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Metastasis

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Intraocular Inflammation

Abstract

Metastasis refers to the spread of malignant cells to a site or sites distant from a primary cancer’s location. In the setting of uveitis, metastatic lesions may produce a true uveitis that is an inflammatory response to malignancy within the eye. Metastatic disease may also result in an appearance mimicking a uveitis, wherein the cellular reaction is composed of malignant rather than inflammatory cells. Lung and breast cancer are by far the most common, respectively representing 37 and 23 % of all cases, but numerous other primary sources of malignancy have also been reported, including esophageal, pancreatic, germ cell, ovarian, Ewing’s sarcoma, and melanoma. Finally, treatments for metastatic disease may produce a drug-induced uveitis.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Alabama at Birmingham, 700 18th Street South, Suite 601, Birmingham, AL, 35233, USA

    Russell W. Read MD, PhD

Authors
  1. Russell W. Read MD, PhD
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Corresponding author

Correspondence to Russell W. Read MD, PhD .

Editor information

Editors and Affiliations

  1. Centre of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut

  2. Biomedical Research Centre, Institute of Ophthalmology, Moorfields Eyes Hospital, Department of Medical Retina, UCL, London, United Kingdom

    Carlos Pavesio

  3. School of Medicine, Department of Ophthalmology, Hokkaido University Graduate, Sapporo, Hokkaido, Japan

    Shigeaki Ohno

  4. University of Belo Horizonte, Belo Horizonte, Brazil

    Fernando Orefice

  5. USC Eye Institute, University of Southern California, Los Angeles, California, USA

    Narsing A. Rao

1 Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Case Report 97

Choroidal metastasis masquerading as uveitis (PPTX 10905 kb)

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© 2016 Springer-Verlag Berlin Heidelberg

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Read, R.W. (2016). Metastasis. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_150

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  • DOI: https://doi.org/10.1007/978-3-540-75387-2_150

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-75385-8

  • Online ISBN: 978-3-540-75387-2

  • eBook Packages: MedicineMedicine (R0)

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