Skip to main content
SpringerLink
Log in
Book cover

Radiation Oncology pp 61–72Cite as

Major Salivary Gland Tumors

  • Chapter

  • 2003 Accesses

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Malignancies of the parotid, submandibular, and sublingual glands account for approximately 4% of all head and neck cancers. A total of 80% of malignant major salivary gland tumors occur in the parotid gland. In adults, roughly a quarter of parotid tumors and one half of submandibular tumors are malignant.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990) Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy. Arch Otolaryngol Head Neck Surg 116:290–293

    PubMed  CAS  Google Scholar 

  • Beitler JJ, Smith RV, Brook A, Edelman M, Sharma A, Serrano M, Silver CE, Davis LW (1999) Benign parotid hypertrophy on +HIV patients: limited late failures after external radiation. Int J Radiat Oncol Biol Phys 45:451–455

    PubMed  CAS  Google Scholar 

  • Bhattacharyya N, Fried MP (2005) Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol 26:39–44

    Article  PubMed  Google Scholar 

  • Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE (2001) Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25:835–845

    Article  PubMed  CAS  Google Scholar 

  • Cajulis RS, Gokaslan ST, Yu GH, Frias-Hidvegi D (1997) Fine needle aspiration biopsy of the salivary glands. A fiveyear experience with emphasis on diagnostic pitfalls. Acta Cytol 41:1412–1420

    PubMed  CAS  Google Scholar 

  • Cesinaro AM, Criscuolo M, Collina G, Galetti R, Migaldi M, Lo Bianco F (1994) Salivary gland tumors: revision of 391 cases according to the new WHO classification. Pathologica 86:602–605

    PubMed  CAS  Google Scholar 

  • Chen AM, Garcia J, Lee NY, Bucci MK, Eisele DW (2007a) Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation? Int J Radiat Oncol Biol Phys 67:988–994

    PubMed  Google Scholar 

  • Chen AM, Grekin RC, Garcia J, Bucci MK, Margolis LW (2007b) Radiation therapy for cutaneous squamous cell carcinoma involving the parotid area lymph nodes: dose and volume considerations. Int J Radiat Oncol Biol Phys 69:1377–1380

    PubMed  Google Scholar 

  • Corlette TH, Cole IE, Albsoul N, Ayyash M (2005) Neck dissection of level IIb: is it really necessary? Laryngoscope 115:1624–1626

    Article  PubMed  Google Scholar 

  • Das DK, Petkar MA, Al-Mane NM, Sheikh ZA, Mallik MK, Anim JT (2004) Role of fine needle aspiration cytology in the diagnosis of swellings in the salivary gland regions: a study of 712 cases. Med Princ Pract 13:95–106

    Article  PubMed  Google Scholar 

  • Davies L, Welch HG (2006) Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg 135:451–457

    Article  PubMed  Google Scholar 

  • Douglas JG, Koh WJ, Austin-Seymour M, Laramore GE (2003) Treatment of salivary gland neoplasms with fast neutron radiotherapy. Arch Otolaryngol Head Neck Surg 129:944–948

    Article  PubMed  Google Scholar 

  • Dulguerov P, Marchal F, Lehmann W (1999) Postparotidectomy facial nerve paralysis: possible etiologic factors and results with routine facial nerve monitoring. Laryngoscope 109:754–762

    Article  PubMed  CAS  Google Scholar 

  • Fee WE Jr, Tran LE (2003) Evaluation of a patient with a parotid tumor. Arch Otolaryngol Head Neck Surg 129:937–938

    Article  PubMed  Google Scholar 

  • Frankenthaler RA, Luna MA, Lee SS, Ang KK, Byers RM, Guillamondegui OM, Wolf P, Goepfert H (1991) Prognostic variables in parotid gland cancer. Arch Otolaryngol Head Neck Surg 117: 1251–1256

    PubMed  CAS  Google Scholar 

  • Greene F, Page D, Fleming I et al. (2002) AJCC Cancer Staging Manual, 6th edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E (2006) Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope 116:534–540

    Article  PubMed  Google Scholar 

  • Hall P, Holm LE, Lundell G, Bjelkengren G, Larsson LG, Lindberg S, Tennvall J, Wicklund H, Boice JD Jr (1991) Cancer risks in thyroid cancer patients. Br J Cancer 64:159–163

    PubMed  CAS  Google Scholar 

  • Hughes JH, Volk EE, Wilbur DC (2005) Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 129:26–31

    PubMed  Google Scholar 

  • Jeong HS, Chung MK, Son YI, Choi JY, Kim HJ, Ko YH, Baek CH (2007) Role of 18F-FDG PET-CT in management of high-grade salivary gland malignancies. J Nucl Med 48:1237–1244

    Article  PubMed  Google Scholar 

  • Koh WJ, Laramore G, Griffin T, Russell K, Griffin B, Parker R, Davis L, Pajak TF (1989) Fast neutron radiation for inoperable and recurrent salivary gland cancers. Am J Clin Oncol 12:316–319

    Article  PubMed  CAS  Google Scholar 

  • Koul R, Dubey A, Butler J, Cooke AL, Abdoh A, Nason R (2007) Prognostic factors depicting disease-specific survival in parotid-gland tumors. Int J Radiat Oncol Biol Phys 68:714–718

    PubMed  Google Scholar 

  • Land CE, Saku T, Hayashi Y, Takahara O, Matsuura H, Tokuoka S, Tokunaga M, Mabuchi K (1996) Incidence of salivary gland tumors among atomic bomb survivors, 1950–1987. Evaluation of radiation-related risk. Radiat Res 146:28–36

    Article  PubMed  CAS  Google Scholar 

  • Lanier AP, Blot WJ, Bender TR, Fraumeni JF Jr (1980) Cancer in Alaskan Indians, Eskimos, and Aleuts. J Natl Cancer Inst 65:1157–1159

    PubMed  CAS  Google Scholar 

  • Martin VT, Salmaso R, Onnis GL (1989) Tumors of salivary glands. Review of 479 cases with particular reference to histological types, site, age and sex distribution. Appl Pathol 7:154–160

    PubMed  CAS  Google Scholar 

  • Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB (2005) Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer 103:2544–2550

    Article  PubMed  Google Scholar 

  • Roh JL, Ryu CH, Choi SH, Kim JS, Lee JH, Cho KJ, Nam SY, Kim SY (2007) Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med 48:240–246

    PubMed  Google Scholar 

  • Rubin P, Hansen JT (2008) TNM staging atlas. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Saku T, Hayashi Y, Takahara O, Matsuura H, Tokunaga M, Tokunaga M, Tokuoka S, Soda M, Mabuchi K, Land CE (1997) Salivary gland tumors among atomic bomb survivors, 1950–1987. Cancer 79:1465–1475

    Article  PubMed  CAS  Google Scholar 

  • Seifert G, Sobin LH (1992) The World Health Organization’s histological classification of salivary gland tumors. A commentary on the second edition. Cancer 70:379–385

    Article  PubMed  CAS  Google Scholar 

  • Stanley HR, Dawe CJ, Law LW (1964) Oral tumors induced by polyoma virus in mice. Oral Surg Oral Med Oral Pathol 17:547–558

    Article  PubMed  CAS  Google Scholar 

  • Sun EC, Curtis R, Melbye M, Goedert JJ (1999) Salivary gland cancer in the United States. Cancer Epidemiol Biomarkers Prev 8:1095–1100

    PubMed  CAS  Google Scholar 

  • Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, Tjho-Heslinga RE, de Jong JM, Roodenburg JL (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 26:681–692; discussion 692–683

    Article  PubMed  Google Scholar 

  • Theriault C, Fitzpatrick PJ (1986) Malignant parotid tumors. Prognostic factors and optimum treatment. Am J Clin Oncol 9: 510–516

    Article  PubMed  CAS  Google Scholar 

  • Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA (2007) High-risk human papillomavirus (HPV) in parotid lesions. Int J Biol Markers 22:239–244

    PubMed  CAS  Google Scholar 

  • Westra WH (2007) Diagnostic difficulties in the classification and grading of salivary gland tumors. Int J Radiat Oncol Biol Phys 69:S49–S51

    PubMed  Google Scholar 

  • Yaparpalvi R, Fontenla DP, Tyerech SK, Boselli LR, Beitler JJ (1998) Parotid gland tumors: a comparison of postoperative radiotherapy techniques using three dimensional (3D) dose distributions and dose-volume histograms (DVHS). Int J Radiat Oncol Biol Phys 40:43–49

    Article  PubMed  CAS  Google Scholar 

  • Ying YL, Johnson JT, Myers EN (2006) Squamous cell carcinoma of the parotid gland. Head Neck 28:626–632

    Article  PubMed  Google Scholar 

  • Zbaren P, Schupbach J, Nuyens M, Stauffer E (2005) Elective neck dissection versus observation in primary parotid carcinoma. Otolaryngol Head Neck Surg 132:387–391

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Radiation Oncology and Otolaryngology, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA, 30322-1013, USA

    Jonathan J. Beitler MD, MBA, FACR

  2. Emory University School of Medicine, 1365A Clifton Road NE, Atlanta, GA, 30322-1013, USA

    Amy Y. Chen MD, MPH & Charles L. Perkins MD, PhD

Authors
  1. Jonathan J. Beitler MD, MBA, FACR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amy Y. Chen MD, MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles L. Perkins MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology National University Cancer Institute of Singapore National University Health System, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  2. Department of Radiation Oncology, Cancer Hospital of Fudan University, 270 Dong An Road, Shanghai, 200232, P.R. China

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  3. College of Medicine, Drexel University, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Beitler, J.J., Chen, A.Y., Perkins, C.L. (2008). Major Salivary Gland Tumors. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77385-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77384-9

  • Online ISBN: 978-3-540-77385-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation