OCT in Laryngology

  • A. B. Terentéva
  • A. V. Shakhov
  • A. V. Maslennikova
  • N. D. Gladkova
  • V. A. Kamensky
  • F. I. Feldchtein
  • N. M. Shakhova
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Issues involving the diagnostics and treatment of laryngeal pathologies are currently becoming more and more important from medical and social viewpoints. This is related to a continued increase in the incidence of laryngeal pathologies in general and cancer-related in particular [1].

Using conservative treatment methods combined with modern technologies allows us not only to adequately remove a pathological lesion, but also to preserve the organ functions to the maximum extent [2–4]. In this case, the inadequate diagnostics or staging inevitably increases the risk of continuing growth, recurrence, or metastasis of the tumor. In addition, the adequate diagnostic ideally should not be limited to the initial diagnostics stage, but instead has to be available throughout the treatment process, including intraoperative guidance. The treatment efficacy is significantly dependent upon the quality of the diagnostics, including type, extent, and stage of the pathological process.


Optical Coherence Tomography Vocal Fold Optical Coherence Tomography Image Epithelial Dysplasia Optical Coherence Tomography System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    D.M. Parkin, F. Bray, J. Ferlay, P. Pisani, CA Cancer J. Clin. 55(2), 74 (2005)CrossRefPubMedGoogle Scholar
  2. 2.
    M. Ptok, Laryngo-Rhino-Otologie 47, 766 (1999)Google Scholar
  3. 3.
    M.M. Steven, S.M. Zeitels, Laryngoscope 106, 545 (1996)CrossRefGoogle Scholar
  4. 4.
    S.M. Zeitels, Laryngoscope 105(3 Pt 2), 1 (1995)PubMedGoogle Scholar
  5. 5.
    J. Droppa, Clin. Otolaryngol. 30(6), 345 (1981)Google Scholar
  6. 6.
    W. Lehmann, J. Pampurik, J.P. Guyot, ORL J. Otorhinolaryngol. Relat. Spec. 51(4),206 (1989)PubMedGoogle Scholar
  7. 7.
    D. Ferson, T.L. Chi, Thorac. Surg. Clin. 15(1), 39 (2005)CrossRefPubMedGoogle Scholar
  8. 8.
    Y.D. Heman-Ackah, Curr. Opin. Otolaryngol. Head Neck Surg. 12(6), 549 (2004)CrossRefPubMedGoogle Scholar
  9. 9.
    J.T. Bushberg, The Essential Physics of Medical Imaging, 2nd ed. (Lippincott Williams & Wilkins, Philadelphia, 2002)Google Scholar
  10. 10.
    P. Jecker, R. Schuon, A. Hlawatsch, Ultraschall. Med. 26(4), 312 (2005)CrossRefPubMedGoogle Scholar
  11. 11.
    R.J. Kau, C. Alexiou, H. Stimmer, W. Arnold, ORL J. Otorhinolaryngol. Relat. Spec. 62(4), 199 (2000)PubMedGoogle Scholar
  12. 12.
    J.S. Rubin, S. Lee, J. McGuinness, I. Hore, D. Hill, L. Berger, J. Voice. 18(2), 231 (2004)CrossRefPubMedGoogle Scholar
  13. 13.
    T. Vogl, Differential Diagnosis in Head-and-Neck Imaging (Thieme, Stuttgart, New York, 1998)Google Scholar
  14. 14.
    S.L. Werner, R.A. Jones, C.L. Emerman, Acad. Emerg. Med. 11(12), 1358 (2004)CrossRefPubMedGoogle Scholar
  15. 15.
    C. Arens, B. Eistert, H. Glanz, W. Waas, Eur. Arch. Otolaryngol. 255, 250 (1998)CrossRefGoogle Scholar
  16. 16.
    C. Arens, H. Glanz, Eur. Arch. Otolaryngol. 256, 316 (1999)CrossRefGoogle Scholar
  17. 17.
    C. Arens, T. Dreyer, K. Malzahn, H. Glanz, Otolaryngol. Pol. 58(1), 197 (2004)PubMedGoogle Scholar
  18. 18.
    N. Baletic, Z. Petrovic, I. Pendjer, H. Malicevic, Eur. Arch. Otorhinolaryngol. 261(5),233 (2004)CrossRefPubMedGoogle Scholar
  19. 19.
    M. Csanady, J.G. Kiss, L. Ivan, J. Jori, J. Czigner, Eur. Arch. Otorhinolaryngol. 261(5),262 (2004)CrossRefPubMedGoogle Scholar
  20. 20.
    Z. Palasz, A. Grobelny, E. Pawlik, M. Fraczek, M. Zalesska-Krecicka, A. Klimczak et al., Auris Nasus Larynx. 30(4), 385 (2003)CrossRefPubMedGoogle Scholar
  21. 21.
    M. Mehlmann, C.S. Betz, H. Stepp, S. Arbogast, R. Baumgartner, G. Grevers et al., Lasers Surg. Med. 25(5), 414 (1999)CrossRefPubMedGoogle Scholar
  22. 22.
    M. Hirano, S. Kurita, Histological Structure of the Vocal Fold and Its Normal and Pathologic Variations (College-Hill Press, San Diego, 1986)Google Scholar
  23. 23.
    M. Hirano, S. Kurita, T. Nakashima, The Structure of the Vocal Folds, Vocal Fold Physiology (University of Tokyo Press, Tokyo, 1981)Google Scholar
  24. 24.
    P. Zbaren, M. Becker, H. Lang, Eur. Arch. Otorhinolaryngol. 254(Suppl 1), S117 (1997)CrossRefPubMedGoogle Scholar
  25. 25.
    S.M. Zeitels, Oper. Techniq. Otolaryngol. Head Neck Surg. (Phonosurg) 4, 218 (1993)CrossRefGoogle Scholar
  26. 26.
    J. Brouwer, E.J. Bodar, R. De Bree, J.A. Langendijk, J.A. Castelijns, O.S. Hoekstra et al., Eur. Arch. Otorhinolaryngol. 261(8), 417 (2004)CrossRefPubMedGoogle Scholar
  27. 27.
    A. Welge-Luessen, Laryngo-Rhino-Otologie 75, 611 (1996)CrossRefGoogle Scholar
  28. 28.
    A.M. Sergeev, V.M. Gelikonov, G.V. Gelikonov, F.I. Feldchtein, R.V. Kuranov, N.D. Gladkova et al., Opt. Exp. 1(13), 432 (1997)CrossRefGoogle Scholar
  29. 29.
    N.D. Gladkova, A.V. Shakhov, F.I. Feldchtein, in Handbook of Optical Coherence Tomography, ed. by B.E. Bouma, G.J. Tearney, (Marcel Dekker, New York, Basel, 2002), p. 705-24Google Scholar
  30. 30.
    . N.D. Gladkova, N.M. Shakhova, A.V. Shakhov, G.A. Petrova, I.A. Kuznetzova, F.I. Feldchtein et al., in Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III Proc of SPIE, 1999, p. 86-97Google Scholar
  31. 31.
    . A.V. Shakhov, A.B. Terent’eva, N.D. Gladkovam F.I. Feldchtein, V.M. Gelikonov, G.V. Gelikonov et al., in Lasers in Surgery: Advanced Character-ization, Therapeutics, and Systems IX Proc of SPIE, SPIE, 1998, p. 250-260Google Scholar
  32. 32.
    A.V. Shakhov, A.B. Terentjeva, V.A. Kamensky, L.B. Snopova, V.M. Gelikonov, F.I. Feldchtein et al., J. Surg. Oncol. 77, 253 (2001)CrossRefPubMedGoogle Scholar
  33. 33.
    A.G. Bibas, A.G. Podoleanu, R.G. Cucu, M. Bonmarin, G.M. Dobre, V.M. Ward et al., Clin. Otolaryngol. Allied Sci. 29(6), 713 (2004)CrossRefPubMedGoogle Scholar
  34. 34.
    A.G. Bibas, A.G. Podoleanu, R.G. Cucu, G.M. Dobre, E. Odell, A.B. Boxer et al., Proc. SPIE 5312(1), 190 (2004)CrossRefGoogle Scholar
  35. 35.
    M.C. Pierce, A. Klein, J.A. Burns, M. Shishkov, B.H. Park, G.J. Tearney et al., in Endoscopic Imaging of the Human Vocal Cords Using Polarization-Sensitive Optical Coherence Tomography, ed. by E.B. Kenneth, S.B. Lawrence, T.W.D.R. Werner, W.G. Kenton, H. Henry, K. Abraham, et al., (SPIE, Bellingham, WA, 2005), p. 307-309Google Scholar
  36. 36.
    P.R. Herz, Y. Chen, A.D. Aguirre, J.G. Fujimoto, Opt. Exp. 12(15), 3532 (2004)CrossRefGoogle Scholar
  37. 37.
    A.M. Karamzadeh, R. Jackson, S.G. Guo, J.M. Ridgway, H.S. Wong, G.S. Ahuja et al., Arch. Otolaryngol. Head Neck Surg. 131(6), 499 (2005)CrossRefPubMedGoogle Scholar
  38. 38.
    K. Luerssen, H. Lubatschowski, H. Gasse, R. Koch, M. Ptok, in Optical Characterization of Vocal Folds with Optical Coherence Tomography, ed. by E.B. Kenneth, S.B. Lawrence, T.W.D.R. Werner, W.G. Kenton, H. Henry, K. Abrahamet al., , (SPIE, Bellingham, WA, 2005), p. 328-332Google Scholar
  39. 39.
    B.J.F. Wong, R.P. Jackson, S. Guo, J.M. Ridgway, U. Mahmood, J. Su et al., Laryngoscope 1904 (2005)Google Scholar
  40. 40.
    C. Pitris, K.T. Saunders, J.G. Fujimoto, M.E. Brezinski, Arch. Otolaryngol. Head Neck Surg. 127(6), 637 (2001)PubMedGoogle Scholar
  41. 41.
    B.J. Wong, Y. Zhao, M. Yamaguchi, N. Nassif, Z. Chen, J.F. De Boer, Otolaryngol. Head Neck Surg. 130(3), 334 (2004)CrossRefPubMedGoogle Scholar
  42. 42.
    R. Heermann, C. Hauger, P.R. Issing, T. Lenarz, Laryngo-Rhino-Otologie 81(6), 400 (2002)CrossRefPubMedGoogle Scholar
  43. 43.
    I.V. Turchin, E.A. Sergeeva, L.S. Dolin, V.A. Kamensky, N.M. Shakhova, R. Richards-Kortum, J. Biomed. Opt. 10(6), 64024 (2005)CrossRefGoogle Scholar
  44. 44.
    O. Kleinsasser, J. Otolaryngol. Soc. Aust. 2(3), 8 (1968)PubMedGoogle Scholar
  45. 45.
    A. Trotti, L.A. Bellm, J.B. Epstein, D. Frame, H.J. Fuchs, C.K. Gwede et al., Radiother. Oncol. 66(3), 253 (2003)CrossRefPubMedGoogle Scholar
  46. 46.
    S.T. Sonis, L.S. Elting, D. Keefe, D.E. Peterson, M. Schubert, M. Hauer-Jensen et al., Cancer 100(9 Suppl), 1995 (2004)CrossRefPubMedGoogle Scholar
  47. 47.
    A. Trotti, S.M. Bentzen, J. Clin. Oncol. 22(1), 19 (2004)CrossRefPubMedGoogle Scholar
  48. 48. Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3. 0, 2003, DCTD, NCI, NIH, DHHSGoogle Scholar
  49. 49.
    T.M. Muanza, A.P. Cotrim, M. McAuliffe, A.L. Sowers, B.J. Baum, J.A. Cook et al., Clin. Cancer Res. 11(14), 5121 (2005)CrossRefPubMedGoogle Scholar
  50. 50.
    N. Gladkova, A. Maslennikova, A. Terentieva, Y. Fomina, N. Khomutinnikova, I. Balalaeva et al., in OCT Visualization of Acute Radiation Mucositis: Pilot Study, ed. by D. Wolfgang, (SPIE, Bellingham, WA, 2005), p. 58610T Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • A. B. Terentéva
  • A. V. Shakhov
  • A. V. Maslennikova
  • N. D. Gladkova
  • V. A. Kamensky
  • F. I. Feldchtein
  • N. M. Shakhova

There are no affiliations available

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