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Primary Intraocular Lymphoma

  • Chapter
Intraocular Inflammation

Abstract

Primary intraocular lymphoma (PIOL) is a neoplasm, most frequently of B-cell and rarely T-cell origin arising from or initially presenting in the eye. PIOL of the B-cell type is a non-Hodgkin’s lymphoma of the diffuse large B-cell type that belongs within the category of primary central nervous system lymphoma (PCNSL). The lymphoma always is located in the subretinal space, retina, vitreous, and/or optic nerve. Since the retina, retinal pigment epithelium (RPE), and optic nerve are derived from the same neuroectoderm as the CNS during embryogenesis, and both the eye and CNS are immune-privileged organs, PIOL is often considered to be a subtype of PCNSL. Although a subtype of PCNSL, PIOL may arise de novo in the neuroretina rather than secondary involvement from a PCNSL.

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Author information

Authors and Affiliations

  1. Section of Immunopathology, Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA

    Chi-Chao Chan MD

  2. Department of Internal Medicine, University of Tuebingen, Tuebingen, Germany

    Sebastian P. Haen & Robert Möhle

  3. Center of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut MD

Authors
  1. Chi-Chao Chan MD
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  2. Sebastian P. Haen
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  3. Robert Möhle
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  4. Manfred Zierhut MD
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Corresponding author

Correspondence to Manfred Zierhut MD .

Editor information

Editors and Affiliations

  1. Centre of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut

  2. Biomedical Research Centre, Institute of Ophthalmology, Moorfields Eyes Hospital, Department of Medical Retina, UCL, London, United Kingdom

    Carlos Pavesio

  3. School of Medicine, Department of Ophthalmology, Hokkaido University Graduate, Sapporo, Hokkaido, Japan

    Shigeaki Ohno

  4. University of Belo Horizonte, Belo Horizonte, Brazil

    Fernando Orefice

  5. USC Eye Institute, University of Southern California, Los Angeles, California, USA

    Narsing A. Rao

1 Electronic Supplementary Material

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Case Report 12

Intraocular lymphoma (PPT 3141 kb)

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Chan, CC., Haen, S.P., Möhle, R., Zierhut, M. (2016). Primary Intraocular Lymphoma. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_147

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