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Molecular Imaging-guided Gene Therapy of Gliomas

  • Maria A. Rueger
  • Alexandra Winkeler
  • Anne V. Thomas
  • Lutz W. Kracht
  • Andreas H. JacobsEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 185/2)

Abstract

Gene therapy of patients with glioblastoma using viral and non-viral vectors, which are applied by direct injection or convection-enhanced delivery (CED), appear to be satisfactorily safe. Up to date, only single patients show a significant therapeutic benefit as deduced from single long-term survivors. Non-invasive imaging by PET for the identification of viable target tissue and for assessment of transduction efficiency shall help to identify patients which might benefit from gene therapy, while non-invasive follow-up on treatment responses allows early and dynamic adaptations of treatment options. Therefore, molecular imaging has a critical impact on the development of standardised gene therapy protocols and on efficient and safe vector applications in humans.

Keywords

Positron Emission Tomography Gene Therapy Herpes Simplex Virus Type Thymidine Kinase Meet Positron Emission Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Maria A. Rueger
    • 1
    • 2
    • 3
    • 4
    • 5
  • Alexandra Winkeler
    • 1
    • 2
    • 3
    • 4
    • 5
  • Anne V. Thomas
    • 1
    • 2
    • 3
    • 4
    • 5
  • Lutz W. Kracht
    • 1
    • 2
    • 3
    • 4
    • 5
  • Andreas H. Jacobs
    • 1
    • 2
    • 3
    • 4
    • 5
    Email author
  1. 1.Laboratory for Gene Therapy and Molecular ImagingMax-Planck Institute for Neurological ResearchGermany
  2. 2.Klaus-Joachim-Zülch-LaboratoriesMax Planck SocietyGermany
  3. 3.Faculty of Medicine of the University of CologneCenter for Molecular Medicine (CMMC)Germany
  4. 4.Departments of NeurologyUniversity of CologneGermany
  5. 5.Klinikum FuldaGermany

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