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Stem Cell Plasticity: Validation Versus Valedictory

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Fundamentals of Tissue Engineering and Regenerative Medicine

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Abstract

The field of stem cell plasticity, by which most commentators and investigators mean plasticity of adult stem cells, was opened to great fanfare with the publication of three papers in Science in the last 2 years of the prior millennium. This trio, taken together, was trumpeted by Science as the “Breakthrough of the Year” for 1999 and showed that stem cells deriving from one organ were not only not restricted to producing cells of that organ (so, e.g., marrow-derived cells could become skeletal muscle) but were also not restricted to their embryonic germ layer of origin (neural stem cells produced blood and marrowderived stem cells produced liver) [1–3].

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Author information

Authors and Affiliations

  1. Division of Digestive Diseases, Beth Israel Medical Center, First Avenue at 16th Street, 10003, New York, NY, USA

    Neil David Theise

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  1. Neil David Theise
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Editor information

Editors and Affiliations

  1. Clinic for Maxillofacial and Plastic Facial Surgery, Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany

    Ulrich Meyer  & Jörg Handschel  & 

  2. Department of Experimental Maxillofacial Surgery, Biomineralisation and Tissue Engineering Group, University of Münster, Waldeyerstraße 30, 48149, Münster, Germany

    Hans Peter Wiesmann

  3. Department of Internal Medicine – Cardiology, University Hospital Marburg, Baldingerstraße 1, 35033, Marburg, Germany

    Thomas Meyer

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Theise, N. (2009). Stem Cell Plasticity: Validation Versus Valedictory. In: Meyer, U., Handschel, J., Wiesmann, H., Meyer, T. (eds) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77755-7_16

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  • DOI: https://doi.org/10.1007/978-3-540-77755-7_16

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