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Effect of a Propofol Bolus Dose on Subdural Intracranial Pressure and Cerebral Haemodynamics During General Anaesthesia for Craniotomy in Patients with Supratentorial Cerebral Tumours

  • Niels Juul
  • Georg E. Cold
Chapter
  • 820 Downloads

Abstract

Like barbiturates, propofol suppresses cerebral blood flow and cerebral metabolic rate of oxygen. As a consequence, a decrease in ICP is also expected. Rapid intraoperative reduction of ICP with thiopental has been demonstrated. In patients with head injury, propofol decreases both ICP and mean arterial blood pressure. Cerebral perfusion pressure, however, decreases as well, making the use of propofol in patients with head injury controversial. In patients subjected to craniotomy for space-occupying lesions in propofol-fentanyl or propofol-remifentanil anaesthesia, the effect of a bolus dose of propofol are poorly studied. In this chapter the effect of a propofol bolus during maintenance of anaesthesia with either propofol-remifentanil or propofol-fentanyl is studied, and differences in cerebral haemodynamic parameters are discussed.

Keywords

Cerebral Blood Flow Bolus Dose Cerebral Autoregulation Cerebral Blood Flow Velocity Cerebral Haemodynamics 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Niels Juul
    • 1
  • Georg E. Cold
    • 2
  1. 1.Department of NeuroanaesthesiaAarhus University HospitalAarhus CDenmark
  2. 2.Aarhus VDenmark

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