Modeling Light–Tissue Interaction in Optical Coherence Tomography Systems

  • P. E. Andersen
  • T. M. Jørgensen
  • L. Thrane
  • A. Tycho
  • H. T. Yura
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Optical coherence tomography (OCT) has developed rapidly since its potential for applications in clinical medicine was first demonstrated in 1991 [1]. OCT performs high-resolution, cross-sectional tomographic imaging of the internal microstructure in materials and biologic systems by measuring backscattered or backreflected light.

The scope of this chapter is to present analytical and numerical models that are able to describe the performance of OCT systems, including multiple scattering effects in heterogeneous media. Such models, where the contribution to the OCT signal from multiple scattering effects is taken into account, are essential for the understanding and in turn optimization of OCT systems. An analytical model based on the extended Huygens–Fresnel (EHF) principle meeting these requirements is presented here. A novel MC analysis is presented in order to handle the modeling of heterodyne/coherent detection OCT systems with a radiative transfer type photon packet MC approach. Using this MC model results are obtained, which validate the EHF model. In general, these models, analytical as well as numerical, may serve as important tools for improving interpretation of OCT images.


Optical Coherence Tomography Monte Carlo Monte Carlo Simulation Multiple Scattering Optical Coherence Tomography Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, J.G. Fujimoto, Science 254, 1178 (1991)CrossRefPubMedGoogle Scholar
  2. 2.
    J.M. Schmitt, A. Knsüttel, R.F. Bonner, Appl. Opt. 32, 6032 (1993)CrossRefGoogle Scholar
  3. 3.
    J.M. Schmitt, A. Knsüttel, A.S. Gandjbakhche, R.F. Bonner, Proc. SPIE 1889, 197(1993)CrossRefGoogle Scholar
  4. 4.
    J.M. Schmitt, A.Knsüttel, M. Yadlowsky, M.A. Eckhaus, Phys. Med. Biol. 39, 1705(1994)CrossRefGoogle Scholar
  5. 5.
    M.J. Yadlowsky, J.M. Schmitt, R.F. Bonner, Appl. Opt. 34, 5699 (1995)CrossRefGoogle Scholar
  6. 6.
    M.J. Yadlowsky, J.M. Schmitt, R.F. Bonner, Proc. SPIE 2387, 193 (1995)CrossRefGoogle Scholar
  7. 7.
    Y. Pan, R. Birngruber, R. Engelhardt, Appl. Opt. 36, 2979 (1997)CrossRefPubMedGoogle Scholar
  8. 8.
    L.S. Dolin, Radiophys. Quant. Electron. 41, 850 (1998)CrossRefGoogle Scholar
  9. 9.
    J.M. Schmitt, A. Knüttel, J. Opt. Soc. Am. A 14, 1231 (1997)CrossRefGoogle Scholar
  10. 10.
    D.J. Smithies, T. Lindmo, Z. Chen, J.S. Nelson, T.E. Milner, Phys. Med. Biol. 43,3025 (1998)CrossRefPubMedGoogle Scholar
  11. 11.
    A.F. Fercher, W. Drexler, C.K. Hitzenberger, T. Lasser, Rep. Prog. Phys. 66, 239 (2003)CrossRefGoogle Scholar
  12. 12.
    L. Thrane, H.T. Yura, P.E. Andersen, J. Opt. Soc. Am. A 17, 484 (2000)CrossRefGoogle Scholar
  13. 13.
    I.V. Turchin, E.A. Sergeeva, L.S. Dolin, V.A. Kamensky, N.M. Shakhova, R. Richards-Kortum, J. Biomed. Opt. 10, 064024 (2005)CrossRefPubMedGoogle Scholar
  14. 14.
    A. Tycho, T.M. JT.M.Jørgensen, H.T. Yura, P.E. Andersen, Appl. Opt. 41, 6676 (2002)CrossRefPubMedGoogle Scholar
  15. 15.
    H. Kahn, T.E. Harris, in Monte Carlo Methods. National Bureau of Standards Applied Mathematics Series, vol. 12 (U.S. Government Printing Office, 1951)Google Scholar
  16. 16.
    B.C. Wilson, G. Adam, Med. Phys. 10, 824 (1983)CrossRefPubMedGoogle Scholar
  17. 17.
    Y. Feng, R. Wang, J. Elder, J. Opt. Soc. Am. A 20, 1792 (2003)CrossRefGoogle Scholar
  18. 18.
    H.T. Yura, Opt. Acta 26, 627 (1979)Google Scholar
  19. 19.
    B. Karamata, M. Laubscher, M. Leutenegger, S. Bourquin, T. Lasser, P. Lambelet, J. Opt. Soc. Am. A 22, 1369-1379 (2005) CrossRefGoogle Scholar
  20. 20.
    J.W. Goodman, Statistical Optics (Wiley, New York, 1985)Google Scholar
  21. 21.
    R.G. Frehlich, M.J. Kavaya, Appl. Opt. 30, 5325 (1991) CrossRefGoogle Scholar
  22. 22.
    D. Arnush, J. Opt. Soc. Am. 62, 1109 (1972)CrossRefGoogle Scholar
  23. 23.
    H.T. Yura, in Proceedings of the Union Radio-Scientifique International Open Symposium, La Baule, France, 1977, pp. 65-69; see also Ref. [44], pp. 54-55 Google Scholar
  24. 24.
    H.T. Yura, L. Thrane, P.E. Andersen, J. Opt. Soc. Am. A 17, 2464 (2000)CrossRefGoogle Scholar
  25. 25.
    M.G. Raymer, C. Cheng, D.M. Toloudis, M. Anderson, M. Beck, in Advances in Optical Imaging and Photon Migration, ed. by R.R. Alfano, J.G. Fujimoto. OSA Trends in Optics and Photonics Series, vol. 2 (Optical Society of America, Washington, D.C., 1996), pp. 236-238; C.-C. Cheng, M.G. Raymer, Phys. Rev. Lett. 82, 4807 (1999); M.G. Raymer, C.-C. Cheng, in Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, ed. by D.D. Duncan, J.O. Hollinger, S.L. Jacques, Proc. SPIE 3914, 376 (2000)Google Scholar
  26. 26.
    G. Yao, L.V. Wang, Phys. Med. Biol. 44, 2307 (1999)CrossRefPubMedGoogle Scholar
  27. 27.
    P.E. Andersen, L. Thrane, H.T. Yura, A. Tycho, T.M. Jørgensen, M.H. Frosz, Phys. Med. Biol. 49, 1307 (2004)CrossRefPubMedGoogle Scholar
  28. 28.
    L. Thrane, H.T. Yura, P.E. Andersen, Proc. SPIE 3915, 2 (2000)CrossRefGoogle Scholar
  29. 29.
    I. Dror, A. Sandrov, N.S. Kopeika, Appl. Opt. 37, 6495 (1998)CrossRefPubMedGoogle Scholar
  30. 30.
    J.M. Schmitt, G. Kumar, Opt. Lett. 21, 1310 (1996)CrossRefPubMedGoogle Scholar
  31. 31.
    J. Strohbehn (ed.), Laser Beam Propagation in the Atmosphere, (Springer, New York, 1978)Google Scholar
  32. 32.
    R.L. Fante, in Progress in Optics XXII, ed. by E. Wolf (Elsevier, New York, 1985)Google Scholar
  33. 33.
    S.M. Rytov, Y.A. Kravtsov, V.I. Tatarskii, in Wave Propagation Through Random Media, vol. 4 (Springer, Berlin, 1989)Google Scholar
  34. 34.
    A. Ishimaru, Wave Propagation and Scattering in Random Media (IEEE Press, Piscataway, New Jersey, 1997)Google Scholar
  35. 35.
    R.F. Lutomirski, H.T. Yura, Appl. Opt. 10, 1652 (1971)CrossRefGoogle Scholar
  36. 36.
    Z.I. Feizulin, Y.A. Kravtsov, Izv. Vyssh. Uchebn. Zaved. Radiofiz. 24, 1351 (1967)Google Scholar
  37. 37.
    J.W. Goodman, Introduction to Fourier Optics, 2nd edn. (McGraw-Hill, Singapore, 1996)Google Scholar
  38. 38.
    H.T. Yura, S.G. Hanson, J. Opt. Soc. Am. A 4, 1931 (1987)CrossRefGoogle Scholar
  39. 39.
    H.T. Yura, S.G. Hanson, J. Opt. Soc. Am. A 6, 564 (1989)CrossRefGoogle Scholar
  40. 40.
    A.E. Siegman, Lasers (University Science Books, Mill Valley, California, 1986), pp. 626-630Google Scholar
  41. 41.
    M.J.C. Van Gemert, S.L. Jacques, H.J.C.M. Sterenborg, W.M. Star, IEEE Trans. Biomed. Eng. 36, 1146 (1989)CrossRefPubMedGoogle Scholar
  42. 42.
    C.F. Bohren, D.R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983)Google Scholar
  43. 43.
    D.L. Fried, Proc. IEEE 55, 57 (1967)CrossRefGoogle Scholar
  44. 44.
    L. Thrane, PhD Dissertation, Risø National Laboratory, Denmark, 2000, ISBN 87-550-2771-7Google Scholar
  45. 45.
    L.G. Henyey, J.L. Greenstein, Astrophys. J. 93, 70 (1941)CrossRefGoogle Scholar
  46. 46.
    S.L. Jacques, C.A. Alter, S.A. Prahl, Lasers Life Sci. 1, 309 (1987)Google Scholar
  47. 47.
    C.M. Sonnenschein, F.A. Horrigan, Appl. Opt. 10, 1600 (1971)CrossRefGoogle Scholar
  48. 48.
    V.V. Tuchin, S.R. Utz, I.V. Yaroslavsky, in Medical Optical Tomography: Functional Imaging and Monitoring, IS 11, ed. by G. Mueller, B. Chance, R. Alfano et al. (SPIE Press, Bellingham, Washington, 1993), pp. 234-258Google Scholar
  49. 49.
    J.A. Izatt, M.D. Kulkarni, S. Yazdanfar, J.K. Barton, A.J. Welch, Opt. Lett. 22, 1439 (1997)CrossRefPubMedGoogle Scholar
  50. 50.
    Z. Chen, T.E. Milner, D. Dave, J.S. Nelson, Opt. Lett. 22, 64 (1997)CrossRefPubMedGoogle Scholar
  51. 51.
    Y. Zhao, Z. Chen, C. Saxer, Q. Shen, S. Xiang, J.F. de Boer, J.S. Nelson, Opt. Lett. 25, 1358 (2000)CrossRefPubMedGoogle Scholar
  52. 52.
    H. Ren, K.M. Brecke, Z. Ding, Y. Zhao, J.S. Nelson, Z. Chen, Opt. Lett. 27, 409 (2002)CrossRefPubMedGoogle Scholar
  53. 53.
    S. Yazdanfar, A.M. Rollins, J.A. Izatt, Opt. Lett. 25, 1448 (2000)CrossRefPubMedGoogle Scholar
  54. 54.
    H.T. Yura, L. Thrane, manuscript in preparationGoogle Scholar
  55. 55.
    T. Lindmo, D.J. Smithies, Z. Chen, J.S. Nelson, T.E. Milner, Phys. Med. Biol. 43, 3045 (1998)CrossRefPubMedGoogle Scholar
  56. 56.
    A.N. Yaroslavsky, I.V. Yaroslavsky, T. Goldbach, H.-J. Schwarzmaier, J. Biomed. Opt. 4, 47 (1999)CrossRefGoogle Scholar
  57. 57.
    A. Tycho, T.M. Jsørgensen, Appl. Opt. 41, 4709 (2002)CrossRefPubMedGoogle Scholar
  58. 58.
    V.R. Daria, C. Saloma, S. Kawata, Appl. Opt. 39, 5244 (2000)CrossRefPubMedGoogle Scholar
  59. 59.
    Q. Lu, X. Gan, M. Gu, Q. Luo, Appl. Opt. 43, 1628 (2004)CrossRefPubMedGoogle Scholar
  60. 60.
    J. Schmitt, A. Knsüttel, M. Yadlowski, J. Opt. Soc. A 11, 2226 (1994)CrossRefGoogle Scholar
  61. 61.
    J.M. Schmitt, K. Ben-Letaief, J. Opt. Soc. Am. A 13, 952 (1996)CrossRefGoogle Scholar
  62. 62.
    C.M. Blanca, C. Saloma, Appl. Opt. 37, 8092 (1998)CrossRefPubMedGoogle Scholar
  63. 63.
    Y. Pan, R. Birngruber, J. Rosperich, R. Engelhardt, Appl. Opt. 34, 6564 (1995)CrossRefGoogle Scholar
  64. 64.
    G. Yao, L.V. Wang, Phys. Med. Biol. 44, 2307 (1999)CrossRefPubMedGoogle Scholar
  65. 65.
    L.-H. Wang, S.L. Jacques, L.-Q. Zheng, Comput. Methods. Prog. Biomed. 47, 131 (1995)CrossRefGoogle Scholar
  66. 66.
    S.A. Prahl, M. Keijzer, S.L. Jacques, A.J. Welch, in Dosimetry of Laser Radiation in Medicine and Biology, SPIE Institute Series IS 5 (SPIE Press, Bellingham, Washington, 1998)Google Scholar
  67. 67.
    L. Thrane, M.H. Frosz, A. Tycho, T.M.Jsørgensen, H.T.Yura, P.E.Andersen, Opt. Lett. 29, 1641 (2004)CrossRefPubMedGoogle Scholar
  68. 68.
    D.I. Hughes, F.A. Duck, Ultrasound Med. Biol. 23, 651 (1997)CrossRefPubMedGoogle Scholar
  69. 69.
    A.Knsüttel, S. Bonev, W. Knaak, J. Biomed. Opt. 9, 265 (2004)CrossRefGoogle Scholar
  70. 70.
    M. Stone, J. Royal Static. Soc. B 36, 111 (1974)Google Scholar
  71. 71.
    G.J. Tearney, S.A. Boppart, B.E. Bouma, M.E. Brezinski, N.J. Weissman, J.F. Southern, J.G. Fujimoto, Opt. Lett. 21, 543 (1996)CrossRefPubMedGoogle Scholar
  72. 72.
    L. Thrane, T.M.Jsørgensen, P.E. Andersen, H.T. Yura, Proc. SPIE 4619, 36 (2002)CrossRefGoogle Scholar
  73. 73.
    R.O. Esenaliev, K.V. Larin, I.V. Larina, M. Motamedi, Opt. Lett. 26, 992 (2001)CrossRefPubMedGoogle Scholar
  74. 74.
    K.V. Larin, T. Akkin, R.O. Esenaliev, M. Motamedi, T.E. Milner, Appl. Opt. 43, 3408 (2004)CrossRefPubMedGoogle Scholar
  75. 75.
    D.J. Faber, M.C.G. Aalders, E.G. Mik, B.A. Hooper, M.J.C. van Gemert, T.G. van Leeuwen, Phys. Rev. Lett. 93, 028102-1 (2004)CrossRefPubMedGoogle Scholar
  76. 76.
    D.J. Faber, E.G. Mik, M.C.G. Aalders, T.G. van Leeuwen, Opt. Lett. 30, 1015 (2005)CrossRefPubMedGoogle Scholar
  77. 77.
    F.J. van der Meer, D.J. Faber, D.M.B. Sassoon, M.C. Aalders, G. Pasterkamp, T.G. van Leeuwen, IEEE Trans. Med. Imaging 24, 1369 (2005)CrossRefPubMedGoogle Scholar
  78. 78.
    N.M. Shakhova, V.M. Gelikonov, V.A. Kamensky, R.V. Kuranov, I.V. Turchin, Laser Phys. 12, 617 (2002)Google Scholar
  79. 79.
    D. Levitz, L. Thrane, M.H. Frosz, P.E. Andersen, C.B. Andersen, J. Valanciunaite, J. Swartling, S. Andersson-Engels, P.R. Hansen, pt. Exp. 12, 249 (2004)Google Scholar
  80. 80.
    H.T. Yura, S.G. Hanson, J. Opt. Soc. Am. A 13, 1891 (1996)CrossRefGoogle Scholar
  81. 81.
    V.I. Tatarskii, The Effects of the Turbulent Atmosphere on Wave Propagation (National Technical Information Service, Springfield, VA, 1971)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • P. E. Andersen
  • T. M. Jørgensen
  • L. Thrane
  • A. Tycho
  • H. T. Yura

There are no affiliations available

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