Skip to main content

Pancreatic Cancer

  • Chapter
  • 1969 Accesses

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Pancreatic cancer is a challenging disease to treat.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abrams RA, Winter KA, Regine WF et al. (2007) Correlation of RTOG 9704 (adjuvant therapy of pancreatic adenocarcinoma radiation therapy quality assurance scores with survival. J Clin Oncol 25[18S]:4523

    Google Scholar 

  • Bakkevold KE, Arnesjø B, Dahl O et al. (1993) Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater — results of a controlled, prospective, randomised multicentre study. Eur J Cancer 29A:698–703

    Article  PubMed  CAS  Google Scholar 

  • Ben-Josef E, Shields AF, Vaishampayan U et al. (2004) Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer. Int J Radiat Oncol Biol Phys 59:454–459

    PubMed  CAS  Google Scholar 

  • Birkmeyer JD, Siewers AE, Finlayson EV et al. (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137

    Article  PubMed  Google Scholar 

  • Brown MW, Ning H, Arora B et al. (2006) A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma. Int J Radiat Oncol Biol Phys 65:274–283

    PubMed  Google Scholar 

  • Burris HA 3rd, Moore MJ, Andersen J et al. (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403–2413

    PubMed  CAS  Google Scholar 

  • Chauffert B, Mornex F, Bonnetain F et al. (2006) Phase III trial comparing initial chemoradiotherapy (intermittent cisplatin and infusional 5-FU) followed by gemcitabine vs. gemcitabine alone in patients with locally advanced non metastatic pancreatic cancer: A FFCD-SFRO study. J Clin Oncol 24[18S, Part I]:4008

    Google Scholar 

  • Greene F, Page D, Fleming I et al. (2002) AJCC Cancer Staging Manual, 6th edn. Springer-Verlag, Berlin Heidelberg New York

    Google Scholar 

  • Kalser MH, Ellenberg SS (1985) Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120:899–903

    PubMed  CAS  Google Scholar 

  • Klinkenbijl JH, Jeekel J, Sahmoud T et al. (1999) Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230:776–784

    Article  PubMed  CAS  Google Scholar 

  • Landry JC, Yang GY, Ting JY et al. (2002) Treatment of pancreatic cancer tumors with intensity-modulated radiation therapy (IMRT) using the volume at risk approach (VARA): employing dose-volume histogram (DVH) and normal tissue complication probability (NTCP) to evaluate small bowel toxicity. Med Dosim 27:121–129

    Article  PubMed  Google Scholar 

  • Louvet C, Hincke A, Labianca R et al. (2006) Increased survival using platinum analog combined with gemcitabine as compared to gemcitabine single agent in advanced pancreatic cancer (APC): pooled analysis of two randomised trials, the GERCOR/GISCAD Intergroup Study and a German Multicenter Study. J Clin Oncol 24[18S, Part I]:4003

    Google Scholar 

  • Mertz HR, Sechopoulos P, Delbeke D et al. (2000) EUS, PET, and CT scanning for evaluation of pancreatic adenocarcinoma. Gastrointest Endosc 52:367–371

    Article  PubMed  CAS  Google Scholar 

  • Milano MT, Chmura SJ, Garofalo MC et al. (2004) Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 59:445–53

    PubMed  Google Scholar 

  • Miura F, Takada T, Amano H et al (2006) Diagnosis of pancreatic cancer. HPB (Oxford) 8:337–342

    Google Scholar 

  • Moertel CG, Frytak S, Hahn RG et al. (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group. Cancer 48:1705–1710

    Article  PubMed  CAS  Google Scholar 

  • Moutardier V, Turrini O, Huiart L et al. (2004) A reappraisal of preoperative chemoradiation for localized pancreatic head ductal adenocarcinoma in a 5-year single-institution experience. J Gastrointest Surg 8:502–510

    Article  PubMed  CAS  Google Scholar 

  • National Comprehensive Cancer Network (2008) Clinical practice guidelines in oncology: pancreatic adenocarcinoma. Version I.2008. Available at http://nccn.org/professionals/physician_gls/PDF/rectal.pdf. Accessed on March 26, 2008

    Google Scholar 

  • Neoptolemos JP, Dunn JA, Stocken DD et al. (2001) Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. Lancet 358:1576–1585

    Article  PubMed  CAS  Google Scholar 

  • Neoptolemos JP, Stocken DD, Friess H et al. (2004) A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200–1210

    Article  PubMed  CAS  Google Scholar 

  • Oettle H, Post S, Neuhaus P et al. (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 297:267–277

    Article  PubMed  CAS  Google Scholar 

  • Picozzi VJ, Kozarek RA, Traverso LW (2003) Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am J Surg 285:476–480

    Article  Google Scholar 

  • Regine WF, Winter KW, Abrams R et al. (2006) RTOG 9704 a phase III study of adjuvant pre and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma. J Clin Oncol 24[18S, Part I]:4007

    Google Scholar 

  • Rose DM, Delbeke D, Beauchamp RD et al. (1999) 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Ann Surg 229:729–738

    Article  PubMed  CAS  Google Scholar 

  • Safi F, Roscher R, Bittner R et al. (1987) High sensitivity and specificity of CA 19-9 for pancreatic carcinoma in comparison to chronic pancreatitis. Serological and immunohistochemical findings. Pancreas 2:398–403

    Article  PubMed  CAS  Google Scholar 

  • Schima W, Függer R, Schober E et al. (2002) Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT. AJR Am J Roentgenol 179:717–724

    PubMed  Google Scholar 

  • Tempero M, Plunkett W, Ruiz Van Haperen V et al. (2003) Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 21:3402–3408

    Article  PubMed  CAS  Google Scholar 

  • Willett CG, Lewandrowski K, Warshaw AL et al. (1993) Resection margins in carcinoma of the head of the pancreas. Implications for radiation therapy. Ann Surg 217:144–148

    Article  PubMed  CAS  Google Scholar 

  • Xing L, Thorndyke B, Schreibmann E et al. (2006) Overview of image-guided radiation therapy. Med Dosim 31:91–112

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mehta, V.K. (2008). Pancreatic Cancer. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77385-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77384-9

  • Online ISBN: 978-3-540-77385-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics