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Optical Frequency Domain Imaging

  • B. E. Bouma
  • G. J. Tearney
  • B. J. Vakoc
  • S. H. Yun
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

In most OCT systems, one-dimensional (depth) ranging is provided by lowcoherence interferometry [2, 3] in which the optical path length difference between the interferometer reference and sample arms is scanned linearly in time. This embodiment of OCT, referred to as “time-domain OCT,” has demonstrated promising results for minimally invasive, early detection of disease. The relatively slow imaging speed (approximately 2 kHz A-line rate) of time-domain OCT systems, however, has precluded its use for screening large tissue volumes, which is required for a wide variety of medical applications. Imaging speed has a fundamental significance because of its relationship to detection sensitivity (minimum detectable reflectivity). As the A-line rate increases, the detection bandwidth should be increased proportionally, and therefore the sensitivity drops. The sensitivity of state-of-the-art time-domain OCT systems that operate at 2-kHz, ranges between −105 and −110 dB. Most biomedical applications require this level of sensitivity for sufficient depth of penetration and cannot tolerate a reduction in sensitivity to achieve a higher frame rate. Although increasing the optical power would, in principle, improve the sensitivity, available sources and maximum permissible exposure levels of tissue represent significant practical limitations.

Keywords

Discrete Fourier Transform Sample Signal Axial Resolution Spectral Envelope Relative Intensity Noise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, R. Yelin, W.Y. Oh, A. Desjardins, R.C. Chan, D. Yelin, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, B.E. Bouma, Nat. Med. 12, 1429 (2006)CrossRefPubMedGoogle Scholar
  2. 2.
    K. Takada, I. Yokohama, K. Chida, J. Noda, Appl. Opt. 26, 1603 (1987)CrossRefPubMedGoogle Scholar
  3. 3.
    R.C. Youngquist, S. Carr, D.E.N. Davies, Opt. Lett. 12, 158 (1987)CrossRefPubMedGoogle Scholar
  4. 4.
    A.F. Fercher, C.K. Hitzenberger, G. Kamp, S.Y. El-Zaiat, Opt. Commun. 117, 43(1995)CrossRefGoogle Scholar
  5. 5.
    G. Hausler, M.W. Linduer, J. Biomed. Opt. 3, 21 (1998)CrossRefGoogle Scholar
  6. 6.
    M.A. Choma, M.V. Sarunic, Y. Changhuei, J.A. Izatt, Opt. Express 11 (2003)Google Scholar
  7. 7.
    J.F. de Boer, B. Cense, B.H. Park, M.C. Pierce, G.J. Tearney, B.E. Bouma, Opt. Lett. 28, 2067 (2003)CrossRefPubMedGoogle Scholar
  8. 8.
    R. Leitgeb, C.K. Hitzenberger, A.F. Fercher, Opt. Express 11 (2003)Google Scholar
  9. 9.
    E. Brinkmeyer, R. Ulrich, Electron. Lett. 26, 413 (1990)CrossRefGoogle Scholar
  10. 10.
    S.R. Chinn, E.A. Swanson, J.G. Fujimoto, Opt. Lett. 22, 340 (1997)CrossRefPubMedGoogle Scholar
  11. 11.
    B. Golubovic, B.E. Bouma, G.J. Tearney, J.G. Fujimoto, Opt. Lett. 22, 1704 (1997)CrossRefPubMedGoogle Scholar
  12. 12.
    F. Lexer, C.K. Hitzenberger, A.F. Fercher, M. Kulhavy, Appl. Opt. 36, 6548 (1997)CrossRefPubMedGoogle Scholar
  13. 13.
    W.V. Sorin, D.M. Baney, IEEE Photon. Technol. Lett. 4, 1404 (1992)CrossRefGoogle Scholar
  14. 14.
    S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, B.E. Bouma, Opt. Express 11,2953 (2003)CrossRefPubMedGoogle Scholar
  15. 15.
    K. Takada, Y. Kenichi, M. Kobayashi, J. Noda, Appl. Phys. Lett. 59, 143 (1991)CrossRefGoogle Scholar
  16. 16.
    M. Wojtkowski, A. Kowalczyk, R. Leitgeb, A.F. Fercher, Opt. Lett. 27, 1415 (2002)CrossRefPubMedGoogle Scholar
  17. 17.
    X.Q. Zhou, K. Iiyama, K. Hayashi, IEEE Photon. Technol. Lett. 8, 248 (1996)CrossRefGoogle Scholar
  18. 18.
    M.A. Choma, C. Yang, J.A. Izatt, Opt. Lett. 28, 2162 (2003)CrossRefPubMedGoogle Scholar
  19. 19.
    H. Barfuss, E. Brinkmeyer, J. Lightwave Technol. 7, 3 (1989)CrossRefGoogle Scholar
  20. 20.
    S.H. Yun, G.J. Tearney, J.F. de Boer, B.E. Bouma, Opt. Express 12, 4822 (2004)CrossRefPubMedGoogle Scholar
  21. 21.
    C. Dorrer, N. Belabas, J.P. Likforman, M. Joffre, J. Opt. Soc. Am. B 17, 1795 (2000)CrossRefGoogle Scholar
  22. 22.
    Alfidi R.J., MacIntyre W.J., Haaga R. Am. J. Radiol. 127, 11 (1976)Google Scholar
  23. 23.
    S.K. Nadkarni, D.R. Boughner, M. Drangova, A. Fenster, Ultrasound Med. Biol. 27,211(2001)CrossRefPubMedGoogle Scholar
  24. 24.
    M.L. Wood, R.M. Henkelman, NMR image artifact from periodic motion. Med. Phys. 12, 143 (1985)Google Scholar
  25. 25.
    S.H. Yun, G.J. Tearney, J.F. de Boer, B.E. Bouma, Opt. Express 12, 2979 (2004)Google Scholar
  26. 26.
    J.M. Schmitt, S.H. Xiang, K.M. Yung, J. Biomed. Opt. 4, 95 (1999)CrossRefGoogle Scholar
  27. 27.
    Y.H. Zhao, Z.P. Chen, C. Saxer, S.H. Xiang, J.F. de Boer, J.S. Nelson, Opt. Lett. 25, 114 (2000)CrossRefPubMedGoogle Scholar
  28. 28.
    B.R. White, M.C. Pierce, N. Nassif, B. Cense, B.H. Park, G.J. Tearney, B.E. Bouma, T.C. Chen, J.F. de Boer, Opt. Express 11, 3490 (2003)PubMedCrossRefGoogle Scholar
  29. 29.
    B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, J.F. de Boer, Opt. Express 13, 3931 (2005)CrossRefPubMedGoogle Scholar
  30. 30.
    S. Yazdanfar, C. Yang, M.V. Sarunic, J.A. Izatt, Opt. Express 13, 410 (2005)CrossRefPubMedGoogle Scholar
  31. 31.
    S. Yun, C. Boudoux, G. Tearney, B. Bouma, Opt. Lett. 28, 1981 (2003)CrossRefPubMedGoogle Scholar
  32. 32.
    M.V. Sarunic, M.A. Choma, C.H. Yang, J.A. Izatt, Opt. Express 13, 957 (2005)CrossRefPubMedGoogle Scholar
  33. 33.
    M.C. Pierce, B.H. Park, B. Cense, J.F. de Boer, Opt. Lett. 27, 1534 (2002)CrossRefPubMedGoogle Scholar
  34. 34.
    S.H. Yun, G.J. Tearney, J.F. de Boer, B.E. Bouma, Opt. Express 12, 5614 (2004)CrossRefPubMedGoogle Scholar
  35. 35.
    G.J. Tearney, I.K. Jang, B.E. Bouma, J. Biomed. Opt. 11, 021002 (2006)CrossRefPubMedGoogle Scholar
  36. 36.
    H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.-K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.-H. Kang, E.F. Halpern, G.J. Tearney, Circulation 106, 1640 (2002)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • B. E. Bouma
  • G. J. Tearney
  • B. J. Vakoc
  • S. H. Yun

There are no affiliations available

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