Abstract
We do not know when and where drink able grape juice was originally pressed from wild vines, nor when and where wine was produced and enjoyed for the first time following fermentation and purification. • The oldest find is probably a grape squeezer containing grape seeds found in the region south of Damascus, dating back to the time around 6000 bc. • Wine consumption and drunkenness are described in the Epic of Gilgamesh, which goes back to 4000–3000 bc. God told Noah, who is called Utnapishtim in the epic, to grow grapevines following the Flood (around 4000 bc). This he did: “And he drank of the wine, and was drunken” (Genesis, 9.21). • About 2700 bc, Chinese writings mention the benefits as well as the dangers of consuming wine. • Many descriptions pertaining to the consumption of wine (and also beer) as well as to drunkenness can be found in the rock tombs at El Kab in Upper Egypt (around 2500 bc), in the Eber’s Papyrus (around 1550 bc) and in various other discoveries. A Babylonian clay tablet from the year 2230 BC shows a prescription written by a Sumerian physician regarding the use ofwine formedical purposes.
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References
Achord, J.L.: Malnutrition and the role of nutritional support in alcoholic liver disease. Amer. J. Gastroenterol. 1987; 82: 1–7
Agarwal, D.P., Goedde, H.W.: Medicobiological and genetic studies on alcoholism. Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality. Clin. Invest. 1992; 70: 465–477
Akriviadis, E., Botla, R., Briggs, W., Han, S., Reynolds, T., Shakil, O.: Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 2000; 119: 1637–1648
Arico, S., Galatola, G., Tabone, M., Corrao, G.: Amount and duration of alcoholic intake in patients with chronic liver disease: an Italian multicentre study. Ital., J. Gastroenterol. 1994; 26: 59–65
Arteel, G., Marsano, I., Mendez, C., Bentley, F., McClain, C.J.: Advances in alcoholic liver disease. Best Pract. Clin. Gastroenterol. 2003; 17: 625–647
Baldi, E., Burra, P., Plebani, M., Salvagnini, M.: Serum malondialdehyde and mitochondrial aspartate aminotransferase activity as markers of chronic alcohol intake and alcoholic liver disease. Ital. J. Gastroenterol. 1993; 25: 429–432
Baptista, A., Bianchi, L., de Groote, J., Desmet, V.J., Gedigk, P., Korb, G., MacSween, R.N.M., Popper, H., Poulsen, H., Scheuer, P.J., Schmid, M., Thaler, H., Wepler, W.: Alcoholic liver disease: morphological manifestations. Review by an International Group. Lancet 1981/I: 707–711
Bassendine, M.F., Day, C.P.: The inheritance of alcoholic liver disease. Baill. Clin. Gastroenterol. 1998; 12: 317–335
Bell, H., Skinningsrud, A., Raknerud, N., Try, K.: Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. J. Intern. Med. 1994; 236: 315–322
Bird, G.L.A., Sheron, N., Goka, A.K.J., Alexander, G.J., Williams, R.: Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann. Intern. Med. 1990; 112: 917–920
Black, M., Tavill, A.S.: Corticosteroids in severe alcoholic hepatitis. Ann. Intern. Med. 1989; 110: 677–680
Bode, J.C., Kruse, G., Mexas, P., Martini, G.A.: Alkoholfettleber, Alkoholhepatitis und Alkoholzirrhose. Trinkverhalten und Häufigkeit klinischer, klinisch-chemischer und histologischer Befunde bei 282 Patienten. Dtsch. Med. Wschr. 1984; 109: 1516–1521
Bosron, W.F., Ehrig, T., Li, T.-K.: Genetic factors in alcohol metabolism and alcoholism. Semin. Liver Dis. 1993; 13: 126–135
Bradford, B.U., Enomoto, N., Ikejima, K., Rose, M.L., Bojes, H.K., Forman, D.T., Thurman, R.G.: Peroxisomes are involved in the swift increase in alcohol metabolism J. Pharm. Exper. Ther. 1999; 288: 254–259
Bradlow, A., Mowat, A.G.: Dupuytren’s contracture and alcohol. Ann. Rheum. 1986; 45: 304–309
Brillanti, S., Masci, C., Siringo, S., di Febo, G., Miglioli, M., Barbara, L.: Serological and histological aspects of hepatitis C virus infection in alcoholic patients. J. Hepatol. 1991; 13: 347–350
Caballeria, J.: First-pass metabolism of ethanol: its role as determinant of blood alcohol levels after drinking. Hepato-Gastroenterol 1992; 39: 62–66
Caldwell, St.H., Jeffers, L.J., Ditomaso, A., Millar, A., Clark, R.M., Rabassa, A., Reddy, R., de Medina, M., Schiff, E.R.: Antibody to hepatitis C is common among patients with alcoholic liver disease with and without risk factors. Amer. J. Gastroenterol. 1991; 86:1219–1223
Carithers, R.L.jr.; Herlong, H.F., Diehl, A.M., Shaw, E.W., Combes, B., Fallon, H.J., Maddrey, W.C.: Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. Ann. Intern. Med. 1989; 110: 685–690
Chan, A.W.K., Welte, F.W., Whitney, R.B.: Identification of alcoholism in young adults by blood chemistries. Alcohol 1987; 4: 175–179
Chedid, A., Mendenhall, C.L., Tosch, T., Chen, T., Rabin, L., Garcia-Pont, P., Goldberg, S.J., Kiernan, T., Seeff, L.B., Sorrell, M., Tamburro, C., Weesner, R.E., Zetterman, R.: Significance of megamitochondria in alcoholic liver disease. Gastroenterology 1986; 90: 1858–1864
Chedid, A., Mendenhall, C.L., Gartside, P., French, S.W., Chen, T., Rabin, L.: Prognostic factors in alcoholic liver disease. Amer. J. Gastroenterol. 1991; 86: 210–216
Christensen, E.: Alcoholic hepatitis — glucocorticosteroids or not? J. Hepatol. 2002; 36: 547–548
Clark, S.A., Angus, H.B., Cook, H.B., George, P.M., Oxner, R.B.G., Fraser, R.: Defenestration of hepatic sinusoids as a cause of hyperlipo-proteinaemia in alcoholics. Lancet 1998/II: 1225–1227
Colli, A., Massironi, S., Faccioli, P., Conte, D.: “Pseudotumoral” hepatic areas in acute alhoholic hepatitis. A computed tomography and histological study. Amer. J. hastroenterol. 2005; 100: 831–836
Colombat, M., Charlotte, F., Ratzin, V., Poynard, T.: Portal lymphocytic infiltrate in alcoholic liver disease. Hum. Path. 2002; 33: 1170–1174
Cortez-Pinto, H., Alexandrino, P., Camilo, M.E., Gouveia-Oliveira, A., Santos, P.M., Alves, M.M., Moura, M.C.: Lack of effect of colchicine in alcoholic cirrhosis: Final results of a double blind randomized trial. Eur. J. Gastroenterol. Hepatol. 2002; 14: 377–381
Crabb, D.W.: Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. J. Clin. Invest. 1990;85: 311–315
Day, C.P., Yeaman, S.J.: The biochemistry of alcohol-induced fatty liver. Biochem. Biophys. Acta 1994; 1215: 33–48
De Feo, T.M., Fargion, S., Duca, L., Mattioli, M., Cappellini, M.D., Sampietro, M., Cesana, B.M., Fiorelli, G.: Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron. Hepatology 1999; 29: 658–663
Denk, H., Stumptner, C., Zatloukal, K.: Mallory bodies revisited. J. Hepatol. 2000; 32: 689–702
Dick, M.M., Foroud, T.: Candidate genes for alcohol dependence. A review of genetic evidence from human studies. Alcoh. Clin. Exper. Res. 2003; 27: 868–879
Diehl, A.M.: Alcoholic liver disease. Med. Clin. North. Amer. 1989; 73: 815–830
Dilger, K., Metzler, J., Bode, J.C., Klotz, U.: CYP 2 E1 activity in patients with alcoholic liver disease. J. Hepatol. 1997; 27: 1009–1014
Fabrega, E., Orive, A., Garcia-Suarez, C., Garcia-Unzuela, M., Amado, J.A., Pons-Romero, F.: Osteoprotegerin and RANKL in alcoholic liver cirrhosis. Liver Internat. 2005; 25: 305–310
Faller, J., Fox, I.H.: Ethanol-induced hyperuricemia. New Engl. J. Med. 1982; 307: 1598–1602
Fantozzi, R., Caramelli, L., Ledda, F., Moroni F., Masini, E., Blandina, P., Botti, P., Peruzzi, S., Zorn, A.M., Mannaioni, P.F.: Biological markers and therapeutic outcome in alcoholic disease: a twelve-year survey. Klin. Wschr. 1987; 65: 27–33
Fong, T.-L., Kanel, G.C., Conrad, A., Valinluck, B., Charboneau, F., Adkins, R.H.: Clinical significance of concomitant hepatitis C infection in patients with alcoholic liver disease. Hepatology 1994; 19: 554–557
French, S.W.: Mechanisms of alcoholic liver injury. Canad. J. Gastroenterol. 2000; 14: 327–332
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., Lieber, C.S.: High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. New Engl. J. Med. 1990; 322: 95–99
Gertsch, P.: Transplantation hépatique chez le cirrhotique alcoolique: arguments pour. Schweiz. Med. Wschr. 1992; 122: 631–633
Gjerde, H., Johnsen, J., Bjorneboe, A., Bjorneboe, G.-E.A.A., Morland, J.: A comparison of serum carbohydrate-deficient transferrin with other biological markers of excessive drinking. Scand. J. Lab. Invest. 1988; 48: 1–6
Godart, B., Mennetrey, L., Schellenberg, F., Pages, J.C., Bacq, Y.: Carbohydrate — deficient transferrin and gamma-glutamyl transpeptidase in the evaluation of alcohol consumption. A five-year retrospective study of 633 outpatients in a single center. Gastroenterol. Clin. Biol. 2005; 29: 113–116
Goedde, H.W., Agarwal, D.P., Fritze, G.: Frequency of ALDH2 and ALDH5 genotypes in different populations and implications for alcohol sensitivity and alcohol drinking habits Hum. Genet. 1992; 88: 344–346
Goldin, R.: The pathogenesis of alcoholic liver disease. Int. J. Exp. Path. 1994; 75: 71–78
Goodman, Z.D., Ishak, K.G.: Occlusive venous lesions in alcoholic liver disease. A study of 200 cases. Gastroenterology 1982; 83: 786–796
Gubbins, G.P., Moritz, T.E., Marsano, L.S., Talwalkar, R., McClain, C.J., Mendenhall, C.L., VA-Group Helicobacter pylori is a risk factor for hepatitic encephalopathy in acute alcoholic hepatitis: the ammonia hypothesis revisited. Amer. J. Gastroenterol. 1993; 88: 1906–1910
Haber, P.S., Warner, R., Seth, D., Gorrell, M.D., McCaughan, G.W.: Pathogenesis and management of alcoholic hepatitis (review). J. Gastroenterol. Hepatol. 2003; 18: 1332–1344
Han, S.H.B., Rice, S., Cohen, S.M., Reynolds, T.B., Fong, T.L.: Duplex Doppler ultrasound of the hepatic artery in patients with acute alcoholic hepatitis. J. Clin. Gastroenterol. 2002; 34: 573–577
Hall, P.M. de la: The pathological spectrum of alcoholic liver disease. Pathology 1985; 17: 209–218
Hayes, P.C., Bell, D., Plevris, J.N., Dawes, J., Bouchier, I.A.D.: Free radical production and neutrophil activation in the pathogenesis of alcoholic liver disease. Eur. J. Gastroenterol. 1989; 1: 101–105
Hessel, F.P., Mitzner, S.R., Rief, J., Guellstorff, B., Steiner, S., Wasem, J.: Economic evaluation and 1-year survival analysis of MARS in patients with alcoholic liver disease. Liver Internat. 2003; 23: 66–72
Hill, D.B., McClain, C.J.: Anti-TNF therapy in alcoholic hepatitis (editorial). Amer. J. Gastroenterol. 2004; 99: 261–263
Hintze, G., Cüppers, H.J., Mokry, H., Hein, D., Köbberling, J.: Die alkoholische Ketoacidose. Eine wichtige Differentialdiagnose zur diabetischen Ketoacidose. Dtsch. Med. Wschr. 1988; 113: 725–727
Horn, T., Christoffersen, P., Henriksen, J.H.: Alcoholic liver injury: Defenestration in noncirrhotic livers — a scanning electron microscopic study. Hepatology 1987; 7: 77–82
Hultberg, B., Isaksson, P., Berglund, M., Moberg, A.-L.: Serum β-hexosaminidase isoenzymze: a sensitive marker for alcohol abuse. Alcohol. Clin. Exp. Res. 1991; 15: 549–552
Imperiale, T.F., McCullough, A.J.: Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. Ann. Intern. Med. 1990; 113: 299–307
Ishii, H., Ebihara, Y., Okuno, F., Munakata, Y., Takagi, T., Arai, M., Shigeta, S., Tsuchiya, M.: γ-Glutamyl transpeptidase activity in liver of alcoholics and its histochemical localization. Alcohol. Clin. Exper. Res. 1986; 10: 81–85
Israel, Y., Orrego, H., Niemelae, O.: Immune responses to alcohol metabolites: pathogenic and diagnostic implications. Semin. Liver Dis. 1988; 8: 81–90
Isselbacher, K.J.: Metabolic and hepatic effects of alcohol. New Engl. J. Med. 1977; 296: 612–616
Jacobs, R.M., Sorrell, M.F.: The role of nutrition in the pathogenesis of alcoholic liver disease. Semin. Liver Dis. 1981; 1: 244–253
Jalan, R., Sen, S., Steiner, C., Kapoor, D., Alisa, A., Williams, R.: Extracorporeal liver support with molecular adsorbent recirculating system in patients with severe acute alcoholic hepatitis. J. Hepatol. 2003; 38: 24–31
Junge, J., Horn, T., Vyberg, M., Christoffersen, P., Svendsen, L.B.: The pattern of fibrosis in the acinar zone 3 areas in early alcoholic liver disease. J. Hepatol. 1991; 12: 83–86
Kagata, Y., Okudaira, M., Uchikoshi, T., Nakano, M.: Histological study on alcoholic liver disease. Acta Hepatol. Japon. 1993; 34: 710–717
Kearns, P.J., Young, H., Garcia, G., Blaschke, T., O’Hanlon, G., Rinki, M., Sucher, K., Gregory, P.: Accelerated improvement of alcoholic liver disease with enteral nutrition. Gastroenterology 1992; 102: 200–205
Keshavarzian, A., Holmes, E.W., Patel, M., Iber, F., Fields, J.Z., Pethkar, S.: Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage. Amer. J. Gastroenterol. 1999; 94: 200–207
Kuntz, E.: Alkohol als soziale und ökonomische Belastung. Münch. Med. Wschr. 1984; 126: 549–552
Laskin, C.A., Vidins, E., Blendis, L.M., Soloninka, C.A.: Autoantibodies in alcoholic liver disease. Amer. J. Med. 1990; 89: 129–133
Lelbach, W.K.: Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann. NY Acad. Sci. 1975; 252: 85–105
Lester, R., Eagon, P.K., van Thiel, D.H.: Feminization of the alcoholic: the estrogen/testosterone ratio (E/T). Gastroenterology 1979; 76: 415–417
Li, J., Kim, C., Leo, A.M., Mak, K.M., Rojkind, M., Lieber, C.S.: Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes. Hepatology 1992; 15: 373–381
Lieber, C.S.: Biochemical factors in alcoholic liver disease. Semin. Liver Dis. 1993; 3: 136–153
Lieber, C.S., Robins, S.J., Li, J.J., DeCarli, L.M., Mak, K.M., Fasulo, J.M., Leo, M.A.: Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 1994; 106: 152–159
Lieber, C.S.: Hepatic and metabolic effects of ethanol: pathogenesis and prevention. Ann. Med. 1994; 26: 325–330 • Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 1997; 257: 59–84 • Role of oxidative stress and antioxidant therapy in alcoholic and non-alcoholic liver diseases. Adv. Pharmacol. 1997; 38: 601–628
Lieber, C.S.: Alcoholic liver disease: new insights in pathogenesis lead to new treatments. J. Hepatol. 2000; 32 (Suppl. 1): 113–128
Lindros, K.O.: Alcoholic liver disease: pathobiological aspects. J. Hepatol. 1995; 23 (Suppl. 1): 7–15
Lotterer, E., Gressner, A.M., Kropf, J., Grobe, E., von Knebel, D., Bircher, J.: Higher levels of serum aminoterminal type III procollagen peptide, and laminin in alcoholic than in nonalcoholic cirrhosis of equal severity. J. Hepatol. 1992; 14: 71–77
Lucey, M.R., Beresford, T.P.: Alcoholic liver disease: to transplant or not to transplant? Alcohol Alcoholism 1992; 27: 103–108
Lumeng, L. Crabb, D.W.: Genetic aspects and risk factors in alcoholism and alcoholic liver disease. Gastroenterology 1994; 107: 572–578
Lumeng, L., Crabb, D.W.: Alcoholic liver disease. Curr. Opin. Gastroenterol. 2001; 17: 211–220
Maddrey, W.C.: Alcoholic hepatitis: clinicopathologic features and therapy. Semin. Liver. Dis. 1988; 8: 91–102
Madhotra, R., Gilmore, I.T.: Recent developments in the treatment of alcoholic hepatitis. Quart. J. Med. 2003; 96: 391–400
Maher, J.J.: Hepatic fibrosis caused by alcohol. Semin. Liver Dis. 1990; 10: 66–74
Mallach, H.J., Pedal, I., Völz, T.: Über tödliche Alkoholvergiftungen. Med. Welt 1980; 31: 1657–1661
Mathurin, P., Abdelnour, M., Ramond, M.J., Carbonell, N., Fartoux, L., Serfaty, L., Valla, D., Poupon, R., Chaput, J.C., Naveau, S.: Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology 2003; 36: 1363–1369
Matloff, D.S., Selinger, M.J., Kaplan, M.M.: Hepatic transaminase activity in alcoholic liver disease. Gastroenterology 1989; 78: 1389–1392
Mato, J.M., Camara, J., Fernandez-de-Paz, J., Caballeria, L., Coll, S., Caballero, A., Garcia-Buey, L., Beltran, J., Benita, V., Caballeria, J., Sola, R., Moreno-Otero, R., Barrao, F., Martin-Duce, A., Correa, J.A., Pares, A., Barrao, E., Garcia-Magaz, I., Puerta, J.L., Moreno, J., Boissard, G., Ortiz, P., Rodes, J.: S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J. Hepatol. 1999; 30: 1081–1089
Mayfield, D., McLeod, G., Hall, P.: The CAGE questionnaire: validation of a new alcoholism screening instrument. Amer. J. Psychiat. 1974; 131: 1121–1123
McCullogh, A.J., O’Connor, J.F.B.: Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Amer. J. Gastroenterol. 1998; 93: 2022–2036
Mezey, E., Caballeria, J., Mitchell, M.C., Pares, A., Herlong, H.F., Rodes, J.: Effect of parenteral amino acid supplementation on shortterm and long-term outcomes in severe alcoholic hepatitis: a randomized controlled trial. Hepatology 1991; 14: 1090–1096
Mezey, E., Potter, J.J., Rennie-Tankersley, L., Caballeria, J., Pares, A.: A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J. Hepatol. 2004; 40: 40–46
Michalak, S., Rousselet, M.C., Bedossa, P., Pilette, C., Chappard, D., Oberti, F., Gallois, Y., Cales, P.: Respective roles of porto-septal fibrosis and centrilobular fibrosis in alcoholic liver disease. J. Path. 2003; 201: 55–62
Mills, P.R., Spooner, R.J., Russell, R.I., Boyle, P., MacSween, R.N.M.: Serum glutamate dehydrogenase as a marker of hepatocyte necrosis in alcoholic liver disease. Brit. Med. J. 1981; 283: 754–755
Morris, J.M., Forrest, E.H.: Bilirubin response to corticosteroids in severe alcoholic hepatitis. Eur. Gastroenterol. Hepatol. 2005; 17: 759–762
Müller, M.J.: Alcohol and body weight. Z. Gastroenterol. 1999; 37: 33–43
Nalpas, B., Hispard, E., Thépot, V., Pot, St., Dally, S., Berthelot, P.: A comparative study between carbohydrate-deficient transferrin and gamma-glutamyltransferase for the diagnosis of excessive drinking in a liver unit. J. Hepatol. 1997; 27: 1003–1008
Naveau, S., Balian, A., Capron, F., Raynard, B.R., Fallik, D., Agostini, H., Grangeot-Keros, L., Portier, A., Galanaud, P., Chaput, J.C., Emilie, D.: Balance between pro-and antiinflammatory cytokines in patients with acute alcoholic hepatitis. Gastroenterol. Clin. Biol. 2005; 29: 269–274
Naveau, S., Chollet-Martin, S., Dharancy, S., Mathurin, P., Jonet, P., Piquet, M.A., Davion, T., Oberti, F., Broet, P., Emilie, D.: A doubleblind randomized controlled trial of infliximab associated with prednisolon in acute alcoholic hepatitis. Hepatology 2004; 39: 1390–1397
Niemelä, O., Risteli, J., Blake, J.E., Risteli, L., Compton, K.V., Orrego, H.: Markers of fibrogenesis and basement membrane formation in alcoholic liver disease. Relation to severity, presence of hepatitis, and alcohol intake. Gastroenterology 1990; 98: 1612–1619
Niemelä, O., Parkilla, S., Britton, R.S., Brunt, E., Bacon, B.: Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury. J. Lab. Clin. Med. 1999; 133: 451–460
Nissenbaum, M., Chedid, A., Mendenhall, C., Gartside, P.: Prognostic significance of cholestatic alcoholic hepatitis. Dig. Dis. Sci. 1990; 35: 891–896
Norton, R., Batey, R., Dwyer, T., MacMahon, St.: Alcohol consumption and the risk of alcohol-related cirrhosis in women. Brit. Med. J. 1987; 295: 80–82
Ohtomo, K., Baron, R.L., Dodd III, G.D., Federle M.P., Miller, W.J., Campbell, W.L., Cofner, S.R., Weber, K.M.: Confluent fibrosis in advanced cirrhosis: appearance at CT. Radiology 1993; 188: 31–35
Orrego, H., Blake, J.E., Blendis, L.M., Medline, A.: Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis. Gastroenterology 1987; 92: 208–214
Osorio, R.W., Ascher, N.L., Avery, M., Bacchetti, P., Roberts, J.P., Take, J.R.: Predicting recidivism after orthotopic liver transplantation for alcoholic liver disease. Hepatology 1994; 20: 105–110
Pares, A., Caballeria, J., Bruguera, M., Torres, M., Rode, J.: Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage. J. Hepatol. 1986; 2: 33–42
Parés, A., Barrera, J.M., Caballeria, J., Ercilla, G., Bruguera, M., Caballeria, L., Castillo, R., Rodes, J.: Hepatitis C virus antibodies in chronic alcoholic patients: association with severity of liver injury. Hepatology 1990; 12: 1295–1299
Parlesak, A., Schäfer, C., Schütz, T., Bode, J.C., Bode, C.: Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J. Hepatol. 2000; 32: 742–747
Pequignot, G., Chabet, C., Eydoux, H., Courcoul, M.A.: Augmentation du risque de cirrhose en fonction de la ration ďalcohol. Rev. Alcohol. 1974; 20: 192–201
Pessione, F., Ramond, M.C., Peters, L., Pham, B.N., Batel, P., Rueff, B., Valla, D.C.: Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis, smoking and abstinence. Liver Internat. 2003; 23: 45–53
Phillips, M., Curtis, H., Portmann, B., Donaldson, N., Bomford, A., O’Grady, J.: Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis. A randomised clinical trial. J. Hepatol. 2006; 44: 784–790
Plevris, J.N., Hauer, J.L., Hayes, P.C., Bouchier, I.A.D.: The hands in alcoholic liver disease. Amer. J. Gastroenterol. 1991; 86: 467–471
Poynard, T., Aubert, A., Bedossa, P., Abella, A., Naveau, S., Paraf, F., Chaput, J.C.: A simple biological index for detection of alcoholic liver disease in drinkers. Gastroenterology 1991; 100: 1397–1402
Poynard, T., Barthelemy, P., Fratte, S., Boudjema, K., Doffoel, M., Vanlemmens, C., Miguet, J.P., Mantion, G., Messner, M., Launois, B., Naveau, S., Chaput, J.C.: Evaluation of efficacy of liver transplantation in alcoholic cirrhosis by a case-control study and simulated controls. Lancet 1994; 344: 502–507
Ramond, M.-J., Poynard, T., Rueff, B., Mathurin, P., Théodore, C., Chaput, J.-C., Benhamou, J.-P.: A randomized trial of prednisolone in patients with severe alcoholic hepatitis. New Engl. J. Med. 1992; 326: 507–512
Rohner, A.: La transplantation hépatique dans la cirrhose alcoolique est-elle légitime? Schweiz. Med. Wschr. 1992; 122: 628–630
Roine, R.P., Turpeinen, U., Ylikahri, R., Salaspuro, M.: Urinary dolichol — a new marker of alcoholism. Alcohol. Clin. Exp. Res. 1987; 11: 525–527
Roine, R.P., Erikson, C.J.P., Ylikahri, R., Penttilä, A., Salaspuro, M.: Methanol as a marker of alcohol abuse. Alcohol. Clin. Exp. Res. 1989; 13: 172–175
Rosman, A.S., Paronetto, F., Galvin, K., Williams, R.J., Lieber, C.S.: Hepatitis C virus antibody in alcoholic patients. Arch. Intern. Med. 1993; 153: 965–969
Sass, D.A., Shaikh, O.S.: Alcoholic hepatitis. Clin. Liver Dis. 2006; 10: 219–237
Savolainen, V., Perola, M., Lalu, K., Penttilä, A., Virtanen, I., Karhunen, P.J.: Early perivenular fibrogenesis — precirrhotic lesions among moderate alcohol consumers and chronic alcoholics. J. Hepatol. 1995; 23: 524–531
Schenker, S., Halff, G.A.: Nutritional therapy in alcoholic liver disease. Semin. Liver Dis. 1993; 13: 196–209
Schlemmer, H.-P.W., Sawatzki, T., Sammet, S., Dornacher, I., Bachert, P., van Kaick, G., Waldherr, R., Seitz, H.K.: Hepatic phospholipids in alcoholic liver disease assessed by proton-decoupled (31) P magnetic resonance spectroscopy. J. Hepatol. 2005; 42: 752–759
Seitz, H.K., Egerer, G., Simanowski, U.A., Waldherr, R., Ecky, R., Agarwal, D.P., Goedde, H.W., v. Wartburg, J.-P.: Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. Gut 1993; 34: 1433–1437
Serra, M.A., Escudero, A., Rodriguez, F., del Olmo, J.A., Rodrigo, J.M.: Effect of hepatitis C virus infection and abstinence from alcohol on survival in patients with alcoholic cirrhosis. J. Clin. Gastroenterol. 2003; 36: 170–174
Sharpe, P.C., McBride, R., Archbold, G.P.R.: Biochemical markers of alcohol abuse. Quart. J. Med. 1996; 89: 137–144
Sillanaukee, P.: The diagnostic value of a discriminant score in the detection of alcohol abuse. Arch. Path. Lab. Med. 1992; 116: 924–929
Simanowski, U.A., Egerer, G., Oneta, C., Keil, T., Pares, X., Conradt, C., Arce, L., Waldherr, R., Stickel, F., Russell, R.M., Aderjan, R., Klee, F., Seitz, H.K.: Helicobacter pylori infection decreases gastric alcohol dehydrogenase activity and first-pass metabolism of ethanol in man. Digestion 1998; 59: 314–320
Simon, D., Galambos, J.T.: A randomized controlled study of peripheral parenteral nutrition in moderate and severe alcoholic hepatitis. J. Hepatol. 1988; 7: 200–207
Soyka, M., Gilg, T., von Meyer, L., Ora, I.: Methanolstoffwechsel bei chronischem Alkoholismus. Wien. Klin. Wschr. 1991; 103: 684–689
Stibler, H.: Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin. Chem. 1991; 37: 2029–2037
Stickel, F., Schuppan, D., Hahn, E.G., Seitz, H.K.: Cocarcinogenic effects of alcohol in hepatocarcinogenesis (review). Gut 2002; 51: 132–139
Stickel, F., Hoehn, B., Schuppan, D., Seitz, H.K.: Review article: Nutritional therapy in alcoholic liver disease. Alim. Pharm. Ther. 2003; 18: 357–373
Sumino, Y., Kravetz, D., Kanel, G.C., McHutchinson, J.G., Reynolds, T.B.: Ultrasonographic diagnosis of acute alcoholic hepatitis “pseudoparallel channel sign” of intrahepatic artery dilation. Gastroenterology 1993; 105: 1477–1488
Suri, S., Mitros, F.A., Ahluwalia, J.P.: Alcoholic foamy degeneration and a markedly elevated GGT. A case report and literature review. Dig. Dis. Sci. 2003; 48: 1142–1146
Takase, S., Tsutsumi, M., Kawahara, H., Takada, N., Takada, A.: The alcohol-altered liver membrane antibody and hepatitis C virus infection in the progression of alcoholic liver disease. Hepatology 1993; 17: 9–19
Tamburro, C.H., Lee, H.M.: Primary hepatic cancer in alcoholics. Clin. Gastroenterol. 1981; 10: 457–477
Tanner, A.R., Bantock, I., Hinks, L., Lloyd, B., Turner, N.R., Wright, R.: Depressed selenium and vitamin E levels in an alcoholic population: possible relationship to hepatic injury through increased lipid peroxidation. Dig. Dis. Sci. 1986; 31: 1307–1312
Thabut, D., Naveau, S., Charlotte, F., Massard, J., Ratzin, V., Imbert-Bismut, F., Cazals-Hatem, D., Abella, A., Messous, D., Beuzen, F., Munteanu, M., Taieb, J., Moreau, R., Lebrec, D., Poynard, T.: The diagnostic value of biomarkers (Ash Test) for the prediction of alcoholic steato-hepatitis in patients wit chronic alcoholic liver disease. J. Hepatol. 2006; 44: 1175–1185
Tome, S., Lucey, M.R.: Review article: Current management of alcoholic liver disease. Aliment. Pharm. Ther. 2004; 19: 707–714
Van de Casteele, M., Zaman, Z., Zeegers, M., Servaes, R., Fevery, J., Nevens, F.: Blood antioxidant levels in patients with alcoholic liver disease correlate with the degree of liver impairment and are not specific to alcoholic liver injury itself. Alim. Pharm. Ther. 2002; 16: 985–992
Van de Wiel, A., van Hattum, J., Schuurman, H.-J., Kater, L.: Immunoglobulin A in the diagnosis of alcoholic liver disease. Gastroenterology 1988; 94: 457–462
Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Santoni, S., Reboldi, G., Brunetti, P., Bolli, G.B., de Feo, P.: Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans. J. Nutr. 1998; 128: 198–203
Watson, R.R., Mohs, M.E., Eskelson, C., Sampliner, R.E., Hartmann, B.: Identification of alcohol abuse and alcoholism with biological parameters. Alcohol. Clin. Exp. Res. 1986; 10: 364–385
Willner, I.R., Reuben, A.: Alcohol and the liver (review) Curr. Opin. Gastroenterol. 2005; 21: 323–330
Worner, T.M., Lieber C.S.: Perivenular fibrosis as precursor lesion of cirrhosis. J. Amer. Med. Ass. 1985; 254: 627–630
Xiong, S., She, H., Sung, C.K., Tsukamoto, H.: Iron-dependent activation of NF-kappa B in kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 2003; 30: 107–113
Zachara, B.A., Borowska, K., Koper, J., Rybakowski, J., Pilaczynska, E.: SelSelen-uund Zinkgehalte im Serum bei chronischen Alkoholikern. Z. Ges. Hygiene 1988; 34: 187–189
Zhou, Z.X., Wang, L.P., Song, Z.Y., Saari, J.T., McClain, C.J., Kang, Y.J.: Zurc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Amer. J. Pathol. 2005; 166: 1681–1690
Zieve, L.: Jaundice, hyperlipidemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann. Intern. Med. 1958; 48: 471–496
Zintzaras, E., Stefanidis, I., Santos, M., Vidal, F.: Do alcohol-metabolizing enzyme gene polymorplusms increase the risk of alcoholism and alcoholic liver disease. Hepatology 2006; 43: 352–361
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(2008). Alcohol-induced liver damage. In: Hepatology Textbook and Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76839-5_28
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