Abstract
Endometrial cancer is the most common gynecological cancer in the United States, and its incidence is expected to rise worldwide. Approximately 70%–80% of patients with endometrial cancer present with FIGO stage I disease confined to the uterus. Surgery is the mainstay of evaluation for risk of extra-uterine spread as well as definitive treatment. Multidisciplinary management, including radiation therapy, plays an important role as adjuvant treatment for patients with high risk of recurrence determined by surgical-pathological staging. In addition, patients who are medically or surgically inoperable can also be treated with radiotherapy with either radical or palliative intent.
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References
Aalders J, Abeler V, Kolstad P et al (1980) Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 56:419–427
Alektiar KM, Venkatraman E, Chi DS et al. (2005) Intravaginal brachytherapy alone for intermediate-risk endometrial cancer. Int J Radiat Oncol Biol Phys 62:111–117
Ayhan A, Taskiran C, Celik C et al (2004) The long-term survival of women with surgical stage II endometrioid type endometrial cancer. Gynecol Oncol 93:9–13
Brixey CJ, Roeske JC, Lujan AE et al (2002) Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 54:1388–1396
Briët JM, Hollema H, Reesink N et al (2005) Lymphvascular space involvement: an independent prognostic factor in endometrial cancer. Gynecol Oncol 96:799–804
Creasman WT, Morrow CP, Bundy BN et al (1987) Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 60[8 Suppl]:2035–2041
Creutzberg CL, van Putten WL, Koper PC et al (2000) Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 355:1404–1411
Creutzberg CL, van Putten WL, Koper PC et al (2003) Survival after relapse in patients with endometrial cancer: results from a randomized trial. Gynecol Oncol 89:201–209
Dore R, Moro G, D’Andrea F et al (1987) CT evaluation of myometrium invasion in endometrial carcinoma. J Comput Assist Tomogr 11:282–289
Eltabbakh GH, Piver MS, Hempling RE et al (1997) Excellent long-term survival and absence of vaginal recurrences in 332 patients with low-risk stage I endometrial adenocarcinoma treated with hysterectomy and vaginal brachytherapy without formal staging lymph node sampling: report of a prospective trial. Int J Radiat Oncol Biol Phys 38:373–380
Feltmate CM, Duska LR, Chang Y et al (1999) Predictors of recurrence in surgical stage II endometrial adenocarcinoma. Gynecol Oncol 73:407–411
Fishman DA, Roberts KB, Chambers JT et al (1996) Radiation therapy as exclusive treatment for medically inoperable patients with stage I and II endometrioid carcinoma with endometrium. Gynecol Oncol 61:189–196
Fleming GF, Filiaci VL, Bentley RC et al (2004) Phase III randomized trial of doxorubicin + cisplatin versus doxorubicin + 24-h paclitaxel + filgrastim in endometrial carcinoma: a Gynecologic Oncology Group study. Ann Oncol 15:1173–1178
Gerszten K, Faul C, Kounelis S et al (1998) The impact of adjuvant radiotherapy on carcinosarcoma of the uterus. Gynecol Oncol 68:8–13
Giuntoli RL 2nd, Metzinger DS, DiMarco CS et al (2003) Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy. Gynecol Oncol 89:460–469
Greven KM, Lanciano RM, Corn B et al (1993) Pathologic stage III endometrial carcinoma. Prognostic factors and patterns of recurrence. Cancer 71:3697–3702
Greven KM, Corn BW, Case D et al (1997) Which prognostic factors influence the outcome of patients with surgically staged endometrial cancer treated with adjuvant radiation? Int J Radiat Oncol Biol Phys 39:413–418
Grigsby PW, Perez CA, Kuske RR et al (1987) Results of therapy, analysis of failures, and prognostic factors for clinical and pathologic stage III adenocarcinoma of the endometrium. Gynecol Oncol 27:44–57
Heron DE, Gerszten K, Selvaraj RN et al (2003) Conventional 3D conformal versus intensity-modulated radiotherapy for the adjuvant treatment of gynecologic malignancies: a comparative dosimetric study of dose-volume histograms. Gynecol Oncol 91:39–45
Hornback NB, Omura G, Major FJ (1986) Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. Int J Radiat Oncol Biol Phys 12:2127–2130
Horowitz NS, Peters WA 3rd, Smith MR et al (2002) Adjuvant high dose rate vaginal brachytherapy as treatment of stage I and II endometrial carcinoma. Obstet Gynecol 99:235–240
Kadar N, Homesley HD, Malfetano JH (1992) Positive peritoneal cytology is an adverse factor in endometrial carcinoma only if there is other evidence of extrauterine disease. Gynecol Oncol 46:145–149
Kauppila A (1989) Oestrogen and progestin receptors as prognostic indicators in endometrial cancer. A review of the literature. Acta Oncol 28:561–566
Kasamatsu T, Onda T, Katsumata N et al (2003) Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus. Br J Cancer 88:245–250
Karlsson B, Granberg S, Wikland M et al (1995) Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding-a Nordic multicenter study. Am J Obstet Gynecol 172:1488–1494
Keys HM, Roberts JA, Brunetto VL et al. (2004) A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92:744–751
Kilgore LC, Partridge EE, Alvarez RD et al (1995) Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol 56:29–33
Lanciano RM, Curran WJ Jr, Greven KM et al (1990) Influence of grade, histologic subtype, and timing of radiotherapy on outcome among patients with stage II carcinoma of the endometrium. Gynecol Oncol 39:368–373
Larson B, Silfverswärd C, Nilsson B et al (1990a) Endometrial stromal sarcoma of the uterus. A clinical and histopathological study. The Radiumhemmet series 1936–1981. Eur J Obstet Gynecol Reprod Biol 35:239–249
Larson B, Silfverswärd C, Nilsson B et al (1990b) Mixed mullerian tumours of the uterus-prognostic factors: a clinical and histopathologic study of 147 cases. Radiother Oncol 17:123–132
Lee CM, Szabo A, Shrieve DC et al. (2006) Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinoma. JAMA 295:389–397
Lujan AE, Mundt AJ, Yamada SD et al (2003) Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. Int J Radiat Oncol Biol Phys 57:516–521
Manfredi R, Mirk P, Maresca G et al (2004) Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 231:372–378
Mariani A, Webb MJ, Galli L et al (2000a) Potential therapeutic role of para-aortic lymphadenectomy in node-positive endometrial cancer. Gynecol Oncol 76:348–356
Mariani A, Webb MJ, Keeney GL et al (2000b) Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol 182:1506–1519
Mariani A, Webb MJ, Keeney GL et al (2002) Assessment of prognostic factors in stage IIIA endometrial cancer. Gynecol Oncol 86:38–44
Martin-Hirsch PL, Lilford RJ, Jarvis GJ (1996) Adjuvant progestagen therapy for the treatment of endometrial cancer: review and meta-analyses of published randomised controlled trials. Eur J Obstet Gynecol Reprod Biol 65:201–207
Martin-Hirsch PL, Jarvis G, Kitchener H et al (2000) Progestagens for endometrial cancer. Cochrane Database Syst Rev 2000(2):CD001040
Morrow CP, Bundy BN, Homesley HD et al (1990) Doxorubicin as an adjuvant following surgery and radiation therapy in patients with high-risk endometrial carcinoma, stage I and occult stage II: a Gynecologic Oncology Group Study. Gynecol Oncol 36:166–171
Morrow CP, Bundy BN, Kurman RJ et al (1991) Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 40:55–65
Mundt AJ, Lujan AE, Rotmensch J et al (2002) Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 52:1330–1337
Mundt AJ, Mell LK, Roeske JC (2003) Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy. Int J Radiat Oncol Biol Phys 56:1354–1360
Pitson G, Colgan T, Levin W et al (2002) Stage II endometrial carcinoma: prognostic factors and risk classification in 170 patients. Int J Radiat Oncol Biol Phys 53:862–867
Podratz KC, Mariani A, Webb MJ (1998) Staging and therapeutic value of lymphadenectomy in endometrial cancer. Gynecol Oncol 70:163–164
Poulsen MG, Roberts SJ (1988) The salvage of recurrent endometrial carcinoma in the vagina and pelvis. Int J Radiat Oncol Biol Phys 15:809–813
Randall ME, Filiaci VL, Muss H et al (2006) Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 24:36–44
Sartori E, Gadducci A, Landoni F et al (2001) Clinical behavior of 203 stage II endometrial cancer cases: the impact of primary surgical approach and of adjuvant radiation therapy. Int J Gynecol Cancer 11:430–437
Schorge JO, Molpus KL, Goodman A et al (1996) The effect of postsurgical therapy on stage III endometrial carcinoma. Gynecol Oncol 63:34–39
Suzuki C, Matsumoto T, Sonoue H et al (2003) Prognostic significance of the infiltrative pattern invasion in endometrioid adenocarcinoma of the endometrium. Pathol Int 53:495–500
Tebeu PM, Popowski Y, Verkooijen HM et al (2004) Positive peritoneal cytology in early-stage endometrial cancer does not inf luence prognosis. Br J Cancer 91:720–724
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Lee, K.M. (2008). Endometrial Cancer. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_23
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DOI: https://doi.org/10.1007/978-3-540-77385-6_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-77384-9
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