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Introduction to Optical Coherence Tomography

  • J. Fujimoto
  • W. Drexler
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Optical coherence tomography (OCT) is an emerging optical imaging modality in biomedical optics and medicine. OCT performs high resolution, cross-sectional imaging of the internal microstructure in biological tissues by measuring echoes of backscattered light [1]. Tissue pathology can be imaged in situ and in real time with resolutions of 1–15 μm, one to two orders of magnitude finer than conventional ultrasound. The unique features of OCT make it a powerful imaging modality, which promises to enable many fundamental research and clinical applications.

OCT performs cross-sectional imaging by measuring the magnitude and echo time delay of backscattered light. Cross-sectional images are generated by performing multiple axial measurements of echo time delay (axial scans or A-scans) and scanning the incident optical beam transversely, as shown in Fig. 1.1. This produces a two-dimensional data set, which represents the optical backscattering in a cross-sectional plane through the tissue. Images, or B-scans, can be displayed in false color or grey scale to visualize tissue pathology. Three-dimensional, volumetric data sets can be generated by acquiring sequential cross-sectional images by scanning the incident optical beam in a raster pattern. Three-dimensional OCT (3D-OCT) data contain comprehensive volumetric structural information and can be manipulated similar to MR or CT images.

Keywords

Optical Coherence Tomography Optical Coherence Tomography Imaging Axial Resolution Axial Scan Optical Coherence Tomography System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • J. Fujimoto
    • 1
  • W. Drexler
    • 2
  1. 1.Department of Electrical Engineering and Computer ScienceMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.School of Optometry and Vision SciencesCardiff UniversityCardiffUK

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