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Doppler Optical Coherence Tomography

  • Z. Chen
  • J. Zhang
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Optical coherence tomography (OCT) is a recently developed imaging modality based on coherence-domain optical technology [1–4]. OCT uses coherence gating of backscattered light for tomographic imaging of tissue structure. Variations in tissue scattering due to inhomogeneities in the optical index of refraction provide imaging contrast. However, in many instances and especially during early stages of disease, the change in tissue scattering properties between normal and diseased tissue is small and difficult to measure. One of the greatest challenges for extending clinical applications of OCT is to find more contrast mechanisms that can provide physiological information in addition to morphological structure. A number of extensions of OCT capabilities for functional imaging of tissue physiology have been developed. Doppler OCT, also named optical Doppler tomography (ODT), combines the Doppler principle with OCT to obtain high-resolution tomographic images of tissue structure and blood flow simultaneously [5–13]. Spectroscopic OCT combines spectroscopic analysis with OCT to obtain the depth resolved tissue absorption spectra [14–16]. Polarization sensitive OCT (PS-OCT) combines polarization sensitive detection with OCT to determine tissue birefringence [17–21]. Second harmonic optical coherence tomography (SHOCT) combines second harmonic generation with coherence gating to obtain images with molecular contrast [22]. These functional extensions of OCT provide clinically important information on tissue physiology, such as tissue blood perfusion, oxygen saturation, hemodynamics, and structural remodeling. Each provides several potential clinical applications, such as vasoactive drug screening, tissue viability and burn depth determination, tumor angiogenesis studies and cancer diagnosis, bleeding ulcer management, and ocular pathology evaluation [10,11,20,23–25]. This chapter reviews the principle and clinical applications of Doppler OCT.

Keywords

Optical Coherence Tomography Fourier Domain Doppler Spectrum Doppler Frequency Shift Port Wine Stain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Z. Chen
  • J. Zhang

There are no affiliations available

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