Effect of Dihydroergotamine on Subdural Intracranial Pressure and Cerebral Haemodynamics

  • Helle Bundgaard
  • Georg E. Cold


Dihydroergotamine (DHE) acts as a non-competitive agonist at vascular 5-hydroxytryptamine receptors. Experimental studies indicate that DHE is a constrictor of the venous capacitance vessels and, in in vitro studies, DHE induces concentration-dependent contraction in human cerebral arteries and veins. Theoretically, DHE is more effective in the treatment of increased ICP than hyperventilation and is less dangerous because it predominantly acts on the cerebral venous pool, which contains a larger blood volume than the arterial pool. In this chapter DHE and the results of a study dealing with the effect of DHE on arterial blood pressure, subdural ICP, cerebral perfusion pressure, cerebral blood flow and the cerebral metabolism in patients subjected to craniotomy for supratentorial brain tumours is discussed.


Cerebral Blood Flow Cerebral Autoregulation Cerebral Metabolism Cerebral Haemodynamics Cerebral Blood Flow Autoregulation 
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© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Helle Bundgaard
    • 1
  • Georg E. Cold
    • 2
  1. 1.Department of NeuroanaesthesiaAarhus University HospitalAarhus CDenmark
  2. 2.Aarhus VDenmark

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