et al. (2004) Aneurysmal bone cyst of the atlas: successful treatment through selective arterial embolization: case report. Neurosurgery 55:1001–1005
Moore T, King A, Travis R et al. (1989) Post-traumatic cysts and cyst-like lesions of bone. Skeletal Radiol 18:93–97
Murphey M, Jaovisidha S, Temple T et al. (2003) Telangiectatic osteosarcoma:radiologic–pathologic correlation. Radiology 229:545–553
Nakano H, Itoh T, Katoh Y et al. (2001) Intraosseous ganglion of the first metacarpal bone. Skeletal Radiol 30:596–599
Namazi H (2008) Practice pearl: a novel use of Botulinum toxin for unicameral bone cyst ablation. Ann Surg Oncol 15:657–658
Neer C, Francis K, Johnston A et al. (1973) Current concepts on the treatment of solitary unicameral bone cyst. Clin Orthop 97:40–51
O’Donnell P, Saifuddin S (2004) The prevalence and diagnostic significance of fluid-fluid levels in focal lesions of bone. Clin Radiol 33:330–336
Oda Y, Tsuneyoshi M, Shinohara N (1992) “Solid” variant of aneurysmal bone cyst (extragnathic giant cell reparative granuloma) in the axial skeleton and long bones. A study of its morphologic spectrum and distinction from allied giant cell lesions. Cancer 70:2642–2649
Oliveira A, Perez-Atayde A, Inwards C et al. (2004) USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 165:1773–1780
Ozaki T, Halm H, Hillman A et al. (1999) Aneurysmal bone cysts of the spine. Arch Orthop Trauma Surg 119:159–162
Pablos J, Valdes J, Gavilan F (1998) Bilateral lunate intraosseous ganglia. Skeletal Radiol 27:708–710
Panoutsakopoulos G, Pandis N, Kyriazoglu I et al. (1999) Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. Genes Chromosomes Cancer 26:265–266
Parman L, Murphey M (2000) Alphabet soup: cystic lesions of bone. Semin Musculoskelet Radiol 4:89–101
Phemister D, Gordon J (1926) The etiology of solitary bone cyst. J Am Med Assoc 87:1429–1433
Pommer G (1920) Zur Kenntnis der progressiven Hämatom- und Phlegmasieveränderungen der Röhrenknochen auf Grund der mikroskopischen Befunde im neuen Knochenzystenfalle. H. v. Haberers. Arch Orthop Unfallchir 17:17–69
Ratcliffe P, Grimer R (1993) Aneurysmal bone cyst arising after tibial fracture. A case report. J Bone Joint Surg [Am] 75A:1225–1227
Richkind K, Mortimer E, Mowery-Rushton P et al. (2002) Translocation (16;20)(p11.2;q13): sole cytogenetic abnormality in a unicameral bone cyst. Cancer Genet Cytogenet 137:153–155
Roach R, Cassar-Pullicino V, Summers B (2002) Paediatric post-traumatic cortical defects of the distal radius. Pediatr Radiol 32:333–339
Roposch A, Saraph V, Linhart W (2000) Flexible intramedullary nailing for the treatment of unicameral bone cysts in long bones. J Bone Joint Surg [Am] 82-A:1447–1453
Roposch A, Saraph V, Linhart W (2004) Treatment of femoral neck and trochanteric simple bone cysts. Arch Orthop Trauma Surg 124:437–442
Sanerkin N (1979) Old fibrin coagula and their ossification in simple bone cysts. J Bone Joint Surg [Br] 61-B:194–199
Scaglietti O, Marchetti P, Bartolozzi P (1982) Final results obtained in the treatment of bone cysts with methylprednisolone acetate (depo-medrol) and a discussion of the results achieved in other bone lesions. Clin Orthop Relat Res 165:33–42
Schajowicz F, Sainz M, Slullitel J (1979) Juxta-articular bone cysts (intra-osseous ganglia). A clinicopathological study of eighty-eight cases. J Bone Joint Surg [Br] 61-B:107–116
Schlesinger P, Keats S, Ruoff A (1949) Fibrous dysplasia: report of a case. J Bone Joint Surg [Am] 31-A:187–191
Shinozaki T, Arita S, Watanabe H et al. (1996) Simple bone cysts treated by multiple drill-holes: 23 cysts followed 2–10 years. Acta Orthop Scand 67:288–290
Struhl S, Edelson C, Pritzker H et al. (1989) Solitary (unicameral) bone cyst. The fallen-fragment sign revisited. Skeletal Radiol 18:261–265
Stürz H, Witt A (1979) Solitary bone cysts of the ulna. Arch Orthop Trauma Surg 31:105–108
Sullivan R, Meyer J, Dormans J et al. (1999) Diagnosing aneurysmal and unicameral bone cysts with magnetic resonance imaging. Clin Orthop Relat Res 366:186–190
Sundaram M, Totty W, Kyriakos M et al. (2001) Imaging findings in pseudocystic osteosarcoma. Am J Roentgenol 176:783–788
Tam W, Resnick D, Haghighi P et al. (1996) Intraosseous ganglion of the patella. Skeletal Radiol 25:588–591
Tillman B, Dahlin D, Lipscomb P et al. (1968) Aneurysmal bone cyst: an analysis of ninety-five cases. Mayo Clin Proc 43:478–495
Topouchian V, Mazda K, Hamze B et al. (2004) Aneurysmal bone cysts in children: complications of fibrosing agent injection. Radiology 232:522–526
Turker R, Mardjetko S, Lubicky S (1998) Aneurysmal bone cysts of the spine: excision and stabilization. J Pediatr Orthop 18:209–213
Van Dyck P, Vanhoenacker P, Vogel J et al. (2006) Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol 16:2644–2651
Vayego S, de Conti O, Varella-Garcia M (1996) Complex cytogenetic rearrangement in a case of unicameral bone cyst. Cancer Genet Cytogenet 86:46–49
Vergel de Dios A, Bond J, Shives T et al. (1992) Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer 69:2921–2931
Violas P, Salmeron F, Chapuis M et al. (2004) Simple bone cysts of the proximal humerus complicated with growth arrest. Acta Orthop Belg 70:166–170
Wada R, Lambert R (2005) Deposition of intraosseous fat in a degenerating simple bone cyst. Skeletal Radiol 34:415–418
Williams H, Davies AM, Allen G et al. (2004) Imaging features of intraosseous ganglia: a report of 45 cases. Eur Radiol 14:1761–1769
Woertler K, Blasius S, Hillmann A et al. (2000) MR morphology of primary aneurysmal bone cysts: a retrospective analysis of 38 cases. Rofo 172:591–596
Yamaguchi T, Dorfman H (2001) Giant cell reparative granuloma. A comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 9:189–200
Zehetgruber H, Bittner B, Gruber D et al. (2005) Prevalence of aneurysmal and solitary bone cysts in young patients. Clin Orthop Relant Res 439:136–143
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O’Donnell, P. (2009). Cystic Lesions of Bone. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_24
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