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Structure-Function Relationships Among RNA-Dependent RNA Polymerases

  • Chapter
RNA Interference

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 320))

Abstract

RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the basic structural and mechanistic principles gleaned from studies of viral RdRPs. Therefore, studies of the viral RdRP establish a framework for the study of cellular RdRPs, an important yet understudied class of nucleic acid polymerases.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada

    Kenneth K.-S. Ng

  2. Department of Biochemistry and Molecular Biology The Pennsylvania State University, 201 Althouse Laboratory, University Park, PA, 16802, USA

    Craig E. Cameron

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  1. Kenneth K.-S. Ng
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  2. Jamie J. Arnold
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  3. Craig E. Cameron
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Editors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor Fellows Program, Cold Spring Harbor, NY, 11771

    Patrick J. Paddison

  2. Department of Molecular & Experimental Medicine Division of Oncovirology, The Scripps Research Institute, 10550 N. Torrey Pines Road, BCC-239, La Jolla, CA, 92037, USA

    Peter K. Vogt

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Ng, KS., Arnold, J.J., Cameron, C.E. (2008). Structure-Function Relationships Among RNA-Dependent RNA Polymerases. In: Paddison, P.J., Vogt, P.K. (eds) RNA Interference. Current Topics in Microbiology and Immunology, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75157-1_7

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