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SmartTransplantation - Allogeneic Stem Cell Transplantation as a Model for a Medical Expert System

  • Gerrit Meixner
  • Nancy Thiels
  • Ulrike Klein
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4799)

Abstract

Public health care has to make use of the potentials of IT to meet the enormous demands on patient management in the future. Embedding artificial intelligence in medicine may lead to an increase in quality and safety. One possibility in this respect is an expert system. Conditions for an expert system are structured data sources to extract relevant data for the proposed decision. Therefore the demonstrator ‘allo-tool’ was designed. The concept of introducing a ‘Medical decision support system based on the model of Stem Cell Transplantation’ was developed afterwards. The objectives of the system are (1) to improve patient safety (2) to support patient autonomy and (3) to optimize the workflow of medical personnel.

Keywords

Human-Computer Interaction in Health Care Usability of Medical Information Systems Human Aspects of Future Technologies in Health Care Cognitive Task Analysis Usability Engineering Stem cell transplantation Decision support system 

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References

  1. 1.
    Glossary of terms in Evidence-Based Medicine. Centre for Evidence-Based Medicine (last access: 2007-08-28), http://www.cebm.net/index.aspx?o=1116
  2. 2.
    Clarke, M., Hopewell, S., Chalmers, I.: Reports of clinical trials should begin and end with up-to-date systematic reviews of other relevant evidence: a status report. J. R. Soc. Med. 100(4), 187–190 (2007)CrossRefGoogle Scholar
  3. 3.
    Sneiderman, C.A., Demner-Fushman, D., Fiszman, M., Ide, N.C., Rindflesch, T.C.: Knowledge-Based Methods to Help Clinicians Find Answers in MEDLINE. J. Am. Med. Inform. Assoc. 2007  (2007)Google Scholar
  4. 4.
    Boulware, L.E., Marinopoulos, S., Phillips, K.A., et al.: Systematic review: the value of the periodic health evaluation. Ann. Intern. Med. 146(4), 289–300 (2007)Google Scholar
  5. 5.
    Hope, C., Overhage, J.M., Seger, A., et al.: A tiered approach is more cost effective than traditional pharmacist-based review for classifying computer-detected signals as adverse drug events. J. Biomed. Inform. 36(1-2), 92–98 (2003)CrossRefGoogle Scholar
  6. 6.
    Poley, M.J., Edelenbos, K.I., Mosseveld, M., et al.: Cost consequences of implementing an electronic decision support system for ordering laboratory tests in primary care: evidence from a controlled prospective study in the Netherlands. Clin. Chem. 53(2), 213–219 (2007)CrossRefGoogle Scholar
  7. 7.
    Bruynesteyn, K., Gant, V., McKenzie, C., et al.: cost-effectiveness analysis of caspofungin vs. liposomal amphotericin B for treatment of suspected fungal infections in the UK. Eur. J. Haematol. 78(6), 532–539 (2007)CrossRefGoogle Scholar
  8. 8.
    Shortliffe, E.H., Davis, R., Axline, S.G., Buchanan, B.G., Green, C.C., Cohen, S.N.: Computer-based consultations in clinical therapeutics: explanation and rule acquisition capabilities of the MYCIN system. Comput. Biomed. Res. 8(4), 303–320 (1975)CrossRefGoogle Scholar
  9. 9.
    Yu, V.L., Buchanan, B.G., Shortliffe, E.H., et al.: Evaluating the performance of a computer-based consultant. Comput. Programs Biomed. 9(1), 95–102 (1979)CrossRefGoogle Scholar
  10. 10.
    Shi, H., Lyons-Weiler, J.: Clinical decision modeling system. BMC Med. Inform. Decis. Mak. 7(1), 23 (2007)CrossRefGoogle Scholar
  11. 11.
    Montgomery, M., Cottler-Fox, M.: Mobilization and collection of autologous hematopoietic progenitor/stem cells. Clin. Adv. Hematol. Oncol. 5(2), 127–136 (2007)Google Scholar
  12. 12.
    Korbling, M., Champlin, R.: Peripheral blood progenitor cell transplantation: a replacement for marrow auto- or allografts. Stem. Cells 14(2), 185–195 (1996)CrossRefGoogle Scholar
  13. 13.
    Satwani, P., Morris, E., Bradley, M.B., Bhatia, M., et al.: Reduced intensity and non-myeloablative allogeneic stem cell transplantation in children and adolescents with malignant and non-malignant diseases. Pediatr Blood Cancer (2007)Google Scholar
  14. 14.
    Del, T.G., Satwani, P., Harrison, L., et al.: A pilot study of reduced intensity conditioning and allogeneic stem cell transplantation from unrelated cord blood and matched family donors in children and adolescent recipients. Bone. Marrow Transplant 33(6), 613–622 (2004)CrossRefGoogle Scholar
  15. 15.
    Neuburger, S., Maschmeyer, G.: Update on management of infections in cancer and stem cell transplant patients. Ann. Hematol. 85(6), 345–356 (2006)CrossRefGoogle Scholar
  16. 16.
    Afessa, B., Peters, S.G.: Major complications following hematopoietic stem cell transplantation. Semin Respir. Crit. Care Med. 27(3), 297–309 (2006)CrossRefGoogle Scholar
  17. 17.
    Shlomchik, W.D.: Graft-versus-host disease. Nat. Rev. Immunol. 7(5), 340–352 (2007)CrossRefGoogle Scholar
  18. 18.
    Zühlke, D.: Useware-Engineering für technische Systeme, Berlin (2004)Google Scholar
  19. 19.
    Bödcher, A.: Methodische Nutzungskontext-Analyse als Grundlage eines strukturierten USEWARE-Engineering-Prozesses. Fortschritt-Berichte pak, Band 14, Kaiserslautern: Technische Universität Kaiserslautern (2007)Google Scholar
  20. 20.
    Reuther, A.: useML – Systematische Entwicklung von Maschinenbediensystemen mit XML. Fortschritt-Berichte pak, Band 8, Kaiserslautern: Technische Universität Kaiserslautern (2003)Google Scholar
  21. 21.
    Nielsen, J.: Usability Engineering. Morgan Kaufmann, San Francisco (1994)Google Scholar
  22. 22.
    Dix, A., Finlay, J., Abowd, G., Beale, R.: Human-Computer Interaction, 3rd edn. Pearson, London (2004)Google Scholar
  23. 23.
    Holzinger, A.: Usability Engineering for Software Developers. Communications of the ACM 48(1), 71–74 (2005)CrossRefGoogle Scholar
  24. 24.
    Shneiderman, B.: Designing the User Interface, 3rd edn. Addison-Wesley, Reading (1997)Google Scholar
  25. 25.
    Norman, D.: The Design of Everyday Things, Currency (1990)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Gerrit Meixner
    • 1
  • Nancy Thiels
    • 2
  • Ulrike Klein
    • 3
  1. 1.University of KaiserslauternGermany
  2. 2.German Research Center for Artificial Intelligence (DFKI)Germany
  3. 3.University of HeidelbergGermany

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