Abstract
Adult articular cartilage has a limited capacity for repair and cartilage defects often progress to osteoarthritis [7, 8]. The potential to repair hyaline cartilage is limited due to poor vascularisation, reduced migration and mitogenic characteristics of chondrocytes. In 1987 autologous chondrocytes transplantation was pioneered by Peterson and Brittberg to treat cartilage defects mainly in the knee joint. Peterson und Brittberg (1994) introduced a method where in vitro-propagated chondrocytes in suspension were transplanted under a periosteal flap to treat cartilage defects of human (ACT) [20, 21]. During the following years numerous in vitro and in vivo studies were performed to obtain insight into characteristics, function and behaviour of chondrocytes as well as to improve operational techniques, standardize clinical assessment and rehabilitation procedure. The first step for the operational improvement of the mentioned first generation of ACT was done by replacing the periosteal flap by a collagen membrane to cover the cartilage defect [23].
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Libera, J. et al. (2009). Cartilage Engineering. In: Meyer, U., Handschel, J., Wiesmann, H., Meyer, T. (eds) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77755-7_18
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DOI: https://doi.org/10.1007/978-3-540-77755-7_18
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