Skip to main content
SpringerLink
Log in

Small Cell Lung Cancer

  • Chapter
Book cover Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. It is a systemic disease that requires multidisciplinary management. Both chemotherapy and radiation therapy are important treatment modalities in curative and palliative treatment of SCLC.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albain KS, Crowley JJ, Livingston RB (1991) Long-term survival and toxicity in small-cell lung cancer. Expended Southwest Oncology Group experience. Chest 99: 1425–1432

    Article  PubMed  CAS  Google Scholar 

  • Auperin A, Arriagada R, Pignon JP et al. (1999) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 341: 476–484

    Article  PubMed  CAS  Google Scholar 

  • Beith JM, Clarke SJ, Woods RL et al. (1996) Long-term follow-up of a randomised trial of combined chemoradiotherapy induction treatment, with and without maintenance chemotherapy in patients with small cell carcinoma of the lung. Eur J Cancer 32A: 438–443

    Article  PubMed  CAS  Google Scholar 

  • Bogart J, Herndon J, Lyss AP et al. (2002) 70 Gy thoracic radiotherapy is feasible concurrent with chemotherapy for limited stage small cell lung cancer: preliminary analysis of a CALGB phase II trial. Int J Radiat Oncol Biol Phys 54[2 suppl]:103

    Article  Google Scholar 

  • Bonner JA, Sloan JA, Shanahan TG et al. (1999) Phase III comparison of twice-daily split-course irradiation versus once-daily irradiation for patients with limited stage small cell lung carcinoma. J Clin Oncol 17: 2681–2691

    PubMed  CAS  Google Scholar 

  • Bradley JD, Dehdashti F, Mintun MA et al. (2004) Positron emission tomography in limited-stage small-cell lung cancer: a prospective study. J Clin Oncol 22:3248–3254

    Article  PubMed  Google Scholar 

  • Brink I, Schumacher T, Mix M et al. (2004) Impact of [18F] FDG-PET on the primary staging of small-cell lung cancer. Eur J Nucl Med Mol Imaging 31:1614–1620

    Article  PubMed  CAS  Google Scholar 

  • Byhardt RW, Hartz A, Libnoch JA et al. (1986) Prognostic influence of TNM staging and LDH levels in small cell carcinoma of the lung (SCLC). Int J Radiat Oncol Biol Physs 12:771–777

    CAS  Google Scholar 

  • Byhardt RW, Martin L, Pajak TF et al. (1993) The influence of field size and other treatment factors on pulmonary toxicity following hyperfractionated irradiation for inoperable non-small cell lung cancer — analysis of a Radiation Therapy Oncology Group protocol. Int J Radiat Oncol Biol Phys 27:537–544

    PubMed  CAS  Google Scholar 

  • Byrne MJ, van Hazel G, Trotter J et al. (1989) Maintenance chemotherapy in limited small-cell lung cancer: a randomized controlled clinical trial. Br J Cancer 60:413–418

    PubMed  CAS  Google Scholar 

  • Cerny T, Blair V, Anderson H, et al. (1987) Pretreatment prognostic factors and scoring system in 407 small cell lung cancer patients. Int J Cancer 39:146–149

    Article  PubMed  CAS  Google Scholar 

  • Choi NC, Herndon JE 2nd, Rosenman J et al. (1998) Phase I study to determine the maximum-tolerated dose of radiation in standard daily and hyperfractionated-accelerated twice-daily radiation schedules with concurrent chemotherapy for limited-stage small-cell lung cancer. J Clin Oncol 16:3528–3536

    PubMed  CAS  Google Scholar 

  • Chute JP, Venzon DJ, Hankins L et al. (1997) Outcome of patients with small-cell lung cancer during 20 years of clinical research at the US National Cancer Institute. Mayo Clin Proc 72:901–912

    Article  PubMed  CAS  Google Scholar 

  • Claude L, Pérol D, Ginestet C et al. (2004) A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis. Radiother Oncol 71:175–181

    Article  PubMed  Google Scholar 

  • Curran WJ Jr. (2001) Combined-modality therapy for limited-stage small cell lung cancer. Semin Oncol 28[2 Suppl 4]:14–22

    Article  PubMed  Google Scholar 

  • Dimopoulos MA, Fernandez JF, Samaan NA et al. (1984) Paraneoplastic Cushing’s syndrome as an adverse prognostic factor in patients who die early with small cell carcinoma of the lung. Am J Med 77:851–857

    Article  Google Scholar 

  • Emami B, Lyman J, Brown A et al. (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122

    PubMed  CAS  Google Scholar 

  • Giaccone G, Dalesio O, McVie GJ et al. (1993) Maintenance chemotherapy in small-cell lung cancer: long-term results of a randomized trial. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol 11:1230–1240

    PubMed  CAS  Google Scholar 

  • Govindan R, Page N, Morgensztern D et al. (2006) Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 24:4539–4544

    Article  PubMed  Google Scholar 

  • Gregor A, Cull A, Stephens RJ et al. (1997) Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: results of a multicentre randomized trial. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) and the European Organization for Research and Treatment of Cancer (EORTC). Eur J Cancer 33:1752–1758

    Article  PubMed  CAS  Google Scholar 

  • Jeremic B, Shibamoto Y, Acimovic L et al. (1997) Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study. J Clin Oncol 15:893–900

    PubMed  CAS  Google Scholar 

  • Johnson BE, Patronas N, Hayes W et al. (1990) Neurologic, computed cranial tomographic, and magnetic resonance imaging abnormalities in patients with small-cell lung cancer: further follow-up of 6-to 13-year survivors. J Clin Oncol 8:48–56

    PubMed  CAS  Google Scholar 

  • Kies MS, Mira JG, Crowley JJ et al. (1987) Multimodal therapy for limited small cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders; a Southwest Oncology Group study. J Clin Oncol 5:592–600

    PubMed  CAS  Google Scholar 

  • Komaki R, Meyers CA, Shin DM et al. (1995) Evaluation of cognitive function in patients with limited small-cell lung cancer prior to and shortly following prophylactic cranial irradiation. Int J Radiat Oncol Biol Phys 33:179–182

    PubMed  CAS  Google Scholar 

  • Kotalik J, Yu E, Markman BR et al. (2001) Practice guideline on prophylactic cranial irradiation in small-cell lung cancer. Int J Radiat Oncol Biol Phys 50:309–316

    Article  PubMed  CAS  Google Scholar 

  • Liengswangwong V, Bonner JA, Shaw EG et al. (1994) Limited stage small-cell lung cancer: patterns of intrathoracic recurrence and the implications for thoracic radiotherapy. J Clin Oncol 12:496–502

    PubMed  CAS  Google Scholar 

  • Line DH, Deeley TJ (1971) The necropsy findings in carcinoma of the bronchus. Br J Dis Chest 65:238–242

    Article  PubMed  CAS  Google Scholar 

  • List AF, Hainsworth JD, Davis BW et al. (1986) The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in small cell lung cancer. J Clin Oncol 4:1191–1198

    PubMed  CAS  Google Scholar 

  • Loehrer PJ Sr, Einhorn LH, Greco FA (1988) Cisplatin plus etoposide in small cell lung cancer. Semin Oncol 15[3 Suppl 3]:2–8

    PubMed  Google Scholar 

  • Movsas B, Raffin TA, Epstein AH et al. (1997) Pulmonary radiation injury. Chest 111:1061–1076

    Article  PubMed  CAS  Google Scholar 

  • Murray N, Coy P, Pater JL et al. (1993) Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 11:336–344

    PubMed  CAS  Google Scholar 

  • National Comprehensive Cancer Network (2008) Clinical practice guidelines in oncology: small-cell lung cancer. Available at http://www.nccn.org/ Accessed on March 30, 2008

    Google Scholar 

  • Paesmans M, Sculier JP, Lecomte J et al. (2000) Prognostic factors for patients with small cell lung carcinoma: analysis of a series of 763 patients included in 4 consecutive prospective trials with a minimum follow-up of 5 years. Cancer 89:523–533

    Article  PubMed  CAS  Google Scholar 

  • Pignon JP, Arriagada R, Ihde DC et al. (1992) A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 327:1618–1624

    PubMed  CAS  Google Scholar 

  • Radiation Therapy Oncology Group (2007) Active lung cancer protocols. Available at http://www.rtog.org/members/active.html#lung. Accessed on October 23, 2007

    Google Scholar 

  • Sculier JP, Paesmans M, Bureau G et al. (1996) Randomized trial comparing induction chemotherapy versus induction chemotherapy followed by maintenance chemotherapy in small-cell lung cancer. European Lung Cancer Working Party. J Clin Oncol 14:2337–2344

    PubMed  CAS  Google Scholar 

  • Shepherd FA, Ginsberg RJ, Patterson GA et al. (1989) A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer. A University of Toronto Lung Oncology Group study. J Thorac Cardiovasc Surg 97:177–186

    PubMed  CAS  Google Scholar 

  • Skarlos DV, Samantas E, Kosmidis P et al. (1994) Randomized comparison of etoposide-cisplatin vs. etoposide-carboplatin and irradiation in small-cell lung cancer. A Hellenic Co-operative Oncology Group study. Ann Oncol 5:601–607

    PubMed  CAS  Google Scholar 

  • Stahel RA, Ginsberg R, Havermann K et al (1989) Staging and prognostic factors in small cell lung cancer: a consensus. Lung Cancer 5:119–126

    Article  Google Scholar 

  • Sundstrøm S, Bremnes RM, Kaasa S et al. (2002) Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years’ follow-up. J Clin Oncol 20:4665–4672

    Article  PubMed  Google Scholar 

  • Slotman B, Faivre-Finn C, Kramer G et al. (2007) Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med 357:664–672

    Article  PubMed  CAS  Google Scholar 

  • Suwinski R, Lee SP Withers HR (1998) Dose-response relationship for prophylactic cranial irradiation in small-cell lung cancer. Int J Radiat Oncol Biol Phys 40:797–806

    Article  PubMed  CAS  Google Scholar 

  • Turrisi AT 3rd, Kim K, Blum R et al. (1999) Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 340:265–271

    Article  PubMed  CAS  Google Scholar 

  • Warde P, Payne D (1992) Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis. J Clin Oncol 10:890–895

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, National University Cancer Institute of Singapore, National University Health System, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Jiade J. Lu MD, MBA

Authors
  1. Jiade J. Lu MD, MBA
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology National University Cancer Institute of Singapore National University Health System, National University of Singapore, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  2. Department of Radiation Oncology, Cancer Hospital of Fudan University, 270 Dong An Road, Shanghai, 200232, P.R. China

    Jiade J. Lu MD, MBA (Associate Professor and Consultant and Distinguished Clinical Professor) (Associate Professor and Consultant and Distinguished Clinical Professor)

  3. College of Medicine, Drexel University, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Hylda Cohn/American Cancer Society Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lu, J.J. (2008). Small Cell Lung Cancer. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-77385-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77384-9

  • Online ISBN: 978-3-540-77385-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation