Optical Coherence Tomography in Tissue Engineering

  • S. A. Boppart
  • Y. Yang
  • R. K. Wang
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

As life expectancy increases and mortality rates decrease in the developed world, tissue replacement is frequently required to treat biological wear and tear associated with ageing [1, 2]. Despite the rapid development of modern clinical technologies, the field of medicine faces major challenges in finding solutions for such ageing-linked degeneration, disease or trauma. Autologous grafting still remains the gold standard for repair and replacement of tissues and organs. Viability, immunocompetence and high incorporation rate are the main advantages of autologous grafting. However, donor site morbidity and the risk of infection and limited availability are the common drawbacks of this procedure. The use of allogeneic tissue or organs offers another option, but the graft immunogenicity and the risk of infection and disease transmission lead to high rates of failure. A third option for repair and replacement of the tissue and organs is the use of a prosthesis made from synthetic materials, which has gained wide acceptance in certain situations, such as orthopaedic surgery, where total hip replacement is now a standard practice. The main problem of this technique, however, is premature failure due to lack of biocompatibility. This often leads to a short service time and malfunction of the prosthesis.


Optical Coherence Tomography Tissue Engineering Engineer Tissue Optical Coherence Tomography Image Multiphoton Microscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • S. A. Boppart
  • Y. Yang
  • R. K. Wang

There are no affiliations available

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