Abstract
Adult articular cartilage has a limited capacity for repair and cartilage defects often progress to osteoarthritis [7, 8]. The potential to repair hyaline cartilage is limited due to poor vascularisation, reduced migration and mitogenic characteristics of chondrocytes. In 1987 autologous chondrocytes transplantation was pioneered by Peterson and Brittberg to treat cartilage defects mainly in the knee joint. Peterson und Brittberg (1994) introduced a method where in vitro-propagated chondrocytes in suspension were transplanted under a periosteal flap to treat cartilage defects of human (ACT) [20, 21]. During the following years numerous in vitro and in vivo studies were performed to obtain insight into characteristics, function and behaviour of chondrocytes as well as to improve operational techniques, standardize clinical assessment and rehabilitation procedure. The first step for the operational improvement of the mentioned first generation of ACT was done by replacing the periosteal flap by a collagen membrane to cover the cartilage defect [23].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderer U, Libera J: In vitro engineering of human autogenous cartilage. J Bone Miner Res 17:1420–29, 2002
Andereya S, Maus U, Gavenis K, Gravius S, Stanzel S, Müller-Rath R, Miltner O, Mumme T, Schneider U: Treatment of patellofemoral cartilage defects utilizing a 3D collagen gel: two-year clinical results. Z Orthop Unfall 45(2):139–45, 2007
Bachmann G, Basad E, Lommel D, Steinmeyer J: MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture. Radiologe 44(8):773–82, 2004
Behrens P, Ehlers EM, Köchermann KU, Rohwedel J, Russlies M, Plötz W: New therapy procedure for localized cartilage defects. Encouraging results with autologous chondrocyte implantation. MMW Fortschr Med 141(45):49–51, 1999
Behrens P: Matrixgekoppelte Mikrofrakturierung. Ein neues Konzept zur Knorpeldefektbehandlung. Arthroskopie 8:193–197, 2005
Behrens P, Bitter T, Kurz B, Russlies M: Matrix-associated autologous chondrocyte Transplantation/implantation (MACT/MACI)—5-year follow-up. Knee 13(3):194–2 Epub, 2006
Davies-Tuck ML, Wluka AE, Wang Y, Teichtahl AJ, Jones G, Ding C, Cicuttini FM: The natural history of cartilage defects in people with knee osteoarthritis. Osteoarthritis Cartilage, 2007
Davis MA, Ettinger WH, Neuhaus JM, Cho SA, Hauck WW: The association of knee injury and obesity with unilateral and bilateral osteoarthritis of the knee. Am J Epidemiol 130:278–288, 1989
Dorotka R, Kotz R, Tratting S, Nehrer S: Mid-term results of autologous chondrocyte transplantation in knee and ankle. A one- to six-year follow-up study. Z Rheumatol 63(5):385–92, 2004
Flohe S, Schulz M: Prospektiver Vergleich zweier Matrix-gekoppelter Chondrozyten. Transplantationsverfahren zur Behandlung von Knorpelschäden im Kniegelenk. Ger Med Sci GM07dkou002, 2007
Hendriks J, de Bruijn E, Schotel R, van Blitterswijk CA, Riesle J: Cellular synergy for 1 step cartilage repair. Oral presentation at the ICRS, Warsaw, 2007
Hunziker EB: Biologic repair of articular cartilage. Defect models in experimental animals and matrix requirements. Clin Orthop 367:S135–S46, 1999
Kramer J, Böhrnsen F, Lindner U, Behrens P, Schlenke P, Rohwedel J: In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci 63(5):616–26, 2006
Libera J, Luethi U, Alasevic OJ: Autologous matrix-induced engineered cartilage transplantation. In: Zanasi S, Brittberg M, Marcacci M; Basic Science, clinical repair and reconstruction of articular cartilage defects: current status and prospects, Volume 1, p.591–600, Italy, 2006
Lu Y, Dhanaraj S, Wang Z, Bradley DM, Bowman SM, Cole BJ, Binette F: Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair. J Orthop Res 24(6):1261–70, 2006
Mainil-Varlet P, Riese F, Grogan S, Mueller W, Saager C, Jakob RP: Articular cartilage repair using a tissue engineered cartilage-like implant: an animal study. Osteoarthritis Cartilage 9:6–15, 2001
Meyer U, Runte C, Dirksen D, Stamm T, Fillies T, Joos U, Wiesmann HP: Image based biomimetric approach to design and fabrication of tissue engineered bone. Comp Assisted Radiol Surg 123:726–32, 2003
Nehrer S, Dorotka R, Schatz K, Bindreiter U, Kotz R: Klinische Ergebnisse nach matrixassitierter Knorpelzelltransplantation mit Hyaluronat Vlies. Ger Med Sci GM04dgu0558, 2004
Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. 9(2):R41, 2007
Peterson L, Minas T, Brittberg M, Nilsson A, Sjögren-Jansson E, Lindahl A: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374:212–34, 2000
Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der Bauwhede J, Vandenneucker H, Yang KG, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP: Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36(2):235–46, 2008
Schmidt A, Johann K, Kunz M: Erste klinische Ergebnisse nach matrixgekoppelter autologer Chondrozytentransplantation am Kniegelenk. 35th congress of the DGRh and 21st annual conference of the ARO, Hamburg, 2007
Steinwachs M, Kreuz PC: Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up. Arthroscopy 23(4):381–7, 2007
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Libera, J. et al. (2009). Cartilage Engineering. In: Meyer, U., Handschel, J., Wiesmann, H., Meyer, T. (eds) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77755-7_18
Download citation
DOI: https://doi.org/10.1007/978-3-540-77755-7_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-77754-0
Online ISBN: 978-3-540-77755-7
eBook Packages: MedicineMedicine (R0)