Abstract
Cervical cancer is a malignancy occurring worldwide. In developing countries, cervical cancer can be epidemic and is higher in incidence and prevalence than in this country due to Pap smear screening. If the disease process is found early, many patients can be diagnosed with CIN and be treated without ever developing invasive cancer. As the disease progresses to invasive cancer, even advanced stages can be treated and cured.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Benedet JL, Bender H, Jones H 3rd et al. (2000) FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 70:209–262
Burghardt E, Pickel H (1978) Local spread and lymph node involvement in cervical cancer. Obstet Gynecol 52:138–145
Bush R (1986) The significance of anemia in clinical radiation therapy. Int J Radiat Oncol Biol Phys 12:2047–2050
Delgado G, Bundy BN, Fowler WC Jr et al (1989) A prospective surgical pathological study of stage I squamous carcinoma of the cervix: a Gynecologic Oncology Group Study. Gynecol Oncol 35:314–320
Eifel PJ, Winter K, Morris M et al (2004) Pelvic irradiation with concurrent chemotherapy versus pelvic and paraaortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol 22:872–880
Finlay MH, Ackerman I, Tirona RG et al (2006) Use of CT simulation for treatment of cervical cancer to assess the adequacy of lymph node coverage of conventional pelvic fields based on bony landmarks. Int J Radiat Oncol Biol Phys 64:205–209
Fyles A, Keane TJ, Barton M et al (1992) The effect of treatment duration in the local control of cervix cancer. Radiother Oncol 25:273–279
Girinski T, Pejovic-Lenfant MH, Bourhis J et al (1989) Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: results of a retrospective study of 386 patients. Int J Radiat Oncol Biol Phys 16:37–42
Grigsby PW, Siegel BA, Dehdashti F et al (2003) Posttherapy surveillance monitoring of cervical cancer by FDG-PET. Int J Radiat Oncol Biol Phys 55:907–913
Grigsby PW, Siegel BA, Dehdashti F et al (2004) Posttherapy [18F] fluorodeoxyglucose positron emission tomography in carcinoma of the cervix: response and outcome. J Clin Oncol 22:2167–2171
Grogan M, Thomas GM, Melamed I et al (1999) The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix. Cancer 86:1528–1536
Herbst AL, Cole P, Norusis MJ et al (1979) Epidemiologic aspects and factors related to survival in 384 registry cases of clear cell adenocarcinoma of the vagina and cervix. Am J Obstet Gynecol 135:876–886
International Commission of Radiation Units and Measurements (1985) Dose and volume specifications for reporting intracavitary therapy in gynecology. ICRU Report 38. International Commission on Radiation Units, Bethesda, MD
Kapp KS, Poschauko J, Geyer E et al (2002) Evaluation of the effect of routine packed red blood cell transfusion in anemic cervix cancer patients treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 54:58–66
Keys HM, Bundy BN, Stehman FB et al (1999) Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340:1154–1161
Kolstad P (1989) Follow-up study of 232 patients with stage Ia1 and 411 patients with stage Ia2 squamous cell carcinoma of the cervix (microinvasive carcinoma). Gynecol Oncol 33:265–272
Lanciano RM, Martz K, Coia LR et al (1993) Tumor and treatment factors improving outcome in stage III-B cervix cancer. Int J Radiat Oncol Biol Phys 20:95–100
Landoni F, Maneo A, Colombo A et al (1997) Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 350:535–540
Loft A, Berthelsen AK, Roed H et al (2007) The diagnostic value of PET/CT scanning in patients with cervical cancer: a prospective study. Gynecol Oncol 106:29–34
Look KY, Brunetto VL, Clarke-Pearson DL et al (1996) An analysis of cell type in patients with surgically staged stage IB carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 63:304–311
Monk BJ, Wang J, Im S et al (2005) Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical-pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial. Gynecol Oncol 96:721–728
Morris M, Eifel PJ, Lu J et al (1999) Pelvic radiation with concurrent chemotherapy compared with pelvic and paraaortic radiation for high-risk cervical cancer. N Engl J Med 340:1137–1143
Mundt AJ, Lujan AE, Rotmensch J et al (2002) Intensitymodulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 52:1330–1337
Nag S, Erickson B, Thomadsen B et al (2000) The American Brachytherapy Society recommendations for high-doserate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys 48:201–211
National Comprehensive Cancer Network (2007) Clinical practice guidelines in oncology: Cervical vancer, version 1.2008. Available at http://www.nccn.org/professionals/physician_gls/PDF/cervical.pdf. Last accessed on 8 March 2008
Patel FD, Sharma SC, Negi PS et al (1994) Low dose rate vs. high dose rate brachytherapy in the treatment of carcinoma of the uterine cervix: a clinical trial. Int J Radiat Oncol Biol Phys 28:335–341
Perez CA, Camel HM, Kuske RR et al (1986) Radiation therapy alone in the treatment of carcinoma of the uterine cervix: a 20-year experience. Gynecol Oncol 23:127–140
Perez CA, Grigsby PW, Castro-Vita H et al (1995) Carcinoma of the uterine cervix. I. Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy. Int J Radiat Oncol Biol Phys 32:1275–1288
Peters WA, Liu PY, Barrett RJ et al (2000) Concurrent chemotherapy and pelvic radiation therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18:1606–1613
Petereit DG, Sarkaria JN, Chappell R et al (1995) The adverse effect of treatment prolongation in cervical carcinoma. Int J Radiat Oncol Biol Phys 32:1301–1307
Rose PG, Bundy BN, Watkins EB et al (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144–1153
Sedlis A, Bundy BN, Rotman MZ et al (1999) A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study. Gynecol Oncol 73:177–183
Sethi TK, Bhalla NK, Jena AN et al (2005) Magnetic resonance imaging in carcinoma cervix-does it have a prognostic relevance. J Cancer Res Ther 1:103–107
Shingleton HM, Bell MC, Fremgen A et al (1995) Is there really a difference in survival of women with squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the cervix? Cancer 76(10 Suppl):1948–1955
Sironi S, Buda A, Picchio M et al (2006) Lymph node metastasis in patients with clinical early-stage cervical cancer: detection with integrated FDG PET/CT. Radiology 238:272–279
Stehman FB, Bundy BN, DiSaia PJ et al (1991) Carcinoma of the cervix treated with radiation therapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer 67:2776–2785
Stehman FB, Ali S, Keys HM et al (2007) Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial. Am J Obstet Gynecol 197:503. e1–6
Takeda N, Sakuragi N, Takeda M et al (2002) Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy. Acta Obstet Gynecol Scand 81:1144–1151
Teshima T, Inoue T, Ikeda H et al (1993) High-dose rate and low-dose rate intracavitary therapy for carcinoma of the uterine cervix. Final results of Osaka University Hospital. Cancer 72:2409–2414
Wagenaar HC, Trimbos JB, Postema S et al (2001) Tumor diameter and volume assessed by magnetic resonance imaging in the prediction of outcome for invasive cervical cancer. Gynecol Oncol 82:474–482
Whitney CW, Sause W, Bundy BN et al (1999) Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIBIVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17:1339–1348
Withers HR, Taylor JM, Maciejewski B (1988) The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27:131–146
Wolfson AH, Abdel-Wahab M, Markoe AM et al (1997) A quantitative assessment of standard versus customized midline shield construction for invasive cervical carcinoma. Int J Radiat Oncol Biol Phys 37:237–242
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mutyala, S., Wolfson, A.H. (2008). Cervical Cancer. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_24
Download citation
DOI: https://doi.org/10.1007/978-3-540-77385-6_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-77384-9
Online ISBN: 978-3-540-77385-6
eBook Packages: MedicineMedicine (R0)