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Extracorporeal Life-Support for Acute Drug-induced Cardiac Toxicity

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2008))

Abstract

Cardiovascular toxicity is a potential complication following accidental or intentional overdose with various classes of drugs. The term ‘cardio-toxic drug’ is not limited to cardiovascular drugs but also includes various other toxicants, such as antidepressants, meprobamate, H1-antihistaminic agents, nivaquine, cocaine, organophosphates, cyanide, and plants (Table 1). Despite improvement in critical care, drug-induced cardiovascular failure still remains a leading cause of death. The mortality rate remains high in poisonings with compounds that include membrane stabilizing agents in addition to their main pharmacological activity [1]. Of 847,483 exposures in adults reported to the American Association of Poison Control Centers in 2005, cardiovascular drugs were involved in 5.8 % of cases; however, they accounted for approximately 19 % of the total 1,261 poisoning fatalities, representing

Cardio-toxic drugs causing severe acute heart failure that may require extracorporeal life support.

the fifth toxicant category responsible for death, following analgesics, sedative drugs, antidepressants, and stimulants [2]. In this register, calcium channel blockers and beta-blockers accounted for 40 % of cardiovascular drug exposures, while calcium channel blockers represented the first cause of cardiovascular agent-related death.

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Authors and Affiliations

  1. Medical Intensive Care and Toxicology, Hôpital Lariboisière, 2, Rue Ambroise Paré, 75010, Paris, France

    B. Mégarbane, N. Deye & F. J. Baud

Authors
  1. B. Mégarbane
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  2. N. Deye
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  3. F. J. Baud
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© 2008 Springer-Verlag Berlin Heidelberg

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Mégarbane, B., Deye, N., Baud, F.J. (2008). Extracorporeal Life-Support for Acute Drug-induced Cardiac Toxicity. In: Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77290-3_17

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  • DOI: https://doi.org/10.1007/978-3-540-77290-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77289-7

  • Online ISBN: 978-3-540-77290-3

  • eBook Packages: MedicineMedicine (R0)

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