Fourier domain optical coherence tomography (FdOCT) [1, 2] provides significant improvement in detection sensitivity and imaging speed as compared to time domain OCT [3–5]. The delay and magnitude of backscattered or back-reflected light detected by any OCT system carries information about the axial structure of semi-transparent objects. FdOCT devices reconstruct the sample structure by spectral analysis of the spectral interference fringe signal. FdOCT detection can be performed in two ways: Spectral OCT using a spectrometer with an array or matrix of photodetectors (CCD, CMOS, or photodiode arrays) [1, 6–8] or swept source OCT using a tunable laser source [1, 9–16]. Spectral OCT has demonstrated superior imaging speed as compared to time domain OCT when applied to ophthalmic imaging in the anterior eye segment and the retina [7, 8, 17–23]. Spectral OCT and Swept Source OCT are also promising for three-dimensional ultra high resolution imaging [7, 17, 20, 21, 24]. An advantage of FdOCT is the possibility of having direct access to the spectral fringe pattern, enabling a wide range of novel applications such as tissue absorption measurement [25] and tissue contrast enhancement [26]. Additionally, the high speed combined with simultaneous registration of all spectral components (spectral OCT) provides stable phase information [27, 28]. The availability of signal phase information due to coherent signal detection is one of the most important advantages of OCT. It allows pushing the resolution limits down to the nanometer range and extending the capabilities of FdOCT from the purely structural toward a potential functional imaging modality with high temporal resolution [29–31].
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References
A.F. Fercher et al., Opt. Commun. 117(1-2), 43 (1995)
G. Hausler, M.W. Linduer, J. Biomed. Opt. 3(1), 21 (1998)
R. Leitgeb, C.K. Hitzenberger, A.F. Fercher, Opt. Express 11(8), 889 (2003)
J.F. de Boer et al., Opt. Lett. 28(21), 2067 (2003)
M.A. Choma et al., Opt. Express 11(18), 2183 (2003)
M. Wojtkowski et al., J. Biomed. Opt. 7(3), 457 (2002)
N.A. Nassif et al., Opt. Express 12(3), 367 (2004)
R.A. Leitgeb et al., Opt. Express 12(10), 2156 (2004)
F. Lexer et al., Appl. Opt. 36(25), 6548 (1997)
S.H. Yun et al., Opt. Express 11(26), 3598 (2003)
S.H. Yun et al., Opt. Lett. 28(20), 1981 (2003)
S.H. Yun et al. IEEE Photon. Technol. Lett. 16(1), 293 (2004)
R. Huber et al., Opt. Express 13(9), 3513 (2005)
R. Huber et al., Opt. Express 13(26), 10523 (2006)
S.R. Chinn, E.A. Swanson, J.G. Fujimoto, Opt. Lett., 22(5), 340 (1997)
M.A. Choma, K. Hsu, J.A. Izatt, J. Biomed. Opt. 10(4), 44009 (2005)
M. Wojtkowski et al., Am. J. Ophthalmol., 138(3), 412 (2004)
M. Wojtkowski et al., Opt. Lett. 28(19), 1745 (2003)
M. Wojtkowski et al., Opt. Express 12(11), 2404 (2004)
M. Wojtkowski et al., Ophthalmology 112(10), 1734 (2005)
U. Schmidt-Erfurth et al., Invest. Ophthalmol. Vis. Sci. 46(9), 3393 (2005)
B.J. Kaluzny et al., Ophthalmic. Physiol. Opt. 26(2), 127 (2006)
R.J. Zawadzki et al., Opt. Express 13(21), 8532 (2005)
Y. Yasuno et al. Opt. Express, 13(26), 10652 (2005)
R. Leitgeb et al., Opt. Lett. 25(11), 820 (2000)
R.A. Leitgeb et al., Invest. Ophthalmol. Vis. Sci. 46, (2005)
R. Leitgeb et al., SPIE Proc. 4619, 16 (2002)
M.A. Choma, et al., Opt. Lett. 30(10), 1162 (2005)
R.A. Leitgeb et al., Opt. Express 11(23), 3116 (2003)
R.A. Leitgeb et al., Opt. Lett. 29(2), 171 (2004)
B.R. White et al. Opt. Express 11(25), 3490 (2003)
R.A. Leitgeb et al., Opt. Lett., 28(22), 2201 (2003)
M. Wojtkowski et al., Opt. Lett., 27(16), 1415 (2002)
P. Targowski et al., Opt. Commun. 249(1-3), 357 (2005)
P. Targowski, Opt. Commun. 229(1-6), 79 (2004)
A.M. Davis, M.A. Choma, J.A. Izatt, J. Biomed. Opt. 10(6), 64005 (2005)
J. Zhang, J.S. Nelson, Z.P. Chen, Opt. Lett. 30(2), 147 (2005)
J. Zhang et al., Opt. Express 12(24), 6033 (2004)
S.H. Yun et al., Opt. Express, 12(20), 4822 (2004)
E. Gotzinger et al., Opt. Express 13(2), 583 (2005)
Y. Yasuno et al., Opt. Express 12(25), 6184 (2004)
Y. Yasuno et al., in: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX (SPIE, San Jose, CA, 2005)
A.H. Bachmann, R.A. Leitgeb, T. Lasser, Opt. Express 14(4), 1487 (2006)
V. Westphal, A.M. Rollins, S. Radhakrishnan, Opt. Express 10(9), (2002)
R.J. Zawadzki et al., Invest. Ophthalmol. Vis. Sci. 44, U141 (2003)
J.W. Goodman, Statistical Optics (Wiley, New York, 1995)
J. Schmit, K. Creath, Appl. Opt. 34(19), 3610 (1995)
S.H. Yun et al., Opt. Express 12(13), 2977 (2004)
A.H. Bachmann et al., Opt. Express 15(2), 408 (2006)
S.H. Yun et al., Opt. Express 12(23), 5614 (2004)
J.W. You et al., Opt. Express, 14(15), 6739 (2006)
R. Leitgeb et al., in: Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI (SPIE, San Jose, CA, 2002).
R.K. Ahrenkie, J. Opt. Soc. Am. 61(12), 1651 (1971)
K.F. Palmer, M.Z. Williams, B.A. Budde, Appl. Opt. 37(13), 2660 (1998)
D.J. Faber et al., Phys. Rev. Lett. 93(2), (2004)
R.A. Leitgeb et al., Opt. Lett. 29(2), 171 (2004)
B.H. Park et al., Opt. Express 13(11), 3931 (2005)
J. Zhang, Z.P. Chen, Opt. Express 13(19), 7449 (2005)
J. Flammer et al., Prog. Retin. Eye Res. 21(4), 359 (2002)
L. Schmetterer, M. Wolzt, Diabetologia 42(4), 387 (1999)
E. Friedman, Am. J. Ophthalmol. 124(5), 677 (1997)
A. Szkulmowska et al., J. Phys. D 38(15), 2606 (2005)
A.F. Fercher et al., in: Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II, 1999: SPIE.
K. Creath, Prog. Opt. 26, 349 (1988)
J. Oh, B. Kim, in: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX (SPIE, San Jose, 2005).
M.V. Sarunic et al., Opt. Express 13(3), 957 (2005)
M.A. Choma, C. Yang, J.A. Izatt, Opt. Lett. 28(22), 2162 (2003)
Y. Yasuno, S. Makita, T. Endo, G. Aoki, M. Itoh and T. Yatagai, Appl. Opt. 45 (8),1861-1865 (2006)
M. Takeda, H. Ina, and S. Kobayashi, J. Opt. Soc. Am. 72, 156 (1982)
R.K. Wang, Appl. Phys. Lett. 90(5), (2007)
R.A. Leitgeb, R. Michaely, T. Lasser, and S.C. Sekhar, Opt. Lett. 32, 3453-3455 (2007)
B. Baumann, M. Pircher, E. Götzinger, and C.K. Hitzenberger, Opt. Express 15,13375-13387 (2007)
L. An and R.K. Wang, Opt. Lett. 32, 3423-3425 (2007)
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Leitgeb, R.A., Wojtkowski, M. (2008). Complex and Coherence Noise Free Fourier Domain Optical Coherence Tomography. In: Drexler, W., Fujimoto, J.G. (eds) Optical Coherence Tomography. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77550-8_6
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