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Small Molecule Receptors as Imaging Targets

  • Aviv Hagooly
  • Raffaella Rossin
  • Michael J. WelchEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 185/2)

Abstract

The aberrant expression and function of certain receptors in tumours and other diseased tissues make them preferable targets for molecular imaging. PET and SPECT radionuclides can be used to label specific ligands with high affinity for the target receptors. The functional information obtained from imaging these receptors can be used to better understand the systems under investigation and for diagnostic and therapeutic applications. This review discusses some of the aspects of receptor imaging with small molecule tracers by PET and SPECT and reviews some of the tracers for the receptor imaging of tumours and brain, heart and lung disorders.

Keywords

Positron Emission Tomography Positron Emission Tomography Imaging Positron Emission Tomography Tracer Sigma Receptor Ligand Small Molecule Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Aviv Hagooly
    • 1
  • Raffaella Rossin
    • 1
  • Michael J. Welch
    • 1
    Email author
  1. 1.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. Louis

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