Abstract
The dissection of genetic resistance to murine cytomegalovirus infection in inbred laboratory mouse strains led to the identification of a natural killer cell activation receptor that recognizes a virus-encoded protein. Herein, we summarize the genetic approach and findings that have provided novel insights into innate immune control of virus infections.
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Abbreviations
- CMV:
-
Cytomegalovirus
- DAP12:
-
DNAX activating protein of 12 kDa
- Δm157:
-
MCMV clone lacking m157 expression
- ENU:
-
N-Ethyl-N-nitrosourea
- GFP:
-
Green fluorescent protein
- HCMV:
-
Human CMV
- Ig:
-
Immunoglobulin
- ILT:
-
Ig-like transcripts
- ITAM:
-
Immunoreceptor tyrosine-based activation motif
- ITIM:
-
Immunoreceptor tyrosine-based inhibitory motif
- KARAP:
-
Killer associated receptor adapter protein
- KIR:
-
Killer Ig-like receptor
- LCMV:
-
Lymphocytic choriomeningitis virus
- MCMV:
-
Murine CMV
- mAb:
-
Monoclonal antibody
- MHC:
-
Major histocompatibility complex
- NK:
-
Natural killer
- NKC:
-
NK gene complex
- ORF:
-
Open reading frame
- RI:
-
Recombinant inbred
- SCID-MCMV:
-
MCMV clones isolated from scid mice
- TLR:
-
Toll-like receptor
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Scalzo, A.A., Yokoyama, W.M. (2008). Cmv1 and Natural Killer Cell Responses to Murine Cytomegalovirus Infection. In: Beutler, B. (eds) Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology. Current Topics in Microbiology and Immunology, vol 321. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75203-5_5
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