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Varicella-Zoster Virus

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Intraocular Inflammation

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Abstract

Varicella-zoster virus (VZV) or human herpesvirus type 3 can cause two different clinical pictures: varicella (or chickenpox), the primary infection, affecting mainly children and young adults, characterized by an acute exanthema involving all the skin in the context of fever and malaise, and herpes zoster (HZ or shingles), the result of reactivation of the latent VZV within the sensory ganglia. Although primary varicella may be mild or unrecognized, more than 90 % of the adult population is seropositive for VZV, stressing the wide distribution of this virus. Primary contact may also occur with the strain used for vaccination (Oka strain), and there are reported cases of HZ even years after prophylactic immunization. The host’s T cell-mediated immunity to VZV is the major determinant of the risk and severity of HZ.

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References

  1. Esmaeli-Gutstein B, Winkelman JZ (1999) Uveitis associated with varicella virus vaccine. Am J Ophthalmol 127:733–734

    Article  CAS  PubMed  Google Scholar 

  2. Naseri A, Good WV, Cunningham ET Jr (2003) Herpes zoster virus sclerokeratitis and anterior uveitis in a child following varicella vaccination. Am J Ophthalmol 135(3):415–417

    Article  PubMed  Google Scholar 

  3. Hope-Simpson RE, (please add add. authors) (1965) The nature of herpes zoster: a long-term study and a new hypothesis. Proc R Soc Med 58:9–20

    Google Scholar 

  4. Marsh RJ, Cooper M (1993) Ophthalmic herpes zoster. Eye (Lond) 7(Pt 3):350–370

    Article  Google Scholar 

  5. Wensing B, de Groot-Mijnes JD, Rothova A (2011) Necrotizing and nonnecrotizing variants of herpetic uveitis with posterior segment involvement. Arch Ophthalmol 129(4):403–408

    Article  PubMed  Google Scholar 

  6. Guex-Crosier Y, Rochat C, Herbort CP (1997) Necrotizing herpetic retinopathies. A spectrum of herpes virus-induced diseases determined by the immune state of the host. Ocul Immunol Inflamm 5(4):259–265

    Article  CAS  PubMed  Google Scholar 

  7. Jabs DA et al (1987) Presumed varicella zoster retinitis in immunocompromised patients. Retina 7(1):9–13

    CAS  PubMed  Google Scholar 

  8. Forster DJ et al (1990) Rapidly progressive outer retinal necrosis in the acquired immunodeficiency syndrome. Am J Ophthalmol 110(4):341–348

    Article  CAS  PubMed  Google Scholar 

  9. Margolis TP et al (1991) Varicella-zoster virus retinitis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol 112(2):119–131

    Article  CAS  PubMed  Google Scholar 

  10. Kashiwase M et al (2000) Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome. Ophthalmology 107(4):790–794

    Article  CAS  PubMed  Google Scholar 

  11. You YS et al (2007) Progressive outer retinal necrosis combined with vitreous hemorrhage in a patient with acquired immunodeficiency syndrome. Korean J Ophthalmol 21(1):51–54

    Article  PubMed Central  PubMed  Google Scholar 

  12. Zaal MJ, Volker-Dieben HJ, D’Amaro J (2003) Prognostic value of Hutchinson’s sign in acute herpes zoster ophthalmicus. Graefes Arch Clin Exp Ophthalmol 241(3):187–191

    Article  PubMed  Google Scholar 

  13. Miserocchi E et al (2002) Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparison. Ophthalmology 109(8):1532–1537

    Article  PubMed  Google Scholar 

  14. Maudgal PC et al (1980) Varicella-zoster virus in the human corneal endothelium: a case report. Bull Soc Belge Ophtalmol 190:71–86

    CAS  PubMed  Google Scholar 

  15. Engstrom RE Jr et al (1994) The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS. Ophthalmology 101(9):1488–1502

    Article  PubMed  Google Scholar 

  16. Margolis TP et al (1998) Herpes zoster ophthalmicus in patients with human immunodeficiency virus infection. Am J Ophthalmol 125(3):285–291

    Article  CAS  PubMed  Google Scholar 

  17. van den Horn GJ, Meenken C, Troost D (1996) Association of progressive outer retinal necrosis and varicella zoster encephalitis in a patient with AIDS. Br J Ophthalmol 80(11):982–985

    Article  PubMed Central  PubMed  Google Scholar 

  18. Bodaghi B, Rozenberg F, Cassoux N, Fardeau C, LeHoang P (2003) Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis. Ophthalmology 110(9):1737–1743

    Article  PubMed  Google Scholar 

  19. Liesegang TJ (2008) Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity. Ophthalmology 115(2 Suppl):S3–S12

    Article  PubMed  Google Scholar 

  20. Lewis JM, Nagae Y, Tano Y (1996) Progressive outer retinal necrosis after bone marrow transplantation. Am J Ophthalmol 122(6):892–895

    Article  CAS  PubMed  Google Scholar 

  21. Njoo FL, Rothova A, Van Der Lelij A (1998) Progressive outer retinal necrosis in a patient with cutaneous non-Hodgkin’s T cell lymphoma (Sezary syndrome). Br J Ophthalmol 82(10):1218–1219

    CAS  PubMed  Google Scholar 

  22. Carrillo-Pacheco S et al (1996) Progressive outer retinal necrosis in an immunocompetent patient. Acta Ophthalmol Scand 74(5):506–508

    Article  CAS  PubMed  Google Scholar 

  23. Benz MS, Glaser JS, Davis JL (2003) Progressive outer retinal necrosis in immunocompetent patients treated initially for optic neuropathy with systemic corticosteroids. Am J Ophthalmol 135(4):551–553

    Article  CAS  PubMed  Google Scholar 

  24. Nakamura M et al (2000) Zoster sine herpete with bilateral ocular involvement. Am J Ophthalmol 129(6):809–810

    Article  CAS  PubMed  Google Scholar 

  25. Schwab IR (1997) Herpes zoster sine herpete. A potential cause of iridoplegic granulomatous iridocyclitis. Ophthalmology 104(9):1421–1425

    Article  CAS  PubMed  Google Scholar 

  26. Van der Lelij A et al (2000) Anterior uveitis with sectoral iris atrophy in the absence of keratitis: a distinct clinical entity among herpetic eye diseases. Ophthalmology 107(6):1164–1170

    Article  PubMed  Google Scholar 

  27. Barequet IS, Li Q, Wang Y, O’Brien TP, Hooks JJ, Stark WJ (2000) Herpes simplex virus DNA identification from aqueous fluid in fuchs heterochromic iridocyclitis. Am J Ophthalmol 129(5):672–673

    Article  CAS  PubMed  Google Scholar 

  28. Chee SP, Jap A (2008) Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. Am J Ophthalmol 146(6):883–889

    Article  PubMed  Google Scholar 

  29. Yamamoto S, Pavan-Langston D, Tada R, Yamamoto R, Kinoshita S, Nishida K, Shimomura Y, Tano Y (1995) Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome. Am J Ophthalmol 119(6):796–798

    Article  CAS  PubMed  Google Scholar 

  30. Moshfeghi DM et al (2004) Diagnostic approaches to severe, atypical toxoplasmosis mimicking acute retinal necrosis. Ophthalmology 111(4):716–725

    Article  PubMed  Google Scholar 

  31. Moorthy RS et al (1997) Management of varicella zoster virus retinitis in AIDS. Br J Ophthalmol 81(3):189–194

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Pavesio CE et al (1995) Progressive outer retinal necrosis (PORN) in AIDS patients: a different appearance of varicella-zoster retinitis. Eye (Lond) 9(Pt 3):271–276

    Article  Google Scholar 

  33. Nagasako EM et al (2002) Rash severity in herpes zoster: correlates and relationship to postherpetic neuralgia. J Am Acad Dermatol 46(6):834–839

    Article  PubMed  Google Scholar 

  34. Tran TH, Bodaghi B, Rozenberg F, Cassoux N, Fardeau C, LeHoang P (2004) Viral cause and management of necrotizing herpetic retinopathies. J Fr Ophtalmol 27(3):223–236

    Article  CAS  PubMed  Google Scholar 

  35. Gore DM, Gore SK, Visser L (2012) Progressive outer retinal necrosis: outcomes in the intravitreal era. Arch Ophthalmol 130(6):700–706

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Austral University School of Medicine, Buenos Aires, Argentine

    Karina Julian MD

  2. Uveitis Department, Instituto de la Visión, M.T. de Alvear 2261, 1122, Ciudad de Buenos Aires, Argentine

    Karina Julian MD

  3. Ophthalmology Department, Pitié-Salpêtrière Hospital, 47 Boulevard de l’Hôpital, 75013, Paris, France

    Bahram Bodaghi MD, PhD

Authors
  1. Karina Julian MD
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  2. Bahram Bodaghi MD, PhD
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Corresponding author

Correspondence to Karina Julian MD .

Editor information

Editors and Affiliations

  1. Centre of Ophthalmology, University of Tuebingen, Tuebingen, Germany

    Manfred Zierhut

  2. Biomedical Research Centre, Institute of Ophthalmology, Moorfields Eyes Hospital, Department of Medical Retina, UCL, London, United Kingdom

    Carlos Pavesio

  3. School of Medicine, Department of Ophthalmology, Hokkaido University Graduate, Sapporo, Hokkaido, Japan

    Shigeaki Ohno

  4. University of Belo Horizonte, Belo Horizonte, Brazil

    Fernando Orefice

  5. USC Eye Institute, University of Southern California, Los Angeles, California, USA

    Narsing A. Rao

1 Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Case Report 41

Acute retinal necrosis (PPT 4582 kb)

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© 2016 Springer-Verlag Berlin Heidelberg

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Julian, K., Bodaghi, B. (2016). Varicella-Zoster Virus. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_117

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  • DOI: https://doi.org/10.1007/978-3-540-75387-2_117

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-75385-8

  • Online ISBN: 978-3-540-75387-2

  • eBook Packages: MedicineMedicine (R0)

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