Abstract
Advances in imaging studies and the growing effectiveness of chemotherapy have enabled musculoskeletal tumor surgeons to narrow their margins and employ limb-salvage surgery as the preferred method for managing bone sarcoma. The reconstructive options available to orthopedic oncologists range from allograft transplantation to endoprosthetic reconstruction to a combination of both. Bone allograft transplantation offers a biologic reconstruction that can restore bone stock and joint kinematics, while sparing the opposing articular surface. This chapter will discuss the limitations, complications, survival rates, and indications for using bone allografts.
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Berrey BH Jr, Lord CF, Gebhardt MC, Mankin HJ (1990) Fractures of allografts: frequency, treatment and end-results. J Bone Joint Surg Am 72:825–833
Capanna R, Donati D, Masetti C, Manfrin M, Panozzo A, Cadossi R, Campanacci M (1994) Effect of electromagnetic fields on patients undergoing massive bone graft following bone tumor resection: a double blind study. Clin Orthop Relat Res 306:213–221
Clohisy DR, Mankin HJ (1994) Osteoarticular allografts for reconstruction after resection of a musculoskeletal tumor in the proximal end of the tibia. J Bone Joint Surg Am 76:549–554
Eckardt JJ, Eilber FR, Rosen G, Mirra JM, Dorey FJ, Ward WG, Kabo JM (1991) Endoprosthetic reconstruction for Stage IIB osteosarcoma. Clin Orthop Relat Res 270:202–213
Eckardt JJ, Matthews JG, Eilber FR (1991) Endoprosthetic reconstruction of the proximal tibia. Orthop Clin North Am 22:149–159
Fox EJ, Hau MA, Gebhardt MC, Hornicek FJ, Tomford WW, Mankin HJ (2002) Long-term followup of proximal femoral allograft. Clin Orthop Relat Res 397:106–113
Hornicek FJ, Gebhardt MC, Tomford WW, Sorger JI, Zavata M, Menzner J, Mankin HJ (2001) Factors affecting nonunion of the allo-graft-host junction. Clin Orthop Relat Res 382:87–99
Lord CF, Gebhardt MC, Tomford WW, Mankin HJ (1988) Infection in bone allografts, incidence, nature, and treatment. J Bone Joint Surg Am 70:369–376
Mankin HJ, Doppelt SH, Sullivan HT, Tomford WW (1982) Osteoarticular and intercalary allograft transplantation in the management of malignant tumors of bone. Cancer 50: 613–630
Mankin HJ, Gebhardt MC, Jennings LC, Springfield DS, Tomford WW (1996) Long-term results of allograft replacement in the management of bone tumors. Clin Orthop Relat Res 324:86–94
Musculo DL, Ayerz MA, Aponte-Tinao LA, Ranalletta M (2006) Use of distal femoral oste-oarticular allografts in limb salvage surgery. Surgical technique. J Bone Joint Surg Am 88[Suppl 1]:305–321
Ortiz-Cruz EJ, Gebhardt MC, Jennings LC, et al (1997) The results of transplantation of intercalary allografts after resection of tumors. A long-term follow-up study. J Bone Joint Surg 79A:97–106
Parrish FF (1973) Allograft replacement of all or part of the end of a long bone following excision of a tumor. J Bone Joint Surg Am 55:1–22
Simon MA, Aschliman MA, Thomas N, Mankin HJ (1986) Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg 68A:1331–1337
Kagan RJ (ed) (1999) Standards for tissue banking. American Association of Tissue Banking, McLean, VA
Thompson RC Jr, Pickvance EA, Garry D (1993) Fractures in large-segment allografts. J Bone Joint Surg Am 75:1663–1673
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Raskin, K.A., Hornicek, F. (2009). Allograft Reconstruction in Malignant Bone Tumors: Indications and Limits. In: Tunn, PU. (eds) Treatment of Bone and Soft Tissue Sarcomas. Recent Results in Cancer Research, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77960-5_5
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DOI: https://doi.org/10.1007/978-3-540-77960-5_5
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