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Molecular Imaging of PET Reporter Gene Expression

  • Jung-Joon Min
  • Sanjiv S. GambhirEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 185/2)

Abstract

Multimodality molecular imaging continues to rapidly expand and is impacting many areas of biomedical research as well as patient management. Reporter-gene assays have emerged as a very general strategy for indirectly monitoring various intracellular events. Furthermore, reporter genes are being used to monitor gene/cell therapies, including the location(s), time variation, and magnitude of gene expression. This chapter reviews reporter gene technology and its major pre-clinical and clinical applications to date. The future appears quite promising for the continued expansion of the use of reporter genes in many evolving biomedically related arenas.

Keywords

Reporter Gene Herpes Simplex Virus Type Positron Emission Tomography Imaging Thymidine Kinase Internal Ribosomal Entry Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  1. 1.Department of Nuclear MedicineChonnam National University Medical SchoolJeonnamRepublic of Korea
  2. 2.Molecular Imaging Program at StanfordThe James H Clark CenterStanford

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