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Late Effects of Hematopoietic Cell Transplantation Including Total Body Irradiation

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ALERT • Adverse Late Effects of Cancer Treatment

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

It is estimated that over 50,000 autologous or allogeneic hematopoietic cell transplants (HCT) are performed worldwide every year and that number continues to grow. Total body irradiation (TBI) began as and remains an integral part of the transplantation conditioning process in addition to high-dose chemotherapy (HD-CTX). In addition to its role as a tumor cytotoxic agent, the eradication of host hematopoietic and immunological cells is equally important particularly for allogeneic transplants. As the number of HCT increases worldwide and the survival continues to improve, the late deleterious consequences of HCT will increasingly become paramount. The late effects of HCT and in particular, TBI are manifest in practically every organ system and may have significant impact on the quality of life of surviving patients years after transplantation. Patients must be followed meticulously and appropriate interventions executed to minimize the impact of late treatment effects. This chapter examines the acute and long-term consequences of TBI in combination with various preparative regimens by specific organ sites.

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Authors and Affiliations

  1. Departments of Radiation Oncology, Pediatrics, and Neurological Surgery, University of Washington, Seattle, WA, USA

    James G. Douglas

  2. Associate Professor of Pediatrics, University of Washington, Seattle, WA, USA

    Debra L. Friedman

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  1. James G. Douglas
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  2. Debra L. Friedman
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Correspondence to Debra L. Friedman .

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Editors and Affiliations

  1. Dept. Radiation Oncology, University of Rochester Medical Center James P. Wilmot Cancer Ctr., Rochester, New York, USA

    Philip Rubin

  2. Department of Radiation Oncology, University of Rochester Medical Center James P. Wilmot Cancer Ctr., Rochester, New York, USA

    Louis S. Constine

  3. Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, USA

    Lawrence B. Marks

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Douglas, J.G., Friedman, D.L. (2014). Late Effects of Hematopoietic Cell Transplantation Including Total Body Irradiation. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_25

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