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Scaffold Structure and Fabrication

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Fundamentals of Tissue Engineering and Regenerative Medicine

Abstract

Whereas the properties of a material’s surface directly influence single cell behaviour, the three-dimensional scaffold structure plays a critical role in the orchestration of tissue formation both in vitro and in vivo. Whereas the microstructure of a material refers to the material at the nanoscale or microscale level (mainly used to characterise material surfaces), scaffold architecture defines the structure of the material in space at a tissue-length scale. Scaffolds not only provide the structural basis for cells to form a three-dimensional tissue-like construct in vitro, but they also determine the features of mass transport (diffusion and convection). The scaffold architecture affects both single-cell parameters (e.g. cell viability, cell migration, cell differentiation) and the composition of the generated tissue substitute.

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Author information

Authors and Affiliations

  1. Biomineralisation and Tissue Engineering Group, Department of Experimental Maxillofacial Surgery, University of Münster, Waldeyerstr. 30, 48149, Münster, Germany

    Hans Peter Wiesmann

  2. Clinic for Cranio-, Maxillofacial Surgery, University of Münster, Waldeyerstr. 30, 48149, Münster, Germany

    Lydia Lammers

Authors
  1. Hans Peter Wiesmann
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  2. Lydia Lammers
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Editor information

Editors and Affiliations

  1. Clinic for Maxillofacial and Plastic Facial Surgery, Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany

    Ulrich Meyer  & Jörg Handschel  & 

  2. Department of Experimental Maxillofacial Surgery, Biomineralisation and Tissue Engineering Group, University of Münster, Waldeyerstraße 30, 48149, Münster, Germany

    Hans Peter Wiesmann

  3. Department of Internal Medicine – Cardiology, University Hospital Marburg, Baldingerstraße 1, 35033, Marburg, Germany

    Thomas Meyer

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Wiesmann, H., Lammers, L. (2009). Scaffold Structure and Fabrication. In: Meyer, U., Handschel, J., Wiesmann, H., Meyer, T. (eds) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77755-7_39

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  • DOI: https://doi.org/10.1007/978-3-540-77755-7_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77754-0

  • Online ISBN: 978-3-540-77755-7

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