Effect of Sevoflurane on Subdural Intracranial Pressure and Cerebral Haemodynamics During Craniotomy
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Volatile anaesthetics act as cerebral vasodilators with the potential to increase cerebral blood flow, cerebral blood volume and ICP. In experimental studies sevoflurane is a less potent vasodilator than isoflurane and halothane, and sevoflurane has been advocated for neurosurgical anaesthesia. However, concerning the effect of ICP, the results in experimental studies are conflicting. In this chapter we discusses sevoflurane and the dose-related changes in cerebrovascular resistance, cerebral blood flow, subdural ICP and relative CO2 reactivity in patients undergoing craniotomy for cerebral tumour.
KeywordsCerebral Blood Flow Cerebral Autoregulation Sevoflurane Anaesthesia Cerebral Tumour Cerebral Vasodilator
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