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Molecular Imaging of PET Reporter Gene Expression

  • Chapter
Molecular Imaging II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 185/2))

Abstract

Multimodality molecular imaging continues to rapidly expand and is impacting many areas of biomedical research as well as patient management. Reporter-gene assays have emerged as a very general strategy for indirectly monitoring various intracellular events. Furthermore, reporter genes are being used to monitor gene/cell therapies, including the location(s), time variation, and magnitude of gene expression. This chapter reviews reporter gene technology and its major pre-clinical and clinical applications to date. The future appears quite promising for the continued expansion of the use of reporter genes in many evolving biomedically related arenas.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Chonnam National University Medical School, 160 Ilsimri, Hwasun, Jeonnam, 519-809, Republic of Korea

    Jung-Joon Min

  2. Molecular Imaging Program at Stanford, The James H Clark Center, 318 Campus Drive, East Wing, 1st Floor, Stanford, CA, 94305-5427

    Sanjiv S. Gambhir

Authors
  1. Jung-Joon Min
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  2. Sanjiv S. Gambhir
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Correspondence to Sanjiv S. Gambhir .

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Editors and Affiliations

  1. Forschungsschwerpunkt Innovative Krebsdiagnostik und -therapie (E), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfhard Semmler (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020) (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020)

  2. Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts des Isar des Technischen Universität München, Ismaninger Str. 22, 81675, München, Germany

    Markus Schwaiger

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Min, JJ., Gambhir, S.S. (2008). Molecular Imaging of PET Reporter Gene Expression. In: Semmler, W., Schwaiger, M. (eds) Molecular Imaging II. Handbook of Experimental Pharmacology, vol 185/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77496-9_12

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