Due to the difficulty of obtaining tissue samples from victims of the ancient plagues, it is not always possible to utilise palaeomicrobiology techniques to determine the etiology of ancient infection. Therefore, it is often necessary to utilise other means to arrive at a likely diagnosis. The most helpful of these is the literary description of the disease. While this is often the best evidence available, working with such documents can prove difficult. Three great plagues of the ancient world, the Plague of Athens, the Antonine Plague, and the Justiniac Plague are described in either Latin or ancient Greek. The difficulties encountered when translating any ancient foreign language are compounded by the fact that so many words in these languages have a variety of meanings. This chapter reviews the three great plagues of antiquity from a clinical perspective.
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References
Antia R, Regoes RR, Koella JC, Bergstrom CT (2003) The role of evolution in the emergence of infectious diseases. Nature 426:658–661
Arriaza BT, Salo W, Aufderheide AC, Holcomb TA (1995) Pre-Columbian tuberculosis in northern Chile: molecular and skeletal evidence. Am J Phys Anthropol 98:37–45
Aufderheide AC, Rodriguez-Martin C (1998) Smallpox. In: The Cambridge encyclopedia of human palaeopathology. Cambridge University Press, Cambridge, pp 201–207
Bollet AJ (1987) Plagues and poxes. Demos, New York
Bratton TL (1981a) The identity of the Plague of Justinian. Trans Stud Coll Physicians Philadelphia 3:113–124
Bratton TL (1981b) The identity of the Plague of Justinian (Part II). Trans Stud Coll Physicians Philadelphia 3:174–180
Brothwell J, Sandison AT (1967) Diseases in antiquity. Thomas, Springfield, IL
Cartwright FF (1972) Disease and history: the black death. Dorset, New York
Christie AB (1969) Infectious diseases: epidemiology and clinical practice. Churchill-Livingstone, Edinburgh
Cockburn TA (1971) Infectious disease in ancient populations. Curr Anthropol 12:45–62
Cooper A, Poinar HN (2000) Ancient DNA: do it right or not at all. Science 289:1139
Cunha BA (2002) Smallpox: an Oslerian primer. Infect Dis Pract 26:141–148
Cunha BA (2004a) Smallpox and measles: historical aspects and clinical differentiation. Infect Dis Clin N Am 18:79–100
Cunha BA (2004b) The cause of the plague of Athens: plague, typhus, smallpox, or measles? Infect Dis Clin N Am 18:29–43
Cunha CB, Cunha BA (2006) Impact of plague on human history. Infect Dis Clin Am 20:253–272
Drancourt M, Raoult D (2002) Molecular insights into the history of plague. Microbes Infect 4:105–109
Drancourt M, Raoult D (2004) Molecular detection of Yersinia pestis in dental pulp. Microbiology 150:263–264
Drancourt M, Raoult D (2005) Paleomicrobiology: current issues and perspectives. Nature Rev Microbiol 3:23–35
Drancourt M, Aboudharam G, Signoli M, Dutour O, Raoult D (1998) Detection of 400-year-old Yersinia pestis DNA in human dental pulp: an approach to the diagnosis of ancient septicemia. Proc Natl Acad Sci USA 95:12637–12640
Drancourt M, Roux V, Dang LV, Tran-Hung L, Castex D, Chenal-Francisque V, Ogata H, Fournier P-E, Crubézy E, Raoult D (2004) Genotyping, Orientalis-like Yersinia pestis, and plague pandemic. Emerg Infect Dis 10:1585–1592
Fears JR (2004) The Plague under Marcus Aurelius and the decline and fall of the Roman Empire. Infect Dis Clin N Am 20:65–77
Fenner F, Henderson DA, Arita I (1988) Smallpox and its eradication. World Health Organization, Geneva
Gilbert MT, Willerslev E, Hansen AJ, Barnes I, Rudbeck L, Lynnerup N, Cooper A (2003) Distribution patterns of postmortem damage in human mitochondrial DNA. Am J Hum Genet 72:32–47
Gilliam JF (1961) The Plague under Marcus Aurelius. Am J Philol 30:225–251
Hofreiter M, Serre D, Poinar HN, Kuch M, Paabo S (2001) Ancient DNA. Nature Rev Genet 2:353–359
Hopkins DR (2002) The greatest killer: smallpox in history. University of Chicago Press, Chicago, pp 13–317
Jackson PJ, Hugh-Jones ME, Adair DM, Green G, Hill KK, Kuske CR, Grinberg LM, AbramovaFA, Keimi P (1998) PCR analysis of tissue samples from the 1979 Sverdovsk anthrax victims: the presence of multiple Bacillus anthracis strains in different victims. Proc Natl Acad Sci USA 95:1224–1229
Kiple KF (1993) The Cambridge world history of human diseases. Cambridge University Press, New York
Li HC, Fujiyoshi T, Lou H, Yashiki S, Sonoda S, Cartier L, Nunez L, Munoz I, Horai S, Tajima K (1999) The presence of ancient human T-cell lymphotropic virus type 1 provirus DNA in an Andean mummy. Nature Med 5:1428–1432
Littman RJ, Littman ML (1973) Galen and the Antonine plague. Am J Philol 94:243–255
Longrigg J (1980) The great plague of Athens. Hist Sci 18:209–225
Major RH (1978) Smallpox and measles. In: Classic descriptions of disease. Thomas, Springfield, IL, pp 196–200
Martin PMV, Martin-Granel E (2006) 2, 500-year evolution of the term epidemic. Emerg Infect Dis 12:976–980
McNeill WH (1976) Plagues and peoples: a natural history of infectious diseases. Anchor, New York
Meers PD (1985) Smallpox still entombed? Lancet 1:1103
Oldstone MBA (1998) Smallpox. In: Viruses, plagues, and history. Oxford University Press, Oxford pp 27–44
Osler W (1876a) The initial rashes of smallpox. Can Med Surg J 5:241–255
Osler W (1876b) Haemorrhagic smallpox. Can Med Surg J 5:289–304
Osler W (1892) The principles and practice of medicine. Appleton, New York, pp 46–59
Pääbo S (1989) Ancient DNA extraction, characterization, molecular cloning, and enzymatic amplification. Proc Natl Acad Sci USA 86:1939–1943
Page DL (1953) Thucydides description of the plague. Class Q 3:97–119
Parry A (1969) The language of Thucydides’ description of the plague. Bull Inst Class Stud 16:106–118
Procopius (1981) Histories of the wars. Dewing HB (translator), Loeb Classical Library, Harvard University Press, Cambridge
Raoult D, Aboudharam G, Crubézy E, Larrouy G, Ludes B, Drancourt M (2000) Molecular identification by “suicide PCR” of Yersinia pestis as the agent of medieval black death. Proc Natl Acad Sci USA 97:12800–12803
Reid AH, Fanning TG, Janczewski TA, Taubenberger JK (2000) Characterization of the 1918 “Spanish” influenza virus neuraminidase gene. Proc Natl Acad Sci USA 97:6785–6790
Ricketts TF (1908) The diagnosis of smallpox. Cassell, London
Roberts C, Manchester K (2005) The archaeology of disease, 3rd edn. Cornell University Press, Ithaca, NY
Rollo F, Luciani S, Canapa A, Marota I (2000) Analysis of bacterial DNA in skin and muscle of the Tyrolean iceman offers new insight into the mummification process. Am J Phys Anthropol 111:211–219
Shrewsbury JFD (1950) The plague of Athens. Bull Hist Med 24:1–25
Soupios MA (2004) Impact of the plague in Ancient Greece. Infect Dis Clin N Am 18:45–51
Spencer M, Howe CJ (2004) Authenticity of ancient DNA results: a statistical approach. Am J Hum Genet 75:240–250
Taubenberger JK, Reid AH, Krafft AE, Bjwaard KE, Fanning TG (1997) Initial genetic characterization of the 1918 “Spanish” influenza virus. Science 275:1793–1796
Thucydides (1919) History of the Peloponnesian War, books I and II. Harvard University Press, London, pp 341–359
Thucydides (1989) The Peloponnesian War. Cambridge University Press, New York
Tumpey TM, García-Sastre A, Taubenberger JK, Palese P, Swayne DE, Basler CF (2004) Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proc Natl Acad Sci USA 101:3166–3171
Zink AR, Reischi U, Wolt H, Nerlich AG (2002) Molecular analysis of ancient microbial infections. FEMS Microbiol Lett 213:141–147
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Cunha, C.B., Cunha, B.A. (2008). Great Plagues of the Past and Remaining Questions. In: Raoult, D., Drancourt, M. (eds) Paleomicrobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75855-6_1
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