Effect of Indomethacin on Subdural Intracranial Pressure and Cerebral Haemodynamics

  • Mads Rasmussen
  • Georg E. Cold


Treatment options for increased ICP during craniotomy include hyperventilation, bolus injection of barbiturate or other hypnotic agents, mannitol administration and head elevation. However, these interventions are not consistently successful. Indomethacin acts as a potent cerebral vasoconstrictor and decreases cerebral blood flow and ICP without affecting cerebral oxygen consumption. Previous studies in patients with severe head injury suggested that indomethacin may be effective in lowering high ICP resistant to the traditional methods of managing elevated ICP. Administration of indomethacin may be an alternative option for managing increased ICP in patients undergoing craniotomy. In this chapter two studies concerning indomethacin are presented. The first study includes the effect of perioperative indomethacin on subdural ICP, cerebral blood flow and cerebral metabolic rate of oxygen in patients subjected to craniotomy for cerebral tumour. The second study is a randomized study where we investigated the effect of indomethacin on ICP and cerebral haemodynamics in patients undergoing supratentorial craniotomy.


Cerebral Blood Flow Dura Mater Intracranial Hypertension Severe Head Injury Bone Flap 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Mads Rasmussen
    • 1
  • Georg E. Cold
    • 2
  1. 1.Department of NeuroanaesthesiaAarhus University HospitalAarhus CDenmark
  2. 2.Aarhus VDenmark

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