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Adult Gliomas

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Book cover Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Malignant or high-grade gliomas account for approximately half of all primary brain tumors in adults. Malignant gliomas include anaplastic gliomas which are classified as WHO Grade III, and glioblastoma multiforme (GBM) which is classified as WHO Grade IV. GBM accounts for about 75% of high-grade gliomas in adults, and anaplastic gliomas account for the remaining 25% of highgrade gliomas. Surgery, radiation therapy, and chemotherapy are important therapeutic modalities in the curative treatment of high-grade gliomas.

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References

  • Abrey LE, Louis DN, Paleologos N et al. (2007) Survey of treatment recommendations for anaplastic oligodendroglioma. Neuro-Oncology 9:314–318

    Article  PubMed  CAS  Google Scholar 

  • American Joint Committee on Cancer (AJCC) (1997) Cancer staging manual, 5th edn. Lippincott-Raven, Philadelphia, PA

    Google Scholar 

  • Barani IG, Benedict SH, Peck-Sun L (2007a) Neural stem cells: implications for the conventional radiotherapy of central nervous system malignancies. Int J Radiat Oncol Biol Phys 68:324–333

    PubMed  Google Scholar 

  • Barani IG, Cuttino LW, Bendict SH et al. (2007b) Neural stem cell-preserving external-beam radiotherapy of central nervous system malignancies. Int J Radiat Oncol Biol Phys 68:978–985

    PubMed  Google Scholar 

  • Barth RF, Joensuu H (2007) Boron neutron capture therapy for the treatment of glioblastomas and extracranial tumours: as effective, more effective or less effective than photon irradiation? Radiother Oncol 82:119–122

    Article  PubMed  Google Scholar 

  • Bauman GS, Gasper LE, Fischer BJ et al. (1994) A prospective study of short course radiotherapy in poor prognosis glioblastoma multiforme. Int J Radiat Oncol Biol Phys 29:835–839

    PubMed  CAS  Google Scholar 

  • Bell D, Chitnavis BP, Al-Sarraj S et al. (2004) Pilocytic astrocytoma of the adult — clinical features, radiological features and management. Br J Neurosurg 18:613–616

    Article  PubMed  CAS  Google Scholar 

  • Berger MS, Deliganis AV, Dobbins J et al. (1994) The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas. Cancer 74:1784–1791

    Article  PubMed  CAS  Google Scholar 

  • Bleehen NM, Stenning SP (1991) A Medical Research Council trial of two radiotherapy doses in the treatment of Grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party. Br J Cancer 64:769–774

    PubMed  CAS  Google Scholar 

  • Brown PD, Buckner JC, O’Fallon JR et al. (2004) Adult patients with supratentorial pilocytic astrocytomas: a prospective multicenter clinical trial. Int J Radiat Oncol Biol Phys 58:1153–1160

    PubMed  Google Scholar 

  • Cairncross JG, Macdonald DR, Ramsay DA (1992) Aggressive oligodendroglioma: a chemosensitive tumor. Neurosurgery 31:78–82

    Article  PubMed  CAS  Google Scholar 

  • Cairncross G, Berkey B, Shaw E et al. (2006) Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup RadiationTherapy Oncology Group Trial 9402. J Clin Oncol 24:2707–2714

    Article  PubMed  CAS  Google Scholar 

  • Cardinale R, Won M, Choucair A et al. (2006) A Phase II trial of accelerated radiotherapy using weekly stereotactic conformal boost for supratentorial glioblastoma multiforme: RTOG 0023. Int J Radiat Oncol Biol Phys 65:1422–1428

    PubMed  Google Scholar 

  • Castro JR, Saunders WM, Austin-Seymour MM et al. (1985) A Phase I–II trial of heavy charged particle irradiation of malignant glioma of the brain: a Northern California Oncology Group Study. Int J Radiat Oncol Biol Phys 11:1795–1800

    PubMed  CAS  Google Scholar 

  • Chakravarti A, Berkey B, Robins HI et al. (2006) An update of Phase II results from RTOG 0211: a Phase I/II study of gefitinib with radiotherapy in newly diagnosed glioblastoma. J Clin Oncol 24[Suppl]:1527

    Google Scholar 

  • Chan JL, Lee SW, Fraass BA et al. (2002) Survival and failure patterns of high grade gliomas after three-dimensional conformal radiotherapy. J Clin Oncol 20:1635–1642

    Article  PubMed  Google Scholar 

  • Chang SM, Theodosopoulos P, Lamborn K et al. (2004) Temozolamide in the treatment of recurrent malignant glioma. Cancer 100:605–611

    Article  PubMed  CAS  Google Scholar 

  • Chinot OL, Honore S, Dufour H et al. (2001) Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. J Clin Oncol 19:2449–2455

    PubMed  CAS  Google Scholar 

  • Chinot OL, Barrie M, Frauger E et al. (2004) Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer 100:2208–2214

    Article  PubMed  CAS  Google Scholar 

  • Claus EB, Horlacher A, Hsu L et al. (2005) Survival rates in patients with low grade glioma after intraoperative magnetic resonance image guidance. Cancer 103:1227–1233

    Article  PubMed  Google Scholar 

  • Colman H, Berkey BA, Moar MH et al. (2006) Phase II Radiation Therapy Oncology Group trial of conventional radiation therapy followed by treatment with recombinant interferon-beta for supratentorial glioblastoma: results of RTOG 9710. Int J Radiat Oncol Biol Phys 66:818–824

    PubMed  CAS  Google Scholar 

  • Curran WJ Jr, Scott CB, Horton J et al. (1993) Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 85:704–710

    Article  PubMed  Google Scholar 

  • Curran W, Scott C, Yung W et al. (1996) No survival benefit of hyperfractionated radiotherapy (RT) to 72.0 Gy and carmustine versus standard RT and carmustine for malignant glioma patients: preliminary results of RTOG 90-06. J Clin Oncol 15[Suppl]:154, 280

    Google Scholar 

  • DelRowe J, Scott C, Werner-Wasik M et al. (2000) A singlearm open label Phase II study of intravenously administered tirapazamine plus radiation therapy for glioblastoma multiforme. J Clin Oncol 18:1254–1259

    CAS  Google Scholar 

  • Donahue B, Scott C, Nelson J et al. (1997) Influence of an oligodendroglial component on the survival of patients with anaplastic astrocytoma: a report of RTOG 83-02. Int J Radiat Oncol Biol Phys 38:911–914

    PubMed  CAS  Google Scholar 

  • Dyke JO, Sanelli PC, Voss HU et al. (2007) Monitoring the effects of BCNU chemotherapy wafers (Gliadel) in glioblastoma multiforme with proton magnetic resonance spectroscopic imaging at 3.0 Tesla. J Neurooncol 82:103–110

    Article  PubMed  CAS  Google Scholar 

  • Eyre HJ, Crowley J, Townsend JJ et al. (1993) A randomized trial of radiotherapy versus radiotherapy plus CCNU for incompletely resected low-grade gliomas. A SWOG study. J Neurosurg 78:909–914

    PubMed  CAS  Google Scholar 

  • Fallon KB, Palmer CA, Roth KA et al. (2004) Prognostic value of 1 p, 19 q, 9 p, 10 q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol 63:314–322

    PubMed  CAS  Google Scholar 

  • Fisher B, Won M, Macdonald D et al. (2002) Phase II study of topotecan plus cranial radiation for glioblastoma multiforme: results of Radiation Therapy Oncology Group RTOG 95-13. Int J Radiat Onco Biol Phys 53:980–986

    Article  CAS  Google Scholar 

  • Ford JM, Stenning SP, Boote DJ et al. (1997) A short fractionation radiotherapy for poor prognosis patients with high-grade glioma. Clin Oncol 9:20–24

    Article  CAS  Google Scholar 

  • Ford JM, Seiferheld W, Alger JR et al. (2007) Results of the Phase I dose-escalating study of motexafin gadolinium with standard radiotherapy in patients with glioblastoma multiforme. Int J Radiat Oncol Biol Phys 69:831–838

    PubMed  CAS  Google Scholar 

  • Gajjar A, Bhargava R, Jenkins JJ et al. (1995) Low-grade astrocytoma with neuraxis dissemination at diagnosis. J Neurosurg 83:67–71

    PubMed  CAS  Google Scholar 

  • Hegi ME, Diserens AC, Gorlia T et al. (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997–1003

    Article  PubMed  CAS  Google Scholar 

  • Herholz K, Coope D, Jackson A (2007) Metabolic and molecular imaging in neuro-oncology. Lancet Neurol 6:711–724

    Article  PubMed  CAS  Google Scholar 

  • Hess CF, Schaaf JC, Kortmann RD et al. (1994) Malignant glioma: patterns of failure following individually tailored limited volume irradiation. Radiother Oncol 30:146–149

    Article  PubMed  CAS  Google Scholar 

  • Hess KR, Wong ET, Jaeckle KA et al. (1999) Response and progression in recurrent malignant glioma. Neuro Oncol 1:282–288

    Article  PubMed  CAS  Google Scholar 

  • Hochberg FH, Pruitt A (1980) Assumptions in the radiotherapy of glioblastoma. Neurology 30:907–911

    PubMed  CAS  Google Scholar 

  • Hukin J, Siffert J, Cohen H et al. (2003) Leptomeningeal dissemination at diagnosis of pediatric low-grade neuroepithelial tumors. Neuro Oncol 5:188–196

    Article  PubMed  Google Scholar 

  • Jackson RJ, Fuller GN, Abi-Said D et al. (2001) Limitations of stereotactic biopsy in the initial management of gliomas. Neuro Oncol 3:193–200

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson MD, Du Plessis DG, Walker C, Smith TS (2007) Advanced MRI in the management of adult gliomas. Br J Neurosurg 21:550–561

    Article  PubMed  CAS  Google Scholar 

  • Jeon YK, Park K, Park CK et al. (2007) Chromosome 1 p and 19 q status and p 53 and p 16 expression patterns as prognostic indicators of oligodendroglial tumors: a clinicopathological study using fluorescence in situ hybridization. Neuropathology 27:10–20

    Article  PubMed  Google Scholar 

  • Karim AB, Maat B, Hatlevoll R et al. (1996) A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. Int J Radiat Oncol Biol Phys 36:549–556

    PubMed  CAS  Google Scholar 

  • Kelly PJ, Daumas-Duport C, Scheithauer BW et al. (1987) Stereotactic histologic correlations of computed tomography-and magnetic resonance imaging-defined abnormalities in patients with glial neoplasms. Mayo Clin Proc 62:450–459

    PubMed  CAS  Google Scholar 

  • Kreth FW, Faist M, Rossner R et al. (1997) Supratentorial World Health Organization Grade 2 astrocytomas and oligodendrogliomas. A new pattern of prognostic factors. Cancer 70:370–379

    Article  Google Scholar 

  • Krishnan S, Brown PD, Ballman KV et al. (2006) Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Center Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys 65:1192–1199

    PubMed  CAS  Google Scholar 

  • Langer C, Ruffer J, Rhodes H et al.(2001) Phase II Radiation Therapy Oncology Group Trial of weekly paclitaxel and conventional external beam radiation therapy for supratentorial glioblastoma multiforme. Int J Radiat Oncol Biol Phys 51:113–119

    PubMed  CAS  Google Scholar 

  • Laramore GE, Diener-West M, Griffin TW et al. (1988) Randomized neutron dose searching study for malignant gliomas of the brain: results of an RTOG study. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 14:1093–1102

    PubMed  CAS  Google Scholar 

  • Laws ER, Parney IF, Huang W et al. (2003) Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes project. J Neurosurg 99:467–473

    PubMed  Google Scholar 

  • Leighton C, Fisher B, Bauman G et al. (1997) Supratentorial low-grade glioma in adults: an analysis of prognostic factors and timing of radiation. J Clin Oncol 15:1294–1301

    PubMed  CAS  Google Scholar 

  • Levin VA, Silver P, Hannigan J et al. (1990) Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 18:321–324

    PubMed  CAS  Google Scholar 

  • MacDonald S, Ahmad S, Krachis S et al. (2007) Intensity modulated radiation therapy versus three-dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison. J Appl Clin Med Phys 8:47–60

    PubMed  Google Scholar 

  • Mamelak AN, Prados MD, Obana WG et al. (1994) Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. J Neurosurg 81:24–30

    PubMed  CAS  Google Scholar 

  • Minniti G, De Sanctis V, Muni R et al. (2008) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol; published online Feb 5, 2008

    Google Scholar 

  • Miralbell R, Mornex F, Greiner R et al. (1999) Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 17:3143–3149

    PubMed  CAS  Google Scholar 

  • Mirimanoff R, Mason W, Van den Bent M et al. (2007) Is long-term survival in glioblastoma possible? Updated results of the EORTC/NCIC Phase III randomized trial on radiotherapy (RT) and concomitant and adjuvant temozolamide (TMZ) versus RT alone. Int J Radiat Oncol Biol Phys 69[Suppl]:S2

    Google Scholar 

  • Murray KJ, Nelson DF, Scott C et al. (1995) Quality-adjusted survival analysis of malignant glioma. Patients treated with twice-daily radiation (RT) and carmustine: a report of Radiation Therapy Oncology Group (RTOG) 83-02. Int J Radiat Oncol Biol Phys 31:453–459

    PubMed  CAS  Google Scholar 

  • Narayana A, Yamada J, Berry S et al. (2006) Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results. Int J Radiat Oncol Biol Phys 64:892–897

    PubMed  Google Scholar 

  • Narayana A, Chang J, Thakur S et al. (2007a) Use of MR spectroscopy and functional imaging in the treatment planning of gliomas. Br J Radiol 80:347–354

    Article  PubMed  CAS  Google Scholar 

  • Narayana A, Golfinos J, Knopp E et al. (2007b) Feasibility of using bevacizumab with radiation therapy in high grade glioma. Int J Radiat Oncol Biol Phys 69[Suppl]:90,S51

    Google Scholar 

  • Nelson DF, Diener-West M, Weinstein AS et al. (1986) A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery: final report of an RTOG study. Int J Radiat Oncol Biol Phys 12:1793–1800

    PubMed  CAS  Google Scholar 

  • Nelson DF, Diener-West M, Horton J et al. (1988) Combined modality approach to treatment of malignant gliomas — re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: a joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group. NCI Monogr (6):279–284

    PubMed  Google Scholar 

  • Pickles T, Goodman GB, Rheaume DE et al. (1997) Pion radiation for high grade astrocytoma: results of a randomized study. Int J Radiat Oncol Biol Phys 37:491–497

    PubMed  CAS  Google Scholar 

  • Pignatti F, van den Bent M, Curran D et al. (2002) Prognostic factors for survival in adult patients with cerebral low-grade glioma. J Clin Oncol 20:2076–2084

    Article  PubMed  Google Scholar 

  • Pirzkall A, Larson DA, McKnight TR et al. (2000) MR-spectroscopy results in improved target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys 48[Suppl]:115

    Google Scholar 

  • Pollack IF, Hurtt M, Pang D et al. (1994) Dissemination of low grade intracranial astrocytomas in children. Cancer 73:2671–2673

    Article  Google Scholar 

  • Prados MD, Scott C, Curran WJ Jr et al. (1999) Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: a retrospective review of Radiation Therapy Oncology Group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. J Clin Oncol 17:3389–3395

    PubMed  CAS  Google Scholar 

  • Quang TS, Brady L (2004) Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas. Int J Radiat Onco Biol Phys 58:972–975

    Article  CAS  Google Scholar 

  • Reardon DA, Desjardins A, Rich JN, Vredenburgh JJ (2008) The emerging role of anti-angiogenic therapy for malignant glioma. Curr Treat Options Oncol; published online Feb 7, 2008

    Google Scholar 

  • Robins HI, Won M, Seiferheld WF et al. (2006) Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021. Neuro Oncol 8:47–52

    Article  PubMed  CAS  Google Scholar 

  • Sathornsumetee S, Reardon DA, Quinn JA et al. (2006) An update on Phase I study of dose-escalating imatinib mesylate plus standard-dosed temozolomide for the treatment of patients with malignant glioma. J Clin Oncol 24[Suppl]:1560

    Google Scholar 

  • Scott C, Curran W, Yung W et al. (1998) Long term results of RTOG 9006: a randomized trial of hyperfractionated radiotherapy (RT) to 72.0 Gy and carmustine vs. standard RT and carmustine for malignant glioma patients with emphasis on anaplastic astrocytoma (AA) patients. J Clin Oncol 16[Suppl]:384

    Google Scholar 

  • Selker RG, Shapiro WR, Burger P et al. (2002) The Brain Tumor Cooperative Group NIH Trial 87-01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine. Neurosurgery 51:343–355

    Article  PubMed  Google Scholar 

  • Shaw E, Arusell R, Scheithauer B et al. (2002) Prospective randomized trial of low-versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study. J Clin Oncol 20:2267–2276

    Article  PubMed  CAS  Google Scholar 

  • Shaw EG, Berkey BA, Coons SW et al. (2006) Initial report of Radiation Therapy Oncology Group (RTOG) 9802: prospective studies in adult low-grade glioma (LGG). J Clin Oncol 24[Suppl]:1500

    Google Scholar 

  • Smith JS, Perry A, Borell TJ et al. (2000) Alterations of chromosome arms 1 p and 19 q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 18:636–645

    PubMed  CAS  Google Scholar 

  • Souhami L, Seiferheld W, Brachman D et al. (2004) Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol. Int J Radiat Oncol Biol Phys 60:853–860

    PubMed  Google Scholar 

  • Stewart LA (2002) Chemotherapy in adult high grade glioma: a systematic review and metaanalysis of individual patient data from 12 randomised trials. Lancet 359:1011–1018

    Article  PubMed  CAS  Google Scholar 

  • Stuer C, Vilz B, Majores M et al. (2007) Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer 110:2799–2808

    Article  PubMed  Google Scholar 

  • Stupp R, Mason WP, Van den Bent MJ et al. (2005) Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. N Engl J Med 352:987–996

    Article  PubMed  CAS  Google Scholar 

  • Stupp R, Hegi ME, Gilbert MR and Chakravarti A (2007) Chemoradiotherapy in malignant glioma: standard of care and future directions. J Clin Oncol 25:4127–4136

    Article  PubMed  CAS  Google Scholar 

  • Tsien C, Piert M, Junck D et al. (2005) The impact of 11C methionine (11C MET) positron emission tomography (PET) imaging in target volume delineation of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 63[Suppl]:S63–S64

    Google Scholar 

  • Van den Bent MJ, Afra D, de Witte O et al. (2005) Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet 366:985–990

    Article  PubMed  Google Scholar 

  • Van den Bent MJ, Carpentier AF, Brandes AA et al. (2006) Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organization for Research and Treatment of Cancer Phase III trial. J Clin Oncol 24:2715–2722

    Article  PubMed  CAS  Google Scholar 

  • Voelzke WR, Petty WJ, Lesser GJ (2008) Targeting the epidermal growth factor receptor in high-grade astrocytomas. Curr Treat Options Oncol; published online Feb 5, 2008

    Google Scholar 

  • Vogelbaum MA, Berkey B, Peereboom D et al. (2005) RTOG 0131: Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligodendrogliomas. J Clin Oncol 23[Suppl]:1520

    Google Scholar 

  • Walker MD, Alexander E, Jr, Hunt WE et al. (1978) Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49:333–343

    Article  PubMed  CAS  Google Scholar 

  • Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5:1725–1731

    PubMed  CAS  Google Scholar 

  • Walker MD, Green SB, Byar DP et al. (1980) Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303:1323–1329

    PubMed  CAS  Google Scholar 

  • Welsh J, Sanan A, Gabayan AJ et al. (2007) GliaSite brachytherapy boost as part of initial treatment of glioblastoma multiforme: a retrospective multi-institutional pilot study. Int J Radiat Oncol Biol Phys 68:159–165

    PubMed  Google Scholar 

  • Werner-Wasik M, Scott CB, Nelson DF et al. (1996) Final report of a Phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas. Radiation Therapy Oncology Group Study 83-02. Cancer 77:1535–1543

    Article  PubMed  CAS  Google Scholar 

  • Werner-Wasik M, Seiferheld W, Michalski J et al. (2004) Phase I/II conformal three-dimensional radiation therapy dose escalation study in patients with supratentorial glioblastoma multiforme: report of the Radiation Therapy Oncology Group 98-03 Protocol. Int J Radiat Oncol Biol Phys 60[Suppl]:S163–164, 58

    Article  Google Scholar 

  • Westphal M, Hilt DC, Bortey E et al. (2003) A Phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol 5:79–88

    Article  PubMed  CAS  Google Scholar 

  • Yung WK, Prados MD, Yaya-Tur R et al. (1999) Multicenter Phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. J Clin Oncol 17:2762–2771

    PubMed  CAS  Google Scholar 

  • Yung WA, Seiferheld W, Donahue B et al. (2001) A RTOG (Radiation Therapy Oncology Group) Phase II study of conventional radiation therapy plus thalidomide followed by thalidomide post XRT for supratentorial glioblastoma. J Clin Oncol 20[Suppl]:206, 52a

    Google Scholar 

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Donahue, B.R. (2008). Adult Gliomas. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_33

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