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Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery pp 201–210Cite as

Effect of a Propofol Bolus Dose on Subdural Intracranial Pressure and Cerebral Haemodynamics During General Anaesthesia for Craniotomy in Patients with Supratentorial Cerebral Tumours

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Abstract

Like barbiturates, propofol suppresses cerebral blood flow and cerebral metabolic rate of oxygen. As a consequence, a decrease in ICP is also expected. Rapid intraoperative reduction of ICP with thiopental has been demonstrated. In patients with head injury, propofol decreases both ICP and mean arterial blood pressure. Cerebral perfusion pressure, however, decreases as well, making the use of propofol in patients with head injury controversial. In patients subjected to craniotomy for space-occupying lesions in propofol-fentanyl or propofol-remifentanil anaesthesia, the effect of a bolus dose of propofol are poorly studied. In this chapter the effect of a propofol bolus during maintenance of anaesthesia with either propofol-remifentanil or propofol-fentanyl is studied, and differences in cerebral haemodynamic parameters are discussed.

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Authors and Affiliations

  1. Department of Neuroanaesthesia, Aarhus University Hospital, Norrebrogade 44, 8000, Aarhus C, Denmark

    Niels Juul

  2. Hojkolvej 2, 8210, Aarhus V, Denmark

    Georg E. Cold

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  1. Niels Juul
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  2. Georg E. Cold
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Editors and Affiliations

  1. Hojkolvej 2, 8210, Aarhus V, Denmark

    Georg E. Cold

  2. Department of Neuroanaesthesia, Aarhus University Hospital, Norrebrogade 44, 8000, Aarhus C, Denmark

    Niels Juul

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Juul, N., Cold, G. (2008). Effect of a Propofol Bolus Dose on Subdural Intracranial Pressure and Cerebral Haemodynamics During General Anaesthesia for Craniotomy in Patients with Supratentorial Cerebral Tumours. In: Cold, G., Juul, N. (eds) Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77873-8_14

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  • DOI: https://doi.org/10.1007/978-3-540-77873-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77872-1

  • Online ISBN: 978-3-540-77873-8

  • eBook Packages: MedicineMedicine (R0)

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