Skip to main content
SpringerLink
Log in

Hematopoietic Tumors

  • Chapter
Imaging of Bone Tumors and Tumor-Like Lesions

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Key Points

• There are overlapping features among hematopoietic tumors, including osteopenia, lytic lesions, and marrow infiltration.

• Myelofibrosis typically demonstrates diffuse osteosclerosis and splenomegaly due to extra-medullary hematopoiesis.

• Hematopoietic tumors requiring frequent blood transfusions can lead to hemosiderin deposition and low marrow signal intensity on MRI.

• Myelomatous lesions are usually well-circumscribed lytic lesions, and can demonstrate expansile remodeling of the cortical bone.

• Lymphoma can be radiographically occult and MRI findings are frequently out of proportion to those predicted on radiographs.

• Lymphoma can extensively infiltrate the marrow and extend into the adjacent soft tissues without causing significant cortical destruction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abdelwahab IF, Hoch B, Hermann G, Bianchi S, Klein MJ, Springfield DS (2007) Primary periosteal lymphoma: rare and unusual. Skeletal Radiol 36:335−339

    Article  PubMed  Google Scholar 

  • Agool A, Schot B, Jager P, Vellenga E (2006). 18F-FLT PET in hematologic disorders: a novel technique to analyze the bone marrow compartment. J Nucl Med 47:1592−1598

    PubMed  Google Scholar 

  • Angtuaco EJ, Fassas ABT, Walker R, Sethi R, Barlogie B (2004) Multiple myeloma: clinical review and diagnostic imaging. Radiology 231:11−23

    Article  PubMed  Google Scholar 

  • Bertuna G, Fama P, Lo Nigro L, Russo-Mancuso G, Cataldo A di (2003) Marked osteoporosis and spontaneous vertebral fractures in children: don’t forget, it could be leukemia. Med Pediatr Oncol 41:450−451

    Article  PubMed  Google Scholar 

  • Bredella MA, Steinbach L, Caputo G, Segall G, Hawkins R (2005) Value of FDG PET in the assessment of patients with multiple myeloma. Am J Roentgenol 185:1199−1204

    Google Scholar 

  • Breyer RJ III, Mulligan ME, Smith S, Line BR, Badros AZ (2006) Comparison of imaging with FDG PET/CT with other imaging modalities in myeloma. Skeletal Radiol 2006:632−640

    Article  Google Scholar 

  • Brunning RD, Matutes E, Harris NL et al. (2001a) Acute myeloid leukemia: introduction. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 77−80

    Google Scholar 

  • Brunning RD, Borowitz M, Matutes E et al. (2001b) Precursor B lymphoblastic leukemia/lymphoblastic lymphoma (precursor B-cell acute lymphoblastic leukemia). In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 111−114

    Google Scholar 

  • Chong ST, Beasley HS, Daffner RH (2006) POEMS syndrome: radiographic appearance with MRI correlation. Skeletal Radiol 35:690−695

    Article  PubMed  Google Scholar 

  • Cloran F, Banks KP (2007) Diffuse osteosclerosis with hepatosplenomegaly. Am J Roentgenol 188:S18−S20

    Article  Google Scholar 

  • Dankerl A, Liebiesch P, Glatting G, Friesen C, Blunstein NM, Kocot D et al. (2006) Multiple myeloma: molecular imaging with 11C-methionine PET/CT: initial experience. Radiology 242:498−508

    Article  PubMed  Google Scholar 

  • Durie B (2006) The role of anatomic and functional staging in myeloma: description of Durie/Salmon PLUS staging system. Eur J Cancer 42:1539−1543

    Article  PubMed  Google Scholar 

  • Fritz J, Vogel W, Claussen CD, Wehrmann M, Pereira PL, Horger MS (2007) Generalized intramuscular granulocytic sarcoma mimicking polymyositis. Skeletal Radiol 36:985−989

    Article  PubMed  Google Scholar 

  • Graham TS (2005) The ivory vertebra sign. Radiology 235:614−615

    Article  PubMed  Google Scholar 

  • Greenfield HM, Hunt R, Lee LK, Jowitt SN (2006) B-cell chronic lymphocytic leukaemia with extensive lytic lesions. Eur J Haematol 76:356−357

    Article  PubMed  Google Scholar 

  • Grogan TM, Van Camp B, Kyle RA, Muller-Hermelink HK, Harris NL (2001) Plasma cell neoplasms. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 142−156

    Google Scholar 

  • Henry T, Fonseca R (2007) Genomics and proteomics in multiple myeloma and Waldenström macroglobulinemia. Curr Opin Hematol 14:369−374

    Article  PubMed  Google Scholar 

  • Heyning FH, Kroon HMJA, Hogendoorn PCW, Taminiau AHM, van der Woude H-J (2007) MR imaging characteristics in primary lymphoma of bone with emphasis on non-aggressive appearance. Skeletal Radiol 36:937−944

    Article  PubMed  Google Scholar 

  • Hogler W, Wehl G, van Staa T, Meister B, Klein-Franke A, Kroshofer G (2007) Incidence of skeletal complications during treatment of childhood acute lymphoblastic leukemia: comparison of fracture risk with the general practice research database. Pediatr Blood Cancer 48:21−27

    Article  PubMed  Google Scholar 

  • Hughes C, Patterson K, Murray M (2007) Avascular necrosis of the femoral head in childhood chronic myeloid leukemia. Br J Haematol 139:1

    Article  PubMed  CAS  Google Scholar 

  • Hwang S, Panicek DM (2007) Magnetic resonance imaging of bone marrow in oncology. Part 2. Skeletal Radiol 36:1017−1027

    Article  PubMed  Google Scholar 

  • Jadvar H, Conti PS (2002) Diagnostic utility of FDG PET in multiple myeloma. Skeletal Radiol 31:690−694

    Article  PubMed  Google Scholar 

  • Jaffe ES, Harris NL, Stein H, Varidman JW (eds) (2001) World Health Organization classification of tumours. Pathology and genetics. Tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon

    Google Scholar 

  • Kirsch J, Ilaslan H, Bauer TW, Sundaram M (2006) The incidence of imaging findings, and the distribution of skeletal lymphoma in a consecutive patient population seen over 5 years. Skeletal Radiol 35:590−594

    Article  PubMed  Google Scholar 

  • Kobayashi D, Satsuma S, Kamegaya M et al. (2005) Musculoskeletal conditions of acute leukemia and malignant lymphoma in children. J Pediatr Orthop B 14:156−161

    PubMed  Google Scholar 

  • Krishnan A, Shirkhoda A, Tehranzadeh J, Armin AR, Irwin R, Les K (2003) Primary bone lymphoma: radiographic−MR imaging correlation. RadioGraphics 23:1371−1387

    Article  PubMed  Google Scholar 

  • Linden A, Zankovich R, Theissen P, Diehl V, Schicha H (1989) Malignant lymphoma: bone marrow imaging versus biopsy. Radiology 173:335−339

    PubMed  CAS  Google Scholar 

  • Mahnken AH, Wildberger JE, Gehbauer G et al. (2002) Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography. Am J Roentgenol 178:1429−1436

    CAS  Google Scholar 

  • Matuszewski L, Persigehi T, Wall A et al. (2006) Assessment of bone marrow angiogenesis in patients with acute myeloid leukemia by using contrast-enhanced MR imaging with clinically approved iron oxides: initial experience. Radiology 242:217−224

    Article  PubMed  Google Scholar 

  • Mounasamy V, Berns S, Azouz EM, Giusti V, Knapp DR (2006) Anaplastic large cell lymphoma presenting as an epiphyseal lytic lesion: a case report with clinico-pathologic correlation. Skeletal Radiol 35:619−623

    Article  PubMed  Google Scholar 

  • Muller-Hermelink HK, Catovsky D, Montserrat E, Harris NL (2001) Chronic lymphocytic leukaemia/small lymphocytic lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 127−130

    Google Scholar 

  • Mulligan ME (2007) Myeloma update. Semin Musculoskelet Radiol 11:231−239

    Article  PubMed  Google Scholar 

  • Mulligan ME, Badros AZ (2007) PET/CT and MR imaging in myeloma. Skeletal Radiol 36:5−16

    Article  PubMed  Google Scholar 

  • Mulligan ME, McRae GA, Murphey MD (1999) Imaging features of primary lymphoma of bone. Am J Roentgenol 173:1691−1697

    CAS  Google Scholar 

  • Nanni C, Zamagni E, Cavo M et al. (2007) 11C-choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma. World J Surg Oncol 5:68−75

    Article  PubMed  Google Scholar 

  • Ostrowski M, Inwards C, Strickler JG et al. (1999) Osseous Hodgkin’s disease. Cancer 85:1166−1178

    Article  PubMed  CAS  Google Scholar 

  • Pierre R, Imbert M, Thiele J, Vardiman JW, Brunning RD, Flandrin G (2001) Polycythemia vera. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 32−34

    Google Scholar 

  • Resnick D, Haghighi P (2002) Myeloproliferative disorders. In: Resnick D (ed) Diagnosis of bone and joint disorders, 4th edn. Saunders, Philadelphia

    Google Scholar 

  • Rahmouni A, Montazel JL, Divine M et al. (2003) Bone marrow with diffuse tumor infiltration in patients with lymphoproliferative diseases: dynamic gadolinium enhanced MR imaging. Radiology 229:710−717

    Article  PubMed  Google Scholar 

  • Ruzek KA, Wenger DE (2004) The multiple faces of lymphoma of the musculoskeletal system. Skeletal Radiol 33:1−8

    Article  PubMed  CAS  Google Scholar 

  • Taira AV, Herfkens RJ, Gambhir SS, Quon A (2007) Detection of bone metastases: assessment of integrated FDG PET/CT imaging. Radiology 243:204−211

    Article  PubMed  Google Scholar 

  • Tragiannidis A, Athanassiadou F, Papageorgiou T (2006) Severe skeletal complications in a child with acute lymphoblastic leukemia. Pediatr Hematol Oncol 23:523−525

    Article  PubMed  Google Scholar 

  • Vardiman JW, Pierre R, Thiele J, Imbert M, Brunning RD, Flandrin G (2001). Chronic myelogeneous leukemia. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 20−26

    Google Scholar 

  • Vijay A, Gertz MA (2007) Waldenstrom macroglobulinemia. Blood 109:5096−5103

    Article  PubMed  CAS  Google Scholar 

  • Yasumoto M, Nonomura Y, Yoshimura R et al. (2002) MR detection of iliac bone marrow involvement by malignant lymphoma with various MR sequences including diffusion-weighted echo-planar imaging. Skeletal Radiol 31:263−269

    Article  PubMed  CAS  Google Scholar 

  • Zajick DC Jr, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA (2005) Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology 237:590−596

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Central Florida, 32816, Orlando, FL, USA

    Laura W. Bancroft

  2. Florida Hospital, 601 E. Rollins, 32803, Orlando, FL, USA

    Laura W. Bancroft

  3. College of Medicine, Mayo Clinic, 55901, Rochester, MN, USA

    Laura W. Bancroft

Authors
  1. Laura W. Bancroft
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. MRI Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    A. Mark Davies

  2. Section of Musculoskeletal Radiology, Imaging Institute, Diagnostic Radiology/A21, School of Medicine of Case Western Reserve University, Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Murali Sundaram

  3. Imaging Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    Steven L. J. James

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bancroft, L. (2009). Hematopoietic Tumors. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77984-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77982-7

  • Online ISBN: 978-3-540-77984-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation