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Imaging of Bone Tumors and Tumor-Like Lesions pp 307–319Cite as

Fibrogenic and Fibrohistiocytic Tumors

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Key Points

• Lesions of fibrous origin include those tumors of fibrogenic and fibrohistiocytic origin.

• Tumors of fibrogenic origin are those that produce collagen and demonstrate absence of bone and cartilage formation

• Desmoplastic fibroma and fibrosarcoma make up the fibrogenic tumor category.

• Desmoplastic fibroma is a rare benign tumor often associated with recurrence.

• Desmoplastic fibroma is also one of those rare lytic bone tumors that demonstrate predominantly low signal intensity on T2-weighted MR images, reflecting its collagenous nature.

• Microscopically, differentiation may be difficult between desmoplastic fibroma and a low-grade fibrosarcoma, with the absence of herringbone pattern and pleomorphism being the distinguishing factor.

• Tumors of fibrohistiocytic origin encompass both benign and malignant fibrous histiocytoma.

• Fibrohistiocytic tumors are surrounded in controversy, which is further underscored by the fact that the rare entity of benign fibrous histiocytoma is histologically identical to nonossifying fibroma (NOF), with clinical and radiographic features and location being the distinguishing factors between the two.

• Fibrosarcoma and malignant fibrous histiocytoma (MFH) are rare primary bone tumors with overlapping histologic and radiographic appearance.

• Only a close histological examination may differentiate fibrosarcoma and malignant fibrous histiocytoma.

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Author information

Authors and Affiliations

  1. Department of Radiology/Hb6, The Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Monica Koplas

  2. Section of Musculoskeletal Radiology, Imaging Institute, Diagnostic Radiology/A21, School of Medicine of Case Western Reserve University, Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Murali Sundaram

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  1. Monica Koplas
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  2. Murali Sundaram
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Editor information

Editors and Affiliations

  1. MRI Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    A. Mark Davies

  2. Section of Musculoskeletal Radiology, Imaging Institute, Diagnostic Radiology/A21, School of Medicine of Case Western Reserve University, Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Murali Sundaram

  3. Imaging Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    Steven L. J. James

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Koplas, M., Sundaram, M. (2009). Fibrogenic and Fibrohistiocytic Tumors. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_15

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  • DOI: https://doi.org/10.1007/978-3-540-77984-1_15

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