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Molecular OCT Contrast Enhancement and Imaging

  • A. L. Oldenburg
  • B. E. Applegate
  • J. A. Izatt
  • S. A. Boppart
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

The invention of the light microscope in the seventeenth century marked the advent of morphology, the ability to interpret visual input (images) in terms of the structure and interactions between cells and organelles. Microscopy in the nineteenth century saw increased popularity in the use of stains such as hemotoxylin and eosin because they provided additional, chemical information about the specimen, and thus histochemistry was born [1]. An analogous sequence of events is currently occurring in biomedical imaging, albeit on a shorter time scale. Although imaging modalities such as MRI, CT, and ultrasound have greatly advanced our understanding of the human body, physicians and biomedical researchers alike want to directly observe biochemical processes. Researchers today seek information about protein binding and gene expression to provide information about underlying physiological processes and early hallmarks of disease. This has led to an explosion of development in the field of “molecular imaging,” [2, 3] that is, the tracking and imaging of specific molecular species in a biological context. The combination of spatial and morphological data with the ability to track biochemical processes in the body will undoubtedly result in a wealth of new discoveries in biology and medicine. OCT, in particular, plays a crucial role in molecular imaging because of its ability for noninvasive optical biopsy on a microscopic resolution scale, which may ultimately replace the need for time-consuming histological analysis of biopsied tissue.

Keywords

Contrast Agent Surface Plasmon Resonance Iron Oxide Nanoparticles Exogenous Contrast Agent Optical Molecular Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  • A. L. Oldenburg
  • B. E. Applegate
  • J. A. Izatt
  • S. A. Boppart

There are no affiliations available

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