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Abbreviations
- ACEI:
-
Angiotensin-converting enzyme inhibitors
- AV:
-
Atrioventricular
- NT-proBNP:
-
Brain natriuretic peptide and N-terminal fragment
- CAC:
-
Coronary artery calcification
- EBCTCG:
-
Early breast cancer trialists’ collaborative group
- EGFR:
-
Epidermal growth factor receptor
- HR:
-
Hazard ratios
- HER2:
-
Human epidermal growth factor receptor 2
- LAD:
-
Left anterior descending artery
- LCX:
-
Left circumflex artery
- LSS:
-
Life span study
- MR:
-
Magnetic resonance
- NTCP:
-
Normal tissue complication probability
- PCI:
-
Percutaneous coronary intervention
- PDA:
-
Posterior descending artery
- RT:
-
Radiation treatment
- RCA:
-
Right coronary artery
- RMA:
-
Right marginal artery
- SE:
-
Standard error
- SIR:
-
Standardized incidence ratios
- SEER:
-
Surveillance, epidemiology and end-results cancer registries
- VEGF:
-
Vascular endothelial growth factor
References
Adams MJ, Lipshultz SE (2005) Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and prevention. Pediatr Blood Cancer 44(7):600–606
Adams MJ, Lipshultz SE, Schwartz C et al (2003) Radiation-associated cardiovascular disease: manifestations and management. Semin Radiat Oncol 13(3):346–356
Adams MJ, Lipsitz SR, Colan SD et al (2004) Cardiovascular status in long-term survivors of Hodgkin’s disease treated with chest radiotherapy. J Clin Oncol 22(15):3139–3148
AGIR (2010) Circulatory Disease Risk. Report of the Independent Advisory Group on Ionising Radiation. Doc. HPA, RCE-16. The Health Protection Agency, Chilton, UK
Akhtar SS, Salim KP, Bano ZA (1993) Symptomatic cardiotoxicity with high-dose 5-fluorouracil infusion: a prospective study. Oncology 50(6):441–444
Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med 23(5):469–480
Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 120(16):1640–1645
Albini A, Pennesi G, Donatelli F et al (2010) Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention. J Natl Cancer Inst 102(1):14–25
Aleman BM, van den Belt-Dusebout AW, Klokman WJ et al (2003) Long-term cause-specific mortality of patients treated for Hodgkin’s disease. J Clin Oncol 21(18):3431–3439
Aleman BM, van den Belt-Dusebout AW, De Bruin ML et al (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109(5):1878–1886
Andersen R, Wethal T, Gunther A et al (2010) Relation of coronary artery calcium score to premature coronary artery disease in survivors >15 years of Hodgkin’s lymphoma. Am J Cardiol 105(2):149–152
Annaloro C, Usardi P, Airaghi L et al (2008) Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation. Bone Marrow Transplant 41(9):797–804
Anversa P, Leri A, Rota M et al (2007) Concise review: stem cells, myocardial regeneration, and methodological artifacts. Stem Cells 25(3):589–601
Arbuck SG, Strauss H, Rowinsky E et al (1993) A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr 15:117–130
Arola OJ, Saraste A, Pulkki K et al (2000) Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis. Cancer Res 60(7):1789–1792
Atallah E, Durand JB, Kantarjian H et al (2007) Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood 110(4):1233–1237
Azizi M, Chedid A, Oudard S (2008) Home blood-pressure monitoring in patients receiving sunitinib. N Engl J Med 358(1):95–97
Bakx JC, Veldstra MI, van den Hoogen HM et al (2001) Blood pressure and cardiovascular morbidity and mortality in a Dutch population: the Nijmegen cohort study. Prev Med 32(2):142–147
Barbey JT, Pezzullo JC, Soignet SL (2003) Effect of arsenic trioxide on QT interval in patients with advanced malignancies. J Clin Oncol 21(19):3609–3615
Barry E, Alvarez JA, Scully RE et al (2007) Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management. Expert Opin Pharmacother 8(8):1039–1058
Bertog SC, Thambidorai SK, Parakh K et al (2004) Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy. J Am Coll Cardiol 43(8):1445–1452
Blanco JG, Leisenring WM, Gonzalez-Covarrubias VM et al (2008) Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. Cancer 112(12):2789–2795
Boivin JF, Hutchison GB, Lubin JH et al (1992) Coronary artery disease mortality in patients treated for Hodgkin’s disease. Cancer 69(5):1241–1247
Bovelli D, Plataniotis G, Roila F (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines. Ann Oncol 21(Suppl 5):v277–v282
Bowers DC, McNeil DE, Liu Y et al (2005) Stroke as a late treatment effect of Hodgkin’s disease: a report from the childhood cancer survivor study. J Clin Oncol 23(27):6508–6515
Bowers DC, Liu Y, Leisenring W et al (2006) Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the childhood cancer survivor study. J Clin Oncol 24(33):5277–5282
Braverman AC, Antin JH, Plappert MT et al (1991) Cyclophosphamide cardiotoxicity in bone marrow transplantation: a prospective evaluation of new dosing regimens. J Clin Oncol 9(7):1215–1223
Breccia M (2011) Is imatinib-related cardiotoxicity still an open issue? Leuk Res 35(1):34–35
Brosius FC III, Waller BF, Roberts WC (1981) Radiation heart disease. Analysis of 16 young (aged 15 to 33 years) necropsy patients who received over 3,500 rads to the heart. Am J Med 70(3):519–530
Burman C, Kutcher GJ, Emami B et al (1991) Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys 21(1):123–135
Burstein HJ, Elias AD, Rugo HS et al (2008) Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 26(11):1810–1816
Byhardt R, Brace K, Ruckdeschel J et al (1975) Dose and treatment factors in radiation-related pericardial effusion associated with the mantle technique for Hodgkin’s disease. Cancer 35(3):795–802
Caplice NM, Doyle B (2005) Vascular progenitor cells: origin and mechanisms of mobilization, differentiation, integration, and vasculogenesis. Stem Cells Dev 14(2):122–139
Cardinale D, Sandri MT, Martinoni A et al (2000) Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J Am Coll Cardiol 36(2):517–522
Cardinale D, Colombo A, Colombo N (2006a) Acute coronary syndrome induced by oral capecitabine. Can J Cardiol 22(3):251–253
Cardinale D, Colombo A, Sandri MT et al (2006b) Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation 114(23):2474–2481
Cardinale D, Colombo A, Lamantia G et al (2010) Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55(3):213–220
Carlson RG, Mayfield WR, Normann S et al (1991) Radiation-associated valvular disease. Chest 99(3):538–545
Carr ZA, Land CE, Kleinerman RA et al. (2005) Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys 61(3):842–850
Carmel RJ, Kaplan HS (1976) Mantle irradiation in Hodgkin’s disease. An analysis of technique, tumor eradication, and complications. Cancer 37(6):2813–2825
Chaosuwannakit N, D’Agostino R Jr, Hamilton CA et al (2010) Aortic stiffness increases upon receipt of anthracycline chemotherapy. J Clin Oncol 28(1):166–172
Cheitlin MD, Armstrong WF, Aurigemma GP et al (2003) ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/ASE committee to update the 1997 guidelines for the clinical application of echocardiography). Circulation 108(9):1146–1162
Chen MH (2009) Cardiac dysfunction induced by novel targeted anticancer therapy: an emerging issue. Curr Cardiol Rep 11(3):167–174
Chen MH, Chuang ML, Bornstein BA et al (1997) Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation 96(10):3269–3272
Chen MH, Cash EP, Danias PG et al (2002) Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Cardiovasc Magn Reson 4(2):265–271
Chen MH, Kerkela R, Force T (2008) Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 118(1):84–95
Chen MH, Colan SD, Diller L (2011) Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 108(5):619–628
Cheng H, Force T (2010) Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res 106(1):21–34
Chobanian AV, Bakris GL, Black HR et al (2003) Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42(6):1206–1252
Chowdhury UK, Subramaniam GK, Kumar AS et al (2006) Pericardiectomy for constrictive pericarditis: a clinical, echocardiographic, and hemodynamic evaluation of two surgical techniques. Ann Thorac Surg 81(2):522–529
Chu TF, Rupnick MA, Kerkela R et al (2007) Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370(9604):2011–2019
Clarke M, Collins R, Darby S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087–2106
Cobleigh MA, Langmuir VK, Sledge GW et al (2003) A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 30(5 Suppl 16):117–124
Cohn KE, Stewart JR, Fajardo LF et al (1967) Heart disease following radiation. Medicine (Baltimore) 46(3):281–298
Coronary Artery Surgery Study (CASS) (1983) A randomized trial of coronary artery bypass surgery. Survival data. Circulation 68(5):939–950
Correa CR, Litt HI, Hwang WT et al (2007) Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. J Clin Oncol 25(21):3031–3037
Cosset JM, Henry-Amar M, Girinski T et al (1988) Late toxicity of radiotherapy in Hodgkin’s disease. The role of fraction size. Acta Oncol 27(2):123–129
Cosset JM, Henry-Amar M, Meerwaldt JH (1991) Long-term toxicity of early stages of Hodgkin’s disease therapy: the EORTC experience. EORTC lymphoma cooperative group. Ann Oncol 2(Suppl 2):77–82
Cowen D, Gonzague-Casabianca L, Brenot-Rossi I et al. (1998) Thallium-201 perfusion scintigraphy in the evaluation of late myocardial damage in left-side breast cancer treated with adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 41(4):809–815
Crone SA, Zhao YY, Fan L et al (2002) ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 8(5):459–465
Cuzick J, Stewart HJ, Peto R et al (1988) Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. Recent Results Cancer Res 111:108–129
Cuzick J, Stewart H, Rutqvist L et al (1994) Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 12(3):447–453
Czaykowski PM, Moore MJ, Tannock IF (1998) High risk of vascular events in patients with urothelial transitional cell carcinoma treated with cisplatin based chemotherapy. J Urol 160(6 Pt 1):2021–2024
Darby S, McGale P, Peto R et al (2003) Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90,000 Swedish women. BMJ 326(7383):256–257
Darby SC, McGale P, Taylor CW et al (2005) Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol 6(8):557–565
Darby SC, Cutter DJ, Boerma M et al (2010) Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys 76(3):656–665
De Angelis A, Piegari E, Cappetta D et al (2010) Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121(2):276–292
De Bruin ML, Dorresteijn LD (2009) van’t Veer MB et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst 101(13):928–937
De Forni M, Malet-Martino MC, Jaillais P et al (1992) Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study. J Clin Oncol 10(11):1795–1801
De Haas EC, Oosting SF, Lefrandt JD et al (2010) The metabolic syndrome in cancer survivors. Lancet Oncol 11(2):193–203
Demetri GD, van Oosterom AT, Garrett CR et al (2006) Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368(9544):1329–1338
Deng S, Wojnowski L (2007) Genotyping the risk of anthracycline-induced cardiotoxicity. Cardiovasc Toxicol 7(2):129–134
Di Paolo A, Danesi R, Falcone A et al (2001) Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients. Ann Oncol 12(9):1301–1306
Doroshow JH, Locker GY, Myers CE (1980) Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 65(1):128–135
Dorresteijn LD, Kappelle AC, Boogerd W et al (2002) Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years. J Clin Oncol 20(1):282–288
Einhorn D, Reaven GM, Cobin RH et al (2003) American college of endocrinology position statement on the insulin resistance syndrome. Endocr Pract 9(3):237–252
Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21(1):109–122
Erickson SL, O’Shea KS, Ghaboosi N et al (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124(24):4999–5011
Eriksson F, Gagliardi G, Liedberg A et al. (2000) Long-term cardiac mortality following radiation therapy for Hodgkin's disease: analysis with the relative seriality model. Radiother Oncol 55(2):153–162
Escudier B, Eisen T, Stadler WM et al (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356(2):125–134
Evans ES, Prosnitz RG, Yu X et al (2006) Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer. Int J Radiat Oncol Biol Phys 66(4):1125–1134
Ewer MS, O’Shaughnessy JA (2007) Cardiac toxicity of trastuzumab-related regimens in HER2-overexpressing breast cancer. Clin Breast Cancer 7(8):600–607
Executive Summary of the Third Report of the National cholesterol Education Program (NCEP) Expert Panel on Detection (2001) Evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J Am Med Assoc 285:2486–2497
Fahdi IE, Gaddam V, Saucedo JF et al (2004) Bradycardia during therapy for multiple myeloma with thalidomide. Am J Cardiol 93(8):1052–1055
Fainaru O, Adini I, Benny O et al (2008) Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 22(10):3728–3735
Fajardo LF, Berthrong M, Anderson RE (2001) Radiation pathology. Oxford University Press, New York
Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer (2000): an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet 355(9217):1757–1770
Floyd JD, Nguyen DT, Lobins RL et al (2005) Cardiotoxicity of cancer therapy. J Clin Oncol 23(30):7685–7696
Force T, Krause DS, Van Etten RA (2007) Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 7(5):332–344
Francis GS, Wilson Tang WH, Sonnenblick EM (2004) The pathophysiology of heart failure. In: Fuster V, Alexander RW, ‘O’Rourke RA (eds) Hurst’s the heart. MsGraw-Hill, New York, pp 697–792
Frickhofen N, Beck FJ, Jung B et al (2002) Capecitabine can induce acute coronary syndrome similar to 5-fluorouracil. Ann Oncol 13(5):797–801
Gagliardi G, Lax I, Ottolenghi A et al (1996) Long-term cardiac mortality after radiotherapy of breast cancer—application of the relative seriality model. Br J Radiol 69(825):839–846
Gagliardi G, Constine LS, Moiseenko V et al (2010) Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys 76(3 Suppl):S77–S85
Galper SL, Yu JB, Mauch PM et al (2010) Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood 116:2237–2240
Gaya AM, Ashford RF (2005) Cardiac complications of radiation therapy. Clin Oncol (R Coll Radiol) 17(3):153–159
Gianni L, Salvatorelli E, Minotti G (2007) Anthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanes. Cardiovasc Toxicol 7(2):67–71
Giantris A, Abdurrahman L, Hinkle A et al (1998) Anthracycline-induced cardiotoxicity in children and young adults. Crit Rev Oncol Hematol 27(1):53–68
Giordano SH, Kuo YF, Freeman JL et al (2005) Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst 97(6):419–424
Girinsky T, Cordova A, Rey A et al (2000) Thallium-201 scintigraphy is not predictive of late cardiac complications in patients with Hodgkin’s disease treated with mediastinal radiation. Int J Radiat Oncol Biol Phys 48(5):1503–1506
Glanzmann C, Huguenin P, Lutolf UM et al (1994) Cardiac lesions after mediastinal irradiation for Hodgkin’s disease. Radiother Oncol 30(1):43–54
Glanzmann C, Kaufmann P, Jenni R et al (1998) Cardiac risk after mediastinal irradiation for Hodgkin’s disease. Radiother Oncol 46(1):51–62
Goldberg MA, Antin JH, Guinan EC et al (1986) Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor. Blood 68(5):1114–1118
Goormaghtigh E, Huart P, Praet M et al (1990) Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity. Biophys Chem 35(2–3):247–257
Gottdiener JS, Appelbaum FR, Ferrans VJ et al (1981) Cardiotoxicity associated with high-dose cyclophosphamide therapy. Arch Intern Med 141(6):758–763
Grundy SM, Cleeman JI, Daniels SR et al (2005) Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 112(17):2735–2752
Guarneri V, Lenihan DJ, Valero V et al (2006) Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson cancer center experience. J Clin Oncol 24(25):4107–4115
Guglin M, Cutro R, Mishkin JD (2008) Trastuzumab-induced cardiomyopathy. J Cardiac Fail 14(5):437–444
Gustavsson A, Eskilsson J, Landberg T et al (1990) Late cardiac effects after mantle radiotherapy in patients with Hodgkin’s disease. Ann Oncol 1(5):355–363
Gyenes G, Fornander T, Carlens P et al. (1994) Morbidity of ischemic heart disease in early breast cancer 15–20 years after adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 28(5):1235–1241
Gyenes G, Fornander T, Carlens P et al. (1996) Myocardial damage in breast cancer patients treated with adjuvant radiotherapy: a prospective study. Int J Radiat Oncol Biol Phys 36(4):899–905
Haberl R, Becker A, Leber A et al (2001) Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: results of 1,764 patients. J Am Coll Cardiol 37(2):451–457
Haider AW, Larson MG, Franklin SS et al (2003) Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham heart study. Ann Intern Med 138(1):10–16
Halyard MY, Pisansky TM, Dueck AC et al (2009) Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerability and adverse event data from the NCCTG Phase III Trial N9831. J Clin Oncol 27(16):2638–2644
Hampton T (2010) Cancer therapy can be hard on the heart: researchers aim to explain—and avoid—cardiotoxicity. JAMA 303(11):1019–1020
Hancock SL, Hoppe RT (1996) Long-term complications of treatment and causes of mortality after Hodgkin’s disease. Semin Radiat Oncol 6(3):225–242
Hancock SL, Donaldson SS, Hoppe RT (1993a) Cardiac disease following treatment of Hodgkin’s disease in children and adolescents. J Clin Oncol 11(7):1208–1215
Hancock SL, Tucker MA, Hoppe RT (1993b) Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease. JAMA 270(16):1949–1955
Harris EE, Correa C, Hwang WT et al (2006) Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 24:4100–4106
Hatfield A, Owen S, Pilot PR (2007) In reply to ‘cardiotoxicity of the cancer therapeutic agent imatinib mesylate’. Nat Med 13(1):13–16
Haugnes HS, Aass N, Fossa SD et al (2007) Components of the metabolic syndrome in long-term survivors of testicular cancer. Ann Oncol 18(2):241–248
Haynes JC, Machtay M, Weber RS et al (2002) Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation. Laryngoscope 112(10):1883–1887
Heidenreich PA, Hancock SL, Lee BK et al (2003) Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol 42(4):743–749
Heidenreich PA, Schnittger I, Strauss HW et al (2007) Screening for coronary artery disease after mediastinal irradiation for Hodgkin’s disease. J Clin Oncol 25(1):43–49
Herman EH, Zhang J, Lipshultz SE et al (1999) Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin. J Clin Oncol 17(7):2237–2243
Herman EH, Zhang J, Rifai N et al (2001) The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity. Cancer Chemother Pharmacol 48(4):297–304
Hojris I, Overgaard M, Christensen JJ et al (1999) Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy committee of the Danish breast cancer cooperative group. Lancet 354(9188):1425–1430
Hojris I, Sand NP, Andersen J et al. (2000) Myocardial perfusion imaging in breast cancer patients treated with or without post-mastectomy radiotherapy. Radiother Oncol 55(2):163–172
Hooning MJ, Botma A, Aleman BM et al (2007) Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst 99(5):365–375
Hoving S, Heeneman S et al (2008) Single-dose and fractionated irradiation promote initiation and progression of artherosclerosis and induce an inflammatory plaque phenotype in Apo(-/-) mice. Int J Radiat Oncol Biol Phys 71(3):848–857
Huang SY, Chang CS, Tang JL et al (1998) Acute and chronic arsenic poisoning associated with treatment of acute promyelocytic leukaemia. Br J Haematol 103(4):1092–1095
Hull MC, Morris CG, Pepine CJ et al (2003) Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy. JAMA 290(21):2831–2837
Hunt SA, Abraham WT, Chin MH et al (2009) 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American college of cardiology foundation/american heart association task force on practice guidelines: developed in collaboration with the international society for heart and lung transplantation. Circulation 119(14):e391–e479
Hurwitz H, Fehrenbacher L, Novotny W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350(23):2335–2342
ICRP Report (2012) Early and late effects of radiation in normal tissues and organs: threshold doses for tissue reactions in a radiation protection context (in press) Ref Type: Report http://www.icrp.org/page.asp?id=116
Imai K, Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6(9):714–727
Izumiya Y, Shiojima I, Sato K et al (2006) Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension 47(5):887–893
Jensen SA, Sorensen JB (2006) Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine. Cancer Chemother Pharmacol 58(4):487–493
Johnson DH, Fehrenbacher L, Novotny WF et al (2004) Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22(11):2184–2191
Jones LW, Haykowsky MJ, Swartz JJ et al (2007) Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol 50:1435–1441
Kabbinavar FF, Schulz J, McCleod M et al (2005) Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 23(16):3697–3705
Kamba T, McDonald DM (2007) Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer 96(12):1788–1795
Kang YJ (2001) Molecular and cellular mechanisms of cardiotoxicity. Environ Health Perspect 109(Suppl 1):27–34
Kannel WB (1996) Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 275(20):1571–1576
Kaur A, Yu SS, Lee AJ et al (2003) Thalidomide-induced sinus bradycardia. Ann Pharmacother 37(7–8):1040–1043
Keefe DL (2001) Anthracycline-induced cardiomyopathy. Semin Oncol 28(4 Suppl 12):2–7
Keefe DL, Roistacher N, Pierri MK (1993) Clinical cardiotoxicity of 5-fluorouracil. J Clin Pharmacol 33(11):1060–1070
Kerkela R, Grazette L, Yacobi R et al (2006) Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 12(8):908–916
Kerkela R, Woulfe KC, Durand JB et al (2009) Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci 2(1):15–25
Khakoo AY, Kassiotis CM, Tannir N et al (2008) Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer 112(11):2500–2508
Kilickap S, Abali H, Celik I (2003) Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 21(18):3542
Klocke FJ, Baird MG, Lorell BH et al (2003) ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/ASNC committee to revise the 1995 guidelines for the clinical use of cardiac radionuclide imaging). Circulation 108(11):1404–1418
Kohne CH, Thuss-Patience P, Friedrich M et al (1998) Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity. Br J Cancer 77(6):973–977
Korreman SS, Pedersen AN, Aarup LR et al (2006) Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer. Int J Radiat Oncol Biol Phys 65(5):1375–1380
Kosmas C, Kallistratos MS, Kopterides P et al (2008) Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study. J Cancer Res Clin Oncol 134(1):75–82
Kutcher GJ, Burman C (1989) Calculation of complication probability factors for non-uniform normal tissue irradiation: the effective volume method. Int J Radiat Oncol Biol Phys 16(6):1623–1630
Labianca R, Beretta G, Clerici M et al (1982) Cardiac toxicity of 5-fluorouracil: a study on 1083 patients. Tumori 68(6):505–510
Lauk S, Kiszel Z, Buschmann J et al (1985) Radiation-induced heart disease in rats. Int J Radiat Oncol Biol Phys 11(4):801–808
Lee KF, Simon H, Chen H et al (1995a) Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378(6555):394–398
Lee SP, Leu MY, Smathers JB et al (1995b) Biologically effective dose distribution based on the linear quadratic model and its clinical relevance. Int J Radiat Oncol Biol Phys 33(2):375–389
Lee CK, Aeppli D, Nierengarten ME (2000) The need for long-term surveillance for patients treated with curative radiotherapy for Hodgkin’s disease: university of Minnesota experience. Int J Radiat Oncol Biol Phys 48(1):169–179
Lejemtel TH, Sonnenblick EH, Frishman WH (2004) Diagnosis and management of heart failure. In: Fuster V, Alexander RW, ‘O’Rourke RA (eds) Hurst’s the heart. McGraw-Hill, New York, pp 723–762
Leonard RC, Williams S, Tulpule A et al (2009) Improving the therapeutic index of anthracycline chemotherapy: focus on liposomal doxorubicin (Myocet). Breast 18(4):218–224
Lind PA, Pagnanelli R, Marks LB et al (2003) Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution. Int J Radiat Oncol Biol Phys 55(4):914–920
Ling LH, Oh JK, Schaff HV et al (1999) Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy. Circulation 100(13):1380–1386
Lipshultz SE, Adams MJ (2010) Cardiotoxicity after childhood cancer: beginning with the end in mind. J Clin Oncol 28(8):1276–1281
Lipshultz SE, Sallan SE (1993) Cardiovascular abnormalities in long-term survivors of childhood malignancy. J Clin Oncol 11(7):1199–1203
Lipshultz SE, Colan SD, Gelber RD et al (1991) Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. N Engl J Med 324(12):808–815
Lipshultz SE, Lipsitz SR, Mone SM et al (1995) Female sex and drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer. N Engl J Med 332(26):1738–1743
Lipshultz SE, Grenier MA, Colan SD (1999) Doxorubicin-induced cardiomyopathy. N Engl J Med 340(8):653–654
Lipshultz SE, Giantris AL, Lipsitz SR et al (2002) Doxorubicin administration by continuous infusion is not cardioprotective: the Dana-Farber 91–01 acute lymphoblastic leukemia protocol. J Clin Oncol 20(6):1677–1682
Lipshultz SE, Rifai N, Dalton VM et al (2004) The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351(2):145–153
Lipshultz SE, Alvarez JA, Scully RE (2008) Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart 94(4):525–533
Little MP (2009) Cancer and non-cancer effects in Japanese atomic bomb survivors. J Radiol Prot 29(2A):A43–A59
Little MP (2010) Exposure to radiation and higher risk of circulatory disease. BMJ 340:b4326
Little MP, Tawn EJ, Tzoulaki I et al (2010) Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms. Radiat Environ Biophys 49(2):139–153
Lu HM, Cash E, Chen MH et al (2000) Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys 47(4):895–904
Lu L, Payvandi F, Wu L et al (2009) The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res 77(2):78–86
Lund MB, Ihlen H, Voss BM et al (1996) Increased risk of heart valve regurgitation after mediastinal radiation for Hodgkin’s disease: an echocardiographic study. Heart 75(6):591–595
Luwaert RJ, Descamps O, Majois F et al (1991) Coronary artery spasm induced by 5-fluorouracil. Eur Heart J 12(3):468–470
Lyman JT (1985) Complication probability as assessed from dose-volume histograms. Radiat Res Suppl 8:S13–S19
Maitland ML, Bakris GL, Black HR et al (2010) Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. J Natl Cancer Inst 102(9):596–604
Majhail NS, Flowers ME, Ness KK et al (2009) High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 43(1):49–54
Manojlovic N, Babic D, Stojanovic S et al (2008) Capecitabine cardiotoxicity—case reports and literature review. Hepatogastroenterology 55(85):1249–1256
Marks LB, Yu X, Prosnitz RG et al (2005) The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 63(1):214–223
Martel MK, Sahijdak WM, Ten Haken RK et al (1998) Fraction size and dose parameters related to the incidence of pericardial effusions. Int J Radiat Oncol Biol Phys 40(1):155–161
Martin M, Pienkowski T, Mackey J et al (2005) Adjuvant docetaxel for node-positive breast cancer. N Engl J Med 352(22):2302–2313
Marty M, Cognetti F, Maraninchi D et al (2005) Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 23(19):4265–4274
Matsumura T, Wolff K, Petzelbauer P (1997) Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 158(7):3408–3416
McArthur HL, Chia S (2007) Cardiotoxicity of trastuzumab in clinical practice. N Engl J Med 357(1):94–95
McCray R, Francis GS, Fuster V (2009) Diagnosis and Management of Heart Failure. In: O’Rourke R, Walsh R, Fuster V (eds)
McGuire WP, Rowinsky EK, Rosenshein NB et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med 111(4):273–279
Meyer CC, Calis KA, Burke LB et al (1997) Symptomatic cardiotoxicity associated with 5-fluorouracil. Pharmacotherapy 17(4):729–736
Miller KD, Chap LI, Holmes FA et al (2005) Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23(4):792–799
Miller K, Wang M, Gralow J et al (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357(26):2666–2676
Minotti G, Menna P, Salvatorelli E et al (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56(2):185–229
Miura K, Daviglus ML, Dyer AR et al (2001) Relationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: the Chicago heart association detection project in industry. Arch Intern Med 161(12):1501–1508
Morandi P, Ruffini PA, Benvenuto GM et al (2005) Cardiac toxicity of high-dose chemotherapy. Bone Marrow Transplant 35(4):323–334
Morton DL, Glancy DL, Joseph WL et al (1973) Management of patients with radiation-induced pericarditis with effusion: a note on the development of aortic regurgitation in two of them. Chest 64(3):291–297
Mosca L, Banka CL, Benjamin EJ et al (2007) Evidence-based guidelines for cardiovascular disease prevention in women: 2007 Update. J Am Coll Cardiol 49:1230–1250
Moser EC, Noordijk EM, van Leeuwen FE et al (2006) Long-term risk of cardiovascular disease after treatment for aggressive non-Hodgkin lymphoma. Blood 107(7):2912–2919
Motzer RJ, Michaelson MD, Redman BG et al (2006a) Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24(1):16–24
Motzer RJ, Rini BI, Bukowski RM et al (2006b) Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295(21):2516–2524
Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356(2):115–124
Mulrooney DA, Yeazel MW, Kawashima T et al (2009) Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the childhood cancer survivor study cohort. BMJ 339:b4606
Myrehaug S, Pintilie M, Tsang R et al (2008) Cardiac morbidity following modern treatment for Hodgkin lymphoma: supra-additive cardiotoxicity of doxorubicin and radiation therapy. Leuk Lymphoma 49(8):1486–1493
Myrehaug S, Pintilie M, Yun L et al (2010) A population-based study of cardiac morbidity among Hodgkin lymphoma patients with pre-existing heart disease. Blood 116:2237–2240
Ng M, Cunningham D, Norman AR (2005) The frequency and pattern of cardiotoxicity observed with capecitabine used in conjunction with oxaliplatin in patients treated for advanced colorectal cancer (CRC). Eur J Cancer 41(11):1542–1546
Noori A, Lindenfeld J, Wolfel E et al (2000) Beta-blockade in adriamycin-induced cardiomyopathy. J Cardiac Fail 6(2):115–119
Nuver J, Smit AJ, van der Meer J et al (2005) Acute chemotherapy-induced cardiovascular changes in patients with testicular cancer. J Clin Oncol 23(36):9130–9137
Ohnishi K, Yoshida H, Shigeno K et al (2002) Arsenic trioxide therapy for relapsed or refractory Japanese patients with acute promyelocytic leukemia: need for careful electrocardiogram monitoring. Leukemia 16(4):617–622
Olsen EA, Kim YH, Kuzel TM et al (2007) Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 25(21):3109–3115
Ozcelik C, Erdmann B, Pilz B et al (2002) Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A 99(13):8880–8885
Pai VB, Nahata MC (2000) Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf 22(4):263–302
Pakala R, Leborgne L, Cheneau E et al (2003) Radiation-induced atherosclerotic plaque progression in a hypercholesterolemic rabbit: a prospective vulnerable plaque model? Cardiovasc Radiat Med 4(3):146–151
Palazzuoli A, Gallotta M, Quatrini I et al (2010) Natriuretic peptides (BNP and NT-proBNP): measurement and relevance in heart failure. Vasc Health Risk Manag 6:411–418
Pande A, Lombardo J, Spangenthal E et al (2007) Hypertension secondary to anti-angiogenic therapy: experience with bevacizumab. Anticancer Res 27(5B):3465–3470
Paszat LF, Mackillop WJ, Groome PA et al (1998) Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol 16(8):2625–2631
Patel DA, Kochanski J, Suen AW et al (2006) Clinical manifestations of noncoronary atherosclerotic vascular disease after moderate dose irradiation. Cancer 106(3):718–725
Perez EA, Suman VJ, Davidson NE et al (2008a) Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the north central cancer treatment group N9831 adjuvant breast cancer trial. J Clin Oncol 26(8):1231–1238
Perez EA, Koehler M, Byrne J et al (2008b) Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 83(6):679–686
Piedbois P, Becquemin JP, Blanc I et al (1990) Arterial occlusive disease after radiotherapy: a report of fourteen cases. Radiother Oncol 17(2):133–140
Piovaccari G, Ferretti RM, Prati F et al (1995) Cardiac disease after chest irradiation for Hodgkin’s disease: incidence in 108 patients with long follow-up. Int J Cardiol 49(1):39–43
Preston DL, Shimizu Y, Pierce DA et al (2003) Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997. Radiat Res 160(4):381–407
Quezado ZM, Wilson WH, Cunnion RE et al (1993) High-dose ifosfamide is associated with severe, reversible cardiac dysfunction. Ann Intern Med 118(1):31–36
Reinders JG, Heijmen BJ, Olofsen-van Acht MJ et al (1999) Ischemic heart disease after mantlefield irradiation for Hodgkin’s disease in long-term follow-up. Radiother Oncol 51(1):35–42
Rezkalla S, Kloner RA, Ensley J et al (1989) Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study. J Clin Oncol 7(4):509–514
Robben NC, Pippas AW, Moore JO (1993) The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy. Cancer 71(2):493–509
Rodeghiero F, Elice F (2003) Thalidomide and thrombosis. Pathophysiol Haemost Thromb 33(Suppl 1):15–18
Romond EH, Perez EA, Bryant J et al (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353(16):1673–1684
Rose G, Baxter PJ, Reid DD et al (1978) Prevalence and prognosis of electrocardiographic findings in middle-aged men. Br Heart J 40(6):636–643
Rowinsky EK, McGuire WP, Guarnieri T et al (1991) Cardiac disturbances during the administration of taxol. J Clin Oncol 9(9):1704–1712
Rubin P, Casarett GW (1968) Clinical Radiation Pathology. Philadelphia, WB Saunders
Rutqvist LE, Johansson H (1990) Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish cancer registry. Br J Cancer 61(6):866–868
Saif MW, Tomita M, Ledbetter L et al (2008) Capecitabine-related cardiotoxicity: recognition and management. J Support Oncol 6(1):41–48
Sasson Z, Morgan CD, Wang B et al (1994) 5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. Can J Cardiol 10(8):861–864
Scappaticci FA, Skillings JR, Holden SN et al (2007) Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 99(16):1232–1239
Schnetzler B, Popova N, Collao LC et al (2001) Coronary spasm induced by capecitabine. Ann Oncol 12(5):723–724
Schober C, Papageorgiou E, Harstrick A et al (1993) Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. Cancer 72(7):2242–2247
Schomig K, Ndrepepa G, Mehilli J et al (2007) Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement. Catheter Cardiovasc Interv 70(3):359–365
Schultz-Hector S (1992) Radiation-induced heart disease: review of experimental data on dose response and pathogenesis. Int J Radiat Biol 61(2):149–160
Schultz-Hector S, Trott KR (2007) Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys 67(1):10–18
Scott AS, Parr LA, Johnstone PA (2009) Risk of cerebrovascular events after neck and supraclavicular radiotherapy: a systematic review. Radiother Oncol 90(2):163–165
Seddon B, Cook A, Gothard L et al (2002) Detection of defects in myocardial perfusion imaging in patients with early breast cancer treated with radiotherapy. Radiother Oncol 64(1):53–63
Seidman A, Hudis C, Pierri MK et al (2002) Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 20(5):1215–1221
Senkus-Konefka E, Jassem J (2007) Cardiovascular effects of breast cancer radiotherapy. Cancer Treat Rev 33(6):578–593
Sereno M, Brunello A, Chiappori A et al (2008) Cardiac toxicity: old and new issues in anti-cancer drugs. Clin Transl Oncol 10(1):35–46
Shapiro CL, Hardenbergh PH, Gelman R et al (1998) Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients. J Clin Oncol 16(11):3493–3501
Shigeno K, Naito K, Sahara N et al (2005) Arsenic trioxide therapy in relapsed or refractory Japanese patients with acute promyelocytic leukemia: updated outcomes of the phase II study and postremission therapies. Int J Hematol 82(3):224–229
Shimizu Y, Pierce DA, Preston DL et al (1999) Studies of the mortality of atomic bomb survivors. Report 12, part II. noncancer mortality: 1950–1990. Radiat Res 152(4):374–389
Shiojima I, Sato K, Izumiya Y et al (2005) Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 115(8):2108–2118
Shoemaker LK, Arora U (2004) Rocha Lima CM. 5-fluorouracil-induced coronary vasospasm. Cancer Control 11(1):46–49
Singal PK, Iliskovic N (1998) Doxorubicin-induced cardiomyopathy. N Engl J Med 339(13):900–905
Singer JW (2001) Cardiac toxicity of arsenic trioxide. Blood 98(5):1633–1634
Slamon DJ, Leyland-Jones B, Shak S et al (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344(11):783–792
Soignet SL, Frankel SR, Douer D et al (2001) United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol 19(18):3852–3860
Sorensen K, Levitt G, Sebag-Montefiore D et al (1995) Cardiac function in Wilms’ tumor survivors. J Clin Oncol 13(7):1546–1556
Spector NL, Yarden Y, Smith B et al (2007) Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A 104(25):10607–10612
Stewart JR, Fajardo LF, Gillette SM et al (1995) Radiation injury to the heart. Int J Radiat Oncol Biol Phys 31(5):1205–1211
Stewart FA, Heeneman S, Te PJ et al (2006) Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol 168(2):649–658
Stewart FA, Hoving S, Russell NS (2010) Vascular damage as an underlying mechanism of cardiac and cerebral toxicity in irradiated cancer patients. Radiat Res 174(6):865–869
Stickeler E, Klar M, Watermann D et al (2009) Pegylated liposomal doxorubicin and trastuzumab as 1st and 2nd line therapy in her2/neu positive metastatic breast cancer: a multicenter phase II trial. Breast Cancer Res Treat 117(3):591–598
Strasser F, Betticher DC, Suter TM (2001) Trastuzumab and breast cancer. N Engl J Med 345(13):996
Subgroup on Circulatory Disease Risk of the Advisory Group on Ionising Radiation (2010) Circulatory Disease Risk RCE 16, Chilton, pp 1–130 (in press) Ref Type: Report http://www.icrp.org/page.asp?id=116
Sudhoff T, Enderle MD, Pahlke M et al (2004) 5-Fluorouracil induces arterial vasocontractions. Ann Oncol 15(4):661–664
Suter TM, Procter M, van Veldhuisen DJ et al (2007) Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol 25(25):3859–3865
Swain SM, Whaley FS, Gerber MC et al (1997) Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol 15(4):1318–1332
Swerdlow AJ, Higgins CD, Smith P et al (2007) Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 99(3):206–214
Talreja DR, Edwards WD, Danielson GK et al (2003) Constrictive pericarditis in 26 patients with histologically normal pericardial thickness. Circulation 108(15):1852–1857
Tan-Chiu E, Yothers G, Romond E et al (2005) Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 23(31):7811–7819
Taylor CW, McGale P, Darby SC (2006) Cardiac risks of breast-cancer radiotherapy: a contemporary view. Clin Oncol (R Coll Radiol) 18(3):236–246
Tillman B (2007) Atlas of Human Anatomy, Mud Puddle Books Inc, New York, pp 224
Tirilomis T, Unverdorben S, von der Emde J (1994) Pericardectomy for chronic constrictive pericarditis: risks and outcome. Eur J Cardiothorac Surg 8(9):487–492
Tribble DL, Barcellos-Hoff MH, Chu BM et al (1999) Ionizing radiation accelerates aortic lesion formation in fat-fed mice via SOD-inhibitable processes. Arterioscler Thromb Vasc Biol 19(6):1387–1392
Tripathy D, Slamon DJ, Cobleigh M et al (2004) Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 22(6):1063–1070
Trudeau ME, Clemons MJ, Provencher L et al (2009) Phase II multicenter trial of anthracycline rechallenge with pegylated liposomal doxorubicin plus cyclophosphamide for first-line therapy of metastatic breast cancer previously treated with adjuvant anthracyclines. J Clin Oncol 27(35):5906–5910
Tsavaris N, Kosmas C, Vadiaka M et al (2002) Cardiotoxicity following different doses and schedules of 5-fluorouracil administration for malignancy—a survey of 427 patients. Med Sci Monit 8(6):I51–I57
Tsibiribi P, Descotes J, Lombard-Bohas C et al (2006a) Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease. Bull Cancer 93(3):E27–E30
Tsibiribi P, Bui-Xuan C, Bui-Xuan B et al (2006b) Cardiac lesions induced by 5-fluorouracil in the rabbit. Hum Exp Toxicol 25(6):305–309
Tukenova M, Guibout C, Oberlin O et al (2010) Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol 28(8):1308–1315
Unnikrishnan D, Dutcher JP, Garl S et al (2004) Cardiac monitoring of patients receiving arsenic trioxide therapy. Br J Haematol 124(5):610–617
Van Cutsem E, Hoff PM, Blum JL et al (2002) Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil. Ann Oncol 13(3):484–485
Van Dalen EC, Caron HN, Dickinson HO et al (2008) Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev 2:CD003917
Van Dalen EC, van der Pal HJ, Caron HN et al (2009) Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy. Cochrane Database Syst Rev 4:CD005008
Van Heeckeren WJ, Sanborn SL, Narayan A et al (2007) Complications from vascular disrupting agents and angiogenesis inhibitors: aberrant control of hemostasis and thrombosis. Curr Opin Hematol 14(5):468–480
Van Kuilenburg AB, Meinsma R, Zoetekouw L et al (2002) Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14 + 1 g > a mutation. Int J Cancer 101(3):253–258
Van Luijk P, Faber H, Meertens H et al (2007) The impact of heart irradiation on dose-volume effects in the rat lung. Int J Radiat Oncol Biol Phys 69(2):552–559
Veinot JP, Edwards WD (1996) Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases. Hum Pathol 27(8):766–773
Verheij M, Dewit LG, Valdes Olmos RA et al (1994) Evidence for a renovascular component in hypertensive patients with late radiation nephropathy. Int J Radiat Oncol Biol Phys 30(3):677–683
Vermorken JB, Remenar E, van Herpen C et al (2007) Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 357(17):1695–1704
Vogel CL, Cobleigh MA, Tripathy D et al (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20(3):719–726
Von Hoff DD, Layard MW, Basa P et al (1979) Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 91(5):710–717
Voortman J, Giaccone G (2006) Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report. BMC Cancer 6:129
Vorchheimer DA (2005) What is QT interval prolongation? J Fam Pract Suppl:S4–S7
Vos J, Aarnoudse MW, Dijk F et al (1983) On the cellular origin and development of atheromatous plaques. A light and electron microscopic study of combined X-ray and hypercholesterolemia-induced atheromatosis in the carotid artery of the rabbit. Virchows Arch B Cell Pathol Incl Mol Pathol 43(1):1–16
Wacker A, Lersch C, Scherpinski U et al (2003) High incidence of angina pectoris in patients treated with 5-fluorouracil. A planned surveillance study with 102 patients. Oncology 65(2):108–112
Walko CM, Lindley C (2005) Capecitabine: a review. Clin Ther 27(1):23–44
Wei X, Liu HH, Tucker SL et al (2008) Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys 70(3):707–714
Westervelt P, Brown RA, Adkins DR et al (2001) Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide. Blood 98(2):266–271
Wethal T, Kjekshus J, Roislien J et al (2007) Treatment-related differences in cardiovascular risk factors in long-term survivors of testicular cancer. J Cancer Surviv 1(1):8–16
Wethal T, Lund MB, Edvardsen T et al (2009) Valvular dysfunction and left ventricular changes in Hodgkin’s lymphoma survivors. A longitudinal study. Br J Cancer 101(4):575–581
Wojnowski L, Kulle B, Schirmer M et al (2005) NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation 112(24):3754–3762
Wong FL, Yamada M, Sasaki H et al (1993) Noncancer disease incidence in the atomic bomb survivors: 1958–1986. Radiat Res 135(3):418–430
Wouters KA, Kremer LC, Miller TL et al (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131(5):561–578
Wu S, Chen JJ, Kudelka A et al (2008) Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysis. Lancet Oncol 9(2):117–123
Yamaguchi O, Watanabe T, Nishida K et al (2004) Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 114(7):937–943
Yang JC, Haworth L, Sherry RM et al (2003) A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349(5):427–434
Yeh ET, Bickford CL (2009) Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 53(24):2231–2247
Yeh ET, Tong AT, Lenihan DJ et al (2004) Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation 109(25):3122–3131
Yusuf S, Hawken S, Ounpuu S et al (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364(9438):937–952
Zangari M, Elice F, Fink L et al (2007) Thrombosis in multiple myeloma. Expert Rev Anticancer Ther 7(3):307–315
Zhao YY, Sawyer DR, Baliga RR et al (1998) Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 273(17):10261–10269
Zuppinger C, Timolati F, Suter TM (2007) Pathophysiology and diagnosis of cancer drug induced cardiomyopathy. Cardiovasc Toxicol 7(2):61–66
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Chen MH, Colan SD, and Diller LD (2011) Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res 108:619–628
Adams MJ, Lipshultz SE (2005) Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: Implications for screening and prevention. Pediatr Blood Cancer 44(7):600–606
Schultz-Hector S, Trott KR (2007) Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys 67(1):10–18
Gagliardi G, Constine LS, Moiseenko V, Correa C, Pierce LJ, Allen AM et al (2010) Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys 76(3 Suppl):S77–S85
Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K et al (2010) Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys 76(3):656–665
De Haas EC, Oosting SF, Lefrandt JD, Wolffenbuttel BH, Sleijfer DT, Gietema JA (2010) The metabolic syndrome in cancer survivors. Lancet Oncol 11(2):193–203
Albini A, Pennesi G, Donatelli F, Cammarota R, De FS, Noonan DM (2010) Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention. J Natl Cancer Inst 102(1):14–25
ACC/AHA guidelines on treatment of heart failure
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Aleman, B.M.P., Specht, L., Chen, M.H. (2014). Heart, Coronary Arteries, Aorta and Great Vessels, Arteries and Veins, Microcirculation. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_12
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