Retinal Optical Coherence Tomography

  • W. Drexler
  • J. G. Fujimoto
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

The eye is essentially transparent, transmitting light with only minimal optical attenuation and scattering, providing easy optical access to the anterior segment as well as the retina. For this reason, ophthalmic and especially retinal imaging has been not only the first, but also most successful clinical application for optical coherence tomography (OCT). This chapter focuses on the development of OCT technology for retinal imaging. OCT has significantly improved the potential for early diagnosis, understanding of retinal disease pathogenesis as well as monitoring disease progression and response to therapy. Development of ultrabroad bandwidth light sources and high speed detection techniques have enabled significant improvements in ophthalmic OCT imaging performance, demonstrating the potential of three-dimensional, ultrahigh resolution OCT (3D UHR OCT) to perform noninvasive optical biopsy of the living human retina, i.e., the in vivo visualization of microstructural, intraretinal morphology in situ approaching the resolution of conventional histopathology. Significant improvements in axial resolution and speed not only enable three-dimensional rendering of retinal volumes, but also high definition, 2D tomograms, topographic thickness maps of all major intraretinal layers as well as volumetric quantification of pathologic intraretinal changes. These advances in OCT technology have also been successfully applied in several animal models of retinal pathologies. The development of light sources emitting at alternative wavelengths, e.g., around ∼l,050 nm, not only enabled three-dimensional OCT imaging with enhanced choroidal visualization, but also improved OCT performance in cataract patients because of reduced scattering losses in this wavelength region. Adaptive optics using deformable mirror technology, with unique high stroke to correct higher order ocular aberrations, with specially designed optics to compensate chromatic aberration of the human eye, in combination with 3D UHR OCT, recently enabled in vivo cellular resolution retinal imaging.


Retinal Pigment Epithelium Macular Hole Internal Limit Membrane Optical Coherence Tomography Imaging Central Serous Chorioretinopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    T. Olsen, Acta Ophthalmol. Scand. 67, 141 (1990)Google Scholar
  2. 2.
    J.C. Bamber, M. Trstam, in The Physics of Medical Imaging, ed. by S. Webb (Adam Hilger, Bristol and Philadelphia, 1988), p. 319Google Scholar
  3. 3.
    J.C. Pavlin, J.A. McWhae, H.D. McGowan, F.S. Foster, Ophthalmology 99, 1220 (1992)PubMedGoogle Scholar
  4. 4.
    D.Z. Reinstein, R.H. Silverman, M.J. Rondeau, D.J. Coleman, Ophthamology 101(1), 140 (1994)Google Scholar
  5. 5.
    R.H. Webb, G.W. Hughes, F.C. Delori, Appl. Opt. 26, 1492 (1987)PubMedGoogle Scholar
  6. 6.
    R.H. Webb, Appl. Opt. 19, 2991 (1979)Google Scholar
  7. 7.
    J.F. Bille, A.W. Dreher, G. Zinser, in Noninvasive Diagnostic Techniques in Ophthalmology, ed. by B.R. Masters (Springer, Berlin Heidelberg New York, 1990), p. 528Google Scholar
  8. 8.
    A.F. Fercher, E. Roth, Proc. SPIE 658, 48 (1986)Google Scholar
  9. 9.
    J.G. Fujimoto, S. De Silvestri, E.P. Ippen, C.A. Puliafito, R. Marglois, A. Oseroff, Opt. Lett. 11, 150 (1986)PubMedGoogle Scholar
  10. 10.
    A.F. Fercher, K. Mengedoht, W. Werner, Opt. Lett. 13, 186 (1988)PubMedGoogle Scholar
  11. 11.
    D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, J.G. Fujimoto, Science 254(5035), 1178 (1991)PubMedGoogle Scholar
  12. 12.
    E.A. Swanson, J.A. Izatt, M.R. Hee, D. Huang, C.P. Lin, J.S. Schuman, C.A. Puliafito, J.G. Fujimoto, Opt. Lett. 18(21), 1864 (1993)PubMedGoogle Scholar
  13. 13.
    A.F. Fercher, C.K. Hitzenberger, W. Drexler, G. Kamp, H. Sattmann, Am. J. Ophthalmol. 116(1), 113 (1993)PubMedGoogle Scholar
  14. 14.
    J.G. Fujimoto, M.E. Brezinski, G.J. Tearney, S.A. Boppart, B. Bouma, M.R. Hee, J.F. Southern, E.A. Swanson, Nat. Med. 1(9), 970 (1995)PubMedGoogle Scholar
  15. 15.
    A.F. Fercher, J. Biomed. Opt. 1, 157 (1996)Google Scholar
  16. 16.
    J.G. Fujimoto, Nat. Biotechnol. 21(11), 1361 (2003)PubMedGoogle Scholar
  17. 17.
    M.R. Hee, J.A. Izatt, E.A. Swanson, D. Huang, J.S. Schuman, C.P. Lin, C.A. Puliafito, J.G. Fujimoto, Arch. Ophthalmol. 113(3), 325 (1995)PubMedGoogle Scholar
  18. 18.
    C.A. Puliafito, M.R. Hee, J.S. Schuman, J.G. Fujimoto, Optical Coherence Tomography of Ocular Disease (Slack Inc., Thorofare, NJ, 1995)Google Scholar
  19. 19.
    M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, J.G. Fujimoto, Invest. Ophthalmol. Vis. Sci. 36(4), S207 (1995)Google Scholar
  20. 20.
    M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, J.G. Fujimoto, Arch. Ophthalmol. 113(8), 1019 (1995)PubMedGoogle Scholar
  21. 21.
    M.R. Hee, C.A. Puliafito, C. Wong, E. Reichel, J.S. Duker, J.S. Schuman, E.A. Swanson, J.G. Fujimoto, Am. J. Ophthalmol. 120(1), 65 (1995)PubMedGoogle Scholar
  22. 22.
    J.S. Schuman, M.R. Hee, C.A. Puliafito, C. Wong, T. Pedutkloizman, C.P. Lin, E. Hertzmark, J.A. Izatt, E.A. Swanson, J.G. Fujimoto, Arch. Ophthalmol. 113(5), 586 (1995)PubMedGoogle Scholar
  23. 23.
    J.S. Schuman, T. PedutKloizman, E. Hertzmark, M.R. Hee, J.R. Wilkins, J.G. Coker, C.A. Puliafito, J.G. Fujimoto, E.A. Swanson, Ophthalmology 103(11), 1889 (1996)PubMedGoogle Scholar
  24. 24.
    M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, J.G. Fujimoto, Ophthalmology 105(2), 360 (1998)PubMedGoogle Scholar
  25. 25.
    R. Brancato, Documenta Ophthalmologica 97(3–4), 337 (1999)PubMedGoogle Scholar
  26. 26.
    A. Gaudric, B. Haouchine, P. Massin, M. Paques, P. Blain, A. Erginay, Arch. Ophthalmol. 117(6), 744 (1999)PubMedGoogle Scholar
  27. 27.
    M.E. Pons, R. Gurses-Ozden, H. Ishikawa, H.L. Dou, J.M. Liebmann, R. Ritch, Invest. Ophthalmol. Vis. Sci. 40(4), S839 (1999)Google Scholar
  28. 28.
    D.S. Chauhan, R.J. Antcliff, P.A. Rai, T.H. Williamson, J. Marshall, Arch. Ophthalmol. 118(1), 32 (2000)PubMedGoogle Scholar
  29. 29.
    P. Massin, C. Allouch, B. Haouchine, F. Metge, M. Paques, L. Tangui, A. Erginay, A. Gaudric, Am. J. Ophthalmol. 130(6), 732 (2000)PubMedGoogle Scholar
  30. 30.
    C. Bowd, L.M. Zangwill, C.C. Berry, E.Z. Blumenthal, C. Vasile, C. Sanchez-Galeana, C.F. Bosworth, P.A. Sample, Invest. Ophthalmol. Vis. Sci. 42(9), 1993 (2001)PubMedGoogle Scholar
  31. 31.
    C. Sanchez-Galeana, C. Bowd, E.Z. Blumenthal, P.A. Gokhale, L.M. Zangwill, R.N. Weinreb, Ophthalmology 108(10), 1812 (2001)PubMedGoogle Scholar
  32. 32.
    H. Sanchez-Tocino, A. Alvarez-Vidal, M.J. Maldonado, J. Moreno-Montanes, A. Garcia-Layana, Invest. Ophthalmol. Vis. Sci. 43(5), 1588 (2002)PubMedGoogle Scholar
  33. 33.
    R.F. Spaide, Retina-J. Retin. Vitreous Dis. 22(2), 183 (2002)Google Scholar
  34. 34.
    S. Muscat, S. Parks, E. Kemp, D. Keating, Invest. Ophthalmol. Vis. Sci. 43(2), 490 (2002)PubMedGoogle Scholar
  35. 35.
    R.F. Spaide, D. Wong, Y. Fisher, M. Goldbaum, Am. J. Ophthalmol. 133(2), 226 (2002)PubMedGoogle Scholar
  36. 36.
    C. Bowd, L.M. Zangwill, E.Z. Blumenthal, C. Vasile, A.G. Boehm, P.A. Gokhale, K. Mohammadi, P. Amini, T.M. Sankary, R.N. Weinreb, J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 19(1), 197 (2002)PubMedGoogle Scholar
  37. 37.
    J.S. Schuman, C.A. Puliafito, J.G. Fujimoto, Optical Coherence Tomography of Ocular Disease (Slack Inc., Thorofare, NJ, 2004)Google Scholar
  38. 38.
    W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, J.G. Fujimoto, Opt. Lett. 24(17), 1221 (1999)PubMedGoogle Scholar
  39. 39.
    W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kartner, J.S. Schuman, J.G. Fujimoto, Nat. Med. 7(4), 502 (2001)PubMedGoogle Scholar
  40. 40.
    W. Drexler, H. Sattmarin, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, A.F. Fercher, Arch. Ophthalmol. 121(5), 695 (2003)PubMedGoogle Scholar
  41. 41.
    W. Drexler, J. Biomed. Opt. 9(1), 47 (2004)PubMedGoogle Scholar
  42. 42.
    T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, J.S. Schuman, Ophthalmology 111(11), 2033 (2004)PubMedGoogle Scholar
  43. 43.
    E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, W. Drexler, Invest. Ophthalmol. Vis. Sci. 46(1), 310 (2005)PubMedGoogle Scholar
  44. 44.
    G. Wollstein, L.A. Paunescu, T.H. Ko, J.G. Fujimoto, A. Kowalevicz, I. Hartl, S. Beaton, H. Ishikawa, C. Mattox, O. Singh, J. Duker, W. Drexler, J.S. Schuman, Ophthalmology 112(2), 229 (2005)PubMedGoogle Scholar
  45. 45.
    T.H. Ko, J.G. Fujimoto, J.S. Schuman, L.A. Paunescu, A.M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, J.S. Duker, Ophthalmology 112(11), 1922 (2005)PubMedGoogle Scholar
  46. 46.
    M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber,M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, W. Drexler, Am. J. Ophthalmol. 140(6), 976 (2005)PubMedGoogle Scholar
  47. 47.
    L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, J.G. Fujimoto, Ophthalmology 113(1), 48 (2006)PubMedGoogle Scholar
  48. 48.
    T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, J.S. Duker, Arch. Ophthalmol. 124(6), 827 (2006)PubMedGoogle Scholar
  49. 49.
    C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, W. Drexler, Retina 26(9), 1034 (2006)PubMedGoogle Scholar
  50. 50.
    A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, J.S. Duker, Am. J. Ophthalmol. 142(6), 945 (2006)PubMedGoogle Scholar
  51. 51.
    M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, W. Drexler, Invest. Ophthalmol. Vis. Sci. 44(4), 1696 (2003)PubMedGoogle Scholar
  52. 52.
    E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, W. Drexler, Exp. Eye Res. 78(6), 1117 (2004)PubMedGoogle Scholar
  53. 53.
    P.K. Ahnelt,W. Drexler, Exp. Eye Res. 80(3), 449 (2005)Google Scholar
  54. 54.
    R.S. Ramrattan, T.L. van der Schaft, C.M. Mooy, W.C. de Bruijn, P.G. Mulder, P.T. de Jong, Invest. Ophthalmol. Vis. Sci. 35(6), 2857 (1994)PubMedGoogle Scholar
  55. 55.
    A. Okubo, R.H. Rosa, Jr., C.V. Bunce, R.A. Alexander, J.T. Fan, A.C. Bird, P.J. Luthert, Invest. Ophthalmol. Vis. Sci. 40(2), 443 (1999)PubMedGoogle Scholar
  56. 56.
    A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, V. Yakovlev, G. Tempea, C. Schubert, E.M. Anger, P.K. Ahnelt, M. Stur, J.E. Morgan, A. Cowey, G. Jung, T. Le, A. Stingl, Opt. Lett. 28(11), 905 (2003)PubMedGoogle Scholar
  57. 57.
    A.M. Rollins, M.D. Kulkarni, S. Yazdanfar, R. Ung-arunyawee, J.A. Izatt, Opt. Express 3(6), 219 (1998)PubMedGoogle Scholar
  58. 58.
    A.G. Podoleanu, G.M. Dobre, D.A. Jackson, Opt. Lett. 23(3), 147 (1998)PubMedGoogle Scholar
  59. 59.
    A.G. Podoleanu, M. Seeger, G.M. Dobre, D.J. Webb, D.A. Jackson, F. Fitzke, J. Biomed. Opt. 3, 12 (1998)Google Scholar
  60. 60.
    A.G. Podoleanu, J.A. Rogers, D.A. Jackson, Opt. Express 7(9), 292 (2000)PubMedGoogle Scholar
  61. 61.
    C.K. Hitzenberger, P. Trost, P.W. Lo, Q.Y. Zhou, Opt. Express 11(21), 2753 (2003)PubMedCrossRefGoogle Scholar
  62. 62.
    A.G. Podoleanu, G.M. Dobre, R.G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L.A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J.A. Rogers, S. Dunne, A. Boxer, J. Biomed. Opt. 9(1), 86 (2004)PubMedGoogle Scholar
  63. 63.
    G.M. Dobre, A.G. Podoleanu, R.B. Rosen, Opt. Lett. 30(1), 58 (2005)PubMedGoogle Scholar
  64. 64.
    R.G. Cucu, A.G. Podoleanu, J.A. Rogers, J. Pedro, R.B. Rosen, Opt. Lett. 31(11), 1684 (2006)PubMedGoogle Scholar
  65. 65.
    A.F. Fercher, C.K. Hitzenberger, G. Kamp, S.Y. El-Zaiat, Opt. Commn. 117, 43 (1995)Google Scholar
  66. 66.
    B. Golubovic, B.E. Bouma, G.J. Tearney, J.G. Fujimoto, Opt. Lett. 22(22), 1704 (1997)PubMedGoogle Scholar
  67. 67.
    F. Lexer, C.K. Hitzenberger, A.F. Fercher, M. Kulhavy, Appl. Opt. 36(25), 6548 (1997)PubMedGoogle Scholar
  68. 68.
    G. Häusler, M.W. Lindner, J. Biomed. Opt. 3, 21 (1998)Google Scholar
  69. 69.
    R. Leitgeb, C.K. Hitzenberger, A.F. Fercher, Opt. Express 11(8), 889 (2003)PubMedCrossRefGoogle Scholar
  70. 70.
    M.A. Choma, M.V. Sarunic, C.H. Yang, J.A. Izatt, Opt. Express 11(18), 2183 (2003)PubMedCrossRefGoogle Scholar
  71. 71.
    J.F. de Boer, B. Cense, B.H. Park, M.C. Pierce, G.J. Tearney, B.E. Bouma, Opt. Lett. 28(21), 2067 (2003)PubMedGoogle Scholar
  72. 72.
    M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, A.F. Fercher, J. Biomed. Opt. 7(3), 457 (2002)PubMedGoogle Scholar
  73. 73.
    S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, B.E. Bouma, Opt. Express 11(22), 2953 (2003)PubMedGoogle Scholar
  74. 74.
    N. Nassif, B. Cense, B.H. Park, S.H. Yun, T.C. Chen, B.E. Bouma, G.J. Tearney, J.F. de Boer, Opt. Lett. 29(5), 480 (2004)PubMedGoogle Scholar
  75. 75.
    R.A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, A.F. Fercher, Opt. Express 12(10), 2156 (2004)PubMedGoogle Scholar
  76. 76.
    M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, J.S. Duker, Opt. Express 12(11), 2404 (2004)PubMedGoogle Scholar
  77. 77.
    B. Cense, N.A. Nassif, T. Chen, M. Pierce, S.-H. Yun, B. Park, B. Bouma, G. Tearney, J. de Boer, Opt. Express 12(11), 2435 (2004)PubMedGoogle Scholar
  78. 78.
    R.A. Leitgeb, L. Schmetterer, W. Drexler, A.F. Fercher, R.J. Zawadzki, T. Bajraszewski, Opt. Express 11(23), 3116 (2003)PubMedGoogle Scholar
  79. 79.
    B.R. White, M.C. Pierce, N. Nassif, B. Cense, B.H. Park, G.J. Tearney, B.E. Bouma, T.C. Chen, J.F. de Boer, Opt. Express 11(25), 3490 (2003)PubMedCrossRefGoogle Scholar
  80. 80.
    M. Wojtkowski, A. Kowalczyk, R. Leitgeb, A.F. Fercher, Opt. Lett. 27(16), 1415 (2002)PubMedGoogle Scholar
  81. 81.
    R. Leitgeb, T. Bajraszewski, C.K. Hitzenberger, A.F. Fercher, Proc. SPIE 4956, 101 (2003)Google Scholar
  82. 82.
    R.A. Leitgeb, C.K. Hitzenberger, A.F. Fercher, T. Bajraszewski, Opt. Lett. 28(22), 2201 (2003)PubMedGoogle Scholar
  83. 83.
    M.A. Choma, C.H. Yang, J.A. Izatt, Opt. Lett. 28(22), 2162 (2003)PubMedGoogle Scholar
  84. 84.
    V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, J.G. Fujimoto, Ophthalmology 113(11), 2054 (2006)PubMedGoogle Scholar
  85. 85.
    Schmidt-Erfurth, U., R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, W. Drexler, Invest. Ophthalmol. Vis. Sci. 46(9), 3393 (2005)Google Scholar
  86. 86.
    B.K. Monson, P.B. Greenberg, E. Greenberg, J.G. Fujimoto, V.J. Srinivasan, J.S. Duker, Br. J. Ophthalmol. 91(1), 119 (2007)PubMedGoogle Scholar
  87. 87.
    G. Karan, C. Lillo, Z. Yang, D.J. Cameron, K.G. Locke, Y. Zhao, S. Thirumalaichary, C. Li, D.G. Birch, H.R. Vollmer-Snarr, D.S. Williams, K. Zhang, Proc. Natl. Acad. Sci. USA 102(11), 4164 (2005)PubMedGoogle Scholar
  88. 88.
    J. Ambati, A. Anand, S. Fernandez, E. Sakurai, B.C. Lynn, W.A. Kuziel, B.J. Rollins, B.K. Ambati, Nat. Med. 9(11), 1390 (2003)PubMedGoogle Scholar
  89. 89.
    V.J. Srinivasan, T.H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S.E. Bursell, Q.H. Song, J. Lem, J.S. Duker, J.S. Schuman, J.G. Fujimoto, Invest. Ophthalmol. Vis. Sci. 47(12), 5522 (2006)PubMedGoogle Scholar
  90. 90.
    D.C. Fernandez, H.M. Salinas, C.A. Puliafito, Opt. Express 13(25), 10200 (2005)Google Scholar
  91. 91.
    M. Mujat, R.C. Chan, B. Cense, B.H. Park, C. Joo, T. Akkin, T.C. Chen, J.F. de Boer, Opt. Express 13(23), 9480 (2005)PubMedGoogle Scholar
  92. 92.
    D. Koozekanani, K. Boyer, C. Roberts, IEEE Trans. Med. Imaging 20(9), 900 (2001)PubMedGoogle Scholar
  93. 93.
    R.O. Duda, P.E. Hart, D.G. Stork, Pattern Classification (Wiley Interscience, New York, 2001)Google Scholar
  94. 94.
    R.C. Gonzalez, R.E. Woods, Digital Image Processing (Prentice Hall, Englewood Cliffs, NJ, 2002)Google Scholar
  95. 95.
    B. Povazay, K. Bizheva, B. Hermann, A. Unterhuber, H. Sattmann, A.F. Fercher, W. Drexler, C. Schubert, P.K. Ahnelt, M. Mei, R. Holzwarth, W.J. Wadsworth, J.C. Knight, P.S. Russel, Opt. Express 11(17), 1980 (2003)PubMedGoogle Scholar
  96. 96.
    A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, W. Drexler, Opt. Express 13(9), 3252 (2005)PubMedGoogle Scholar
  97. 97.
    B. Povazay, B. Hermann, A. Unterhuber, S.H.F. Zeiler, J.E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Binder, W. Drexler, J. Biomed. Opt.12(4), 041211 (2007)PubMedGoogle Scholar
  98. 98.
    S.H. Yun, G.J. Tearney, B.E. Bouma, B.H. Park, J.F. de Boer, Opt. Express 11(26), 3598 (2003)PubMedCrossRefGoogle Scholar
  99. 99.
    K. Bizheva, R. Pflug, B. Hermann, B. Povazay, H. Sattmann, P. Qiu, E. Anger, H. Reitsamer, S. Popov, J.R. Taylor, A. Unterhuber, P. Ahnelt, W. Drexler, Proc. Natl. Acad. Sci. USA 103(13), 5066 (2006)PubMedGoogle Scholar
  100. 100.
    V.J. Srinivasan, M. Wojtkowski, J.G. Fujimoto, J.S. Duker, Opt. Lett. 31(15), 2308 (2006)PubMedGoogle Scholar
  101. 101.
    B. Povazay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J.E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, W. Drexler, J. Biomed. Opt. 12(4), 041211 (2007)PubMedGoogle Scholar
  102. 102.
    S.R. Chinn, E.A. Swanson, J.G. Fujimoto, Opt. Lett. 22(5), 340 (1997)PubMedGoogle Scholar
  103. 103.
    S.H. Yun, G.J. Tearney, J.F. de-Boer, N. Iftimia, B.E. Bouma, Opt. Express 11(22), 2953 (2003)Google Scholar
  104. 104.
    S.H. Yun, C. Boudoux, G. Tearney, B.E. Bouma, Opt. Lett. 28(20), 1981 (2003)PubMedGoogle Scholar
  105. 105.
    W.Y. Oh, S.H. Yun, G.J. Tearney, B.E. Bouma, Opt. Lett. 30(23), 3159 (2005)PubMedGoogle Scholar
  106. 106.
    E.C.W. Lee, J.F. de Boer, M. Mujat, H. Lim, S.H. Yun, Opt. Express 14(10), 4403 (2006)PubMedGoogle Scholar
  107. 107.
    H. Lim, M. Mujat, C. Kerbage, E.C.W. Lee, Y. Chen, T.C. Chen, J.F. de Boer, Opt. Express 14(26), 12902 (2006)PubMedGoogle Scholar
  108. 108.
    V.J. Srinivasan, R. Huber, I. Gorczynska, J. Fujimoto, J.Y. Jiang, P. Reisen, A.E. Cable, Opt. Lett. 32(4), 361 (2007)PubMedGoogle Scholar
  109. 109.
    R. Huber, M. Wojtkowski, K. Taira, J.G. Fujimoto, K. Hsu, Opt. Express 13(9), 3513 (2005)PubMedGoogle Scholar
  110. 110.
    R. Huber, M. Wojtkowski, J.G. Fujimoto, Opt. Express 14(8), 3225 (2006)PubMedGoogle Scholar
  111. 111.
    R. Huber, D.C. Adler, J.G. Fujimoto, Opt. Lett. 31(20), 2975 (2006)PubMedGoogle Scholar
  112. 112.
    D.C. Adler, R. Huber, J.G. Fujimoto, Opt. Lett. 32(6), 626 (2007)PubMedGoogle Scholar
  113. 113.
    R. Huber, D.C. Adler, V. Srinivasan, J.G. Fujimoto, Opt. Lett. 32(14), 2049 (2007)PubMedGoogle Scholar
  114. 114.
    H.C. Howland, B. Howland, J. Opt. Soc. Am. 67, 1508 (1977)PubMedGoogle Scholar
  115. 115.
    P. Artal, R. Navarro, Opt. Lett. 14, 1098 (1989)PubMedGoogle Scholar
  116. 116.
    H. Hofer, L. Chen, G.Y. Yoon, B. Singer, Y. Yamauchi, D.R. Williams, Opt. Express 8, 631 (2001)PubMedGoogle Scholar
  117. 117.
    J.Z. Liang, D.R. Williams, D.T. Miller, J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 14(11), 2884 (1997)PubMedGoogle Scholar
  118. 118.
    F. Vargas-Martin, P.M. Prieto, P. Artal, J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 15(9), 2552 (1998)PubMedGoogle Scholar
  119. 119.
    E.J. Fernandez, I. Iglesias, P. Artal, Opt. Lett. 26(10), 746 (2001)PubMedGoogle Scholar
  120. 120.
    A. Roorda, D.R. Williams, Nature 397(6719), 520 (1999)PubMedGoogle Scholar
  121. 121.
    H. Hofer, L. Chen, G.-Y. Yoon, B. Singer, Y. Yamauchi, D.R. Williams, Opt. Express 8(11), 631 (2001)PubMedGoogle Scholar
  122. 122.
    A. Roorda, F. Romero-Borja, W.J. Donnelly, H. Queener, T.J. Hebert, M.C.W. Campbell, Opt. Express 10(9), 405 (2002)PubMedGoogle Scholar
  123. 123.
    D.C. Gray, W. Merigan, J.I. Wolfing, B.P. Gee, J. Porter, A. Dubra, T.H. Twietmeyer, K. Ahmad, R. Tumbar, F. Reinholz, D.R. Williams, Opt. Express 14(16), 7144 (2006)PubMedGoogle Scholar
  124. 124.
    D.T. Miller, J. Qu, R.S. Jonnal, K. Thorn, Proc. SPIE 4956, 65 (2003)Google Scholar
  125. 125.
    B. Hermann, E.J. Fernandez, A. Unterhuber, H. Sattmann, A.F. Fercher, W. Drexler, P.M. Prieto, P. Artal, Opt. Lett. 29(18), 2142 (2004)PubMedGoogle Scholar
  126. 126.
    E.J. Fernandez, B. Povazay, B. Hermann, A. Unterhuber, H. Sattmann, P.M. Prieto, R. Leitgeb, P. Ahnelt, P. Artal, W. Drexler, Vis. Res. 45(28), 3432 (2005)PubMedGoogle Scholar
  127. 127.
    Y. Zhang, J.T. Rha, R.S. Jonnal, D.T. Miller, Opt. Express 13(12), 4792 (2005)PubMedGoogle Scholar
  128. 128.
    Y. Zhang, B. Cense, J. Rha, R.S. Jonnal, W. Gao, R.J. Zawadzki, J.S. Werner, S. Jones, S. Olivier, D.T. Miller, Opt. Express 14(10), 4380 (2006)PubMedGoogle Scholar
  129. 129.
    R.J. Zawadzki, S.M. Jones, S.S. Olivier, M.T. Zhao, B.A. Bower, J.A. Izatt, S. Choi, S. Laut, J.S. Werner, Opt. Express 13(21), 8532 (2005)PubMedGoogle Scholar
  130. 130.
    E.J. Fernandez, A. Unterhuber, P.M. Prieto, B. Hermann,W. Drexler, P. Artal, Opt. Express 13(2), 400 (2005)PubMedGoogle Scholar
  131. 131.
    E.J. Fernandez, W. Drexler, Opt. Express 13(20), 8184 (2005)PubMedGoogle Scholar
  132. 132.
    E.J. Fernandez, A. Unterhuber, B. Povazay, B. Hermann, P. Artal, W. Drexler, Opt. Express 14(13), 6213 (2006)PubMedGoogle Scholar
  133. 133.
    E.J. Fernandez, L. Vabre, B. Hermann, A. Unterhuber, B. Povazay,W. Drexler, Opt. Express 14(20), 8900 (2006)PubMedGoogle Scholar
  134. 134.
    H.P. Scholl, E. Zrenner, Surv. Ophthalmol. 45(1), 29 (2000)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • W. Drexler
    • 1
  • J. G. Fujimoto
    • 2
  1. 1.School of Optometry and Vision SciencesCardiff UniversityCardiffUK
  2. 2.Department of Electrical Engineering and Computer ScienceMassachusetts Institute of TechnologyCambridgeUSA

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